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wangjun007金虫 (正式写手)
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[求助]
介孔硅药物释放
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| 有谁做过介孔硅的药物释放，你们是怎么做的？我是用透析的方法，但发现有沉淀物在透析袋里，这样药物还能出来吗？ |
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wangjun007
金虫 (正式写手)
- 应助: 0 (幼儿园)
- 金币: 1259.2
- 散金: 41
- 帖子: 481
- 在线: 192小时
- 虫号: 1110416
- 注册: 2010-09-28
- 专业: 药物分析
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For the pH dependent release studies, three different buffer solutions with the same NaCl concentration (0.15 M) were chosen: sodium acetate buffer for pH 5.0, phosphate buffer for pH 6.5 and 7.4. DOX@M-MSN–P(NIPAM-co-MAA) was dispersed in 2 mL of buffer, and the dispersion was transferred into a dialysis bag (molecular weight cut off ¼ 14 000). The dialysis bag was then kept in 200 mL of buffer and gently shaken at 37 C. At timed intervals, 1 mL of solution was withdrawn from the solution and analyzed by UV-vis. To keep a constant volume, 1 mL of fresh buffer was added after each sampling. All drug release results were averaged with three measurements,其实文献挺多的，大致就是这么个方法，你要根据具体情况而定 |
5楼2012-12-11 11:49:52
2楼2012-12-07 16:14:37
wangjun007
金虫 (正式写手)
- 应助: 0 (幼儿园)
- 金币: 1259.2
- 散金: 41
- 帖子: 481
- 在线: 192小时
- 虫号: 1110416
- 注册: 2010-09-28
- 专业: 药物分析
3楼2012-12-08 11:47:56
4楼2012-12-10 14:58:39
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