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为了作业，在精读一篇Bioorganic&Medicinal Chemistry Letters上的英文文献，对其中一点关于实验结果的内容理解有问题，觉得文字叙述内容与表格所给的结果不一致，盼各位指点...... 内容如下： Modification of the amino substituent gave the isomeric tetramethyl derivative 17 and the 4,7-dihydroindanyl indacaterol derivative 29 which had comparable decreases in affinity and selectivity when compared to 1. The 5-n-butylindanyl analogue 16, as a diasteroisomeric mixture epimeric at the 2-indanyl position, exhibited a similar binding profile to 1, suggesting the potential for a similar overall profile. However, the additional stereochemical complexity in 16 reduced the attractiveness of this analogue for further follow up studies. Introduction of the a-methyl group into the amino substituent gave the analogue 25 which led to the anticipated increase in b2adrenoceptor affinity, of greater than 10-fold relative to 1.However, this increase in affinity was also accompanied by an even greater relative increase in b1-adrenoceptor affinity and an overall reduction in binding selectivity. 表如下：（附件里，弄不上来） 希望各位不吝各抒己见，指导指导我这个马上要交作业的人......  HW5~KR45$B1]T(5S6J@{`X4.jpg |
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7楼2012-10-24 16:27:10
2楼2012-10-23 19:43:46
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是因为看到一大段的英文而没人回么？ 请就看这3句： 化合物17、29的 Modification of the amino substituent gave the isomeric tetramethyl derivative 17 and the 4,7-dihydroindanyl indacaterol derivative 29 which had comparable decreases in affinity and selectivity when compared to 1. 化合物16的 Introduction of the a-methyl group into the amino substituent gave the analogue 25 which led to the anticipated increase in b2adrenoceptor affinity, of greater than 10-fold relative to 1.However, this increase in affinity was also accompanied by an even greater relative increase in b1-adrenoceptor affinity and an overall reduction in binding selectivity. 谢谢！！！ |
3楼2012-10-24 08:44:25
6楼2012-10-24 16:26:33
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