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Reviewer: 1
Comments to the Author
Overall, the results of this manuscript are clear and support the conclusions. However, there are several areas that would benefit from further revision.
Reviewer: 2
Comments to the Author
This study is a progress in understanding underlying mechanism of xxx and could shed some light on the treatment of this disease.  There are several points to be addressed by authors for clarity.
Reviewer: 3
Comments to the Author
This study is interesting and has the potential to bring clinically relevant perspectives, especially the extensive documentation part, is valuable and informative to the related area.However, my enthusiasm is somewhat tempered by the lack of mechanistic data. The following issues should be addressed:
Reviewer: 4
Comments to the Author
The experiment design and the data interpretation in this manuscript are fairly done. There are a couple of points which the authors should address.
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