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[交流] 文献理解

为了作业，在精读一篇Bioorganic&Medicinal Chemistry Letters上的英文文献，对其中一点关于实验结果的内容理解有问题，觉得文字叙述内容与表格所给的结果不一致，盼各位指点......
内容如下：
Modification of the amino substituent gave the isomeric tetramethyl derivative 17 and the 4,7-dihydroindanyl indacaterol derivative 29 which had comparable decreases in affinity and selectivity when compared to 1. The 5-n-butylindanyl analogue 16, as a diasteroisomeric mixture epimeric at the 2-indanyl position, exhibited a similar binding profile to 1, suggesting the potential for a similar overall profile. However, the additional stereochemical complexity in 16 reduced the attractiveness of this analogue for further follow up studies. Introduction of the a-methyl group into the amino substituent gave the analogue 25 which led to the anticipated increase in b2adrenoceptor affinity, of greater than 10-fold relative to 1.However, this increase in affinity was also accompanied by an even greater relative increase in b1-adrenoceptor affinity and an overall reduction in binding selectivity.
表如下：（附件里，弄不上来）
希望各位不吝各抒己见，指导指导我这个马上要交作业的人......

HW5~KR45$B1]T(5S6J@{`X4.jpg

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1楼 2012-10-23 19:36:22

已阅关注TA 给TA发消息送TA红花 TA的回帖

何超

金虫 (正式写手)

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我的理解，化合物17、29，文字叙述说对b2肾上腺素受体的亲和力和选择都下降，而表的内容显示应该是都升高的
还有关于化合物25的叙述说对b2肾上腺素受体的亲和力增加，表里内容是降低的
你们可能会说，是我对那个K的意义理解错了，我觉得应该是结合的速率与分解的速率之比，而且根据这一理解能与前面关于其他化合物的叙述相符
不知道是怎么回事，盼指教......

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2楼2012-10-23 19:43:46

已阅关注TA 给TA发消息送TA红花 TA的回帖

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是因为看到一大段的英文而没人回么？
请就看这3句：
化合物17、29的 Modification of the amino substituent gave the isomeric tetramethyl derivative 17 and the 4,7-dihydroindanyl indacaterol derivative 29 which had comparable decreases in affinity and selectivity when compared to 1.
化合物16的 Introduction of the a-methyl group into the amino substituent gave the analogue 25 which led to the anticipated increase in b2adrenoceptor affinity, of greater than 10-fold relative to 1.However, this increase in affinity was also accompanied by an even greater relative increase in b1-adrenoceptor affinity and an overall reduction in binding selectivity.
谢谢！！！

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3楼2012-10-24 08:44:25

已阅关注TA 给TA发消息送TA红花 TA的回帖