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ÈçÌâ,Ïë²âһϿǾÛÌÇÔÚ²»Í¬pHֵʱµÄµçÀë¶È¡£ÓÐһƪÎÄÕ½С¶Preparation and characterization of sodium hexameta phosphate cross-linked chitosan microspheres for controlled and sustained delivery of centchroman¡·£¬ËûµÄ·½·¨ÊÇTo determine the pH of maximum interactions between hexameta polyphosphate anions and amino groups of chitosan, the mixture of sodium hexameta polyphosphate (0.1 g l−1) and chitosan (0.2 g l−1) was dissolved in 20 ml 0.01MHCl and titrated with 0.01M NaOH using UV¨Cvis spectrophotometer at ¦Ëmax
420 nm and change in solution pH was recorded. To determine the degree of dissociation, the sodium hexameta polyphosphate (SHMP)was dissolved in excess solution of 0.1MHCl and back titrated with alkali.µ«ÊÇÎҵĽá¹ûºÍÎÄÕ¸øµÄ²»Ò»Ñù¡£Ï£ÍûÄÄλ´óÏÀÖ¸µãһϣ¡
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