±±¾©Ê¯ÓÍ»¯¹¤Ñ§Ôº2026ÄêÑо¿ÉúÕÐÉú½ÓÊÕµ÷¼Á¹«¸æ
²é¿´: 259  |  »Ø¸´: 0
µ±Ç°Ö÷ÌâÒѾ­´æµµ¡£

zhangxiaohang

ľ³æ (СÓÐÃûÆø)

[½»Á÷] ΢·Û¹è½ºÓ¢¹úÒ©µä

Colloidal Silicon Dioxide


SiO2 60.08

Silica.
Silica [7631-86-9].


» Colloidal Silicon Dioxide is a submicroscopic fumed silica prepared by the vapor-phase hydrolysis of a silicon compound. When ignited at 1000¡ã for 2 hours, it contains not less than 99.0 percent and not more than 100.5 percent of SiO2.

Packaging and storage¡ª Preserve in well-closed containers.

Identification¡ª

A: Transfer about 5 mg to a platinum crucible, and mix with about 200 mg of anhydrous potassium carbonate. Ignite at a red heat over a burner for about 10 minutes, and cool. Dissolve the melt in 2 mL of freshly distilled water, warming if necessary, and slowly add 2 mL of ammonium molybdate TS to the solution: a deep yellow color is produced.

B: [ Caution ¡ª Avoid contact with o-tolidine when performing this test, and conduct the test in a well- ventilated hood. ] Place 1 drop of the yellow silicomolybdate solution obtained in Identification test A on a filter paper, and evaporate the solvent. Add 1 drop of a saturated solution of o-tolidine in glacial acetic acid to reduce the silicomolybdate to molybdenum blue, and place the paper over ammonium hydroxide: a greenish blue spot is produced.

pH ¨¢ 791 ñ : between 3.5 and 5.5, in a 1 in 25 dispersion.

Loss on drying ¨¢ 731 ñ ¡ª Dry it in a tared platinum crucible at 105¡ã for 2 hours: it loses not more than 2.5% of its weight. Retain the dried specimen, in the crucible, for the test for Loss on ignition.


Loss on ignition ¨¢ 733 ñ ¡ª Ignite the portion of Colloidal Silicon Dioxide, retained from the test for Loss on drying, at 1000 ¡À 25¡ã to constant weight: the previously dried Colloidal Silicon Dioxide loses not more than 2.0% of its weight.

Arsenic, Method I ¨¢ 211 ñ¡ª Prepare the Test Preparation as follows. Transfer 2.5 g to a flask, add 50 mL of 3 N hydrochloric acid, and reflux for 30 minutes using a water condenser. Cool, filter with the aid of suction, and transfer the filtrate to a 100-mL volumetric flask. Wash the filter and flask with several portions of hot water, and add the washings to the flask. Cool, dilute with water to volume, and mix: a 15.0-mL portion of this solution, to which 3 mL of hydrochloric acid has been added, meets the requirements of the test, the addition of the 7 N sulfuric acid being omitted. The limit is 8 µg per g.

Organic volatile impurities, Method IV ¨¢ 467 ñ : meets the requirements.

Assay¡ª Transfer about 500 mg of Colloidal Silicon Dioxide to a tared platinum crucible, ignite at 1000 ¡À 25¡ã for 2 hours, cool in a desiccator, and weigh. Add 3 drops of sulfuric acid, and add enough alcohol to just moisten the sample completely. Add 15 mL of hydrofluoric acid, and in a well-ventilated hood evaporate on a hot plate to dryness, using medium heat (95¡ã to 105¡ã) and taking care that the sample does not spatter as dryness is approached. Heat the crucible to a red color with the aid of a Bunsen burner. Ignite the residue at 1000 ¡À 25¡ã for 30 minutes, cool in a desiccator, and weigh. If a residue remains, repeat the procedure, beginning with ¡°add 15 mL of hydrofluoric acid. ¡± The weight lost by the assay specimen, previously ignited at 1000 ¡À 25¡ã, represents the weight of SiO 2 in the portion taken.


Auxiliary Information¡ª
Staff Liaison : Catherine Sheehan, Senior Scientific Associate
Expert Committee : (EMC) Excipients: Monograph Content
USP27¨CNF22 Page 2928
Phone Number : 1-301-816-8262

[ Last edited by ССǿ on 2006-8-28 at 21:54 ]
»Ø¸´´ËÂ¥
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
Ïà¹Ø°æ¿éÌø×ª ÎÒÒª¶©ÔÄÂ¥Ö÷ zhangxiaohang µÄÖ÷Ìâ¸üÐÂ
×î¾ßÈËÆøÈÈÌûÍÆ¼ö [²é¿´È«²¿] ×÷Õß »Ø/¿´ ×îºó·¢±í
[¿¼ÑÐ] 317Çóµ÷¼Á +11 µ°»ÆÏÌÈâôÕ 2026-03-26 11/550 2026-03-31 13:07 by ¼Çʱ¾2026
[¿¼ÑÐ] Ò»Ö¾Ô¸±±»¯085600²ÄÁÏר˶275|ÓÐÎÄÕÂרÀû£üÇóµ÷¼Á +15 Micky11223 2026-03-25 16/800 2026-03-31 12:15 by oooqiao
[¿¼ÑÐ] »úеѧ˶×Ü·Ö317Çóµ÷¼Á£¡£¡£¡£¡ +5 Acaciad 2026-03-25 5/250 2026-03-31 12:04 by ±±·çÖ®Éñ.
[¿¼ÑÐ] ²ÄÁÏ¿ÆÑ§Ó빤³Ìµ÷¼Á +12 ÉîVËÞÉá°É 2026-03-30 13/650 2026-03-31 11:26 by ²»³Ôô~µÄ؈
[¿¼ÑÐ] ¿´¿´ÎÒ£¡301Çóµ÷¼Á 081700 +3 Ò»¸öСÃ÷ͬѧ 2026-03-24 3/150 2026-03-31 09:40 by longlotian
[¿¼ÑÐ] ²ÄÁÏÓ뻯¹¤£¨0856£©304ÇóBÇøµ÷¼Á +6 Çñgl 2026-03-30 10/500 2026-03-31 07:43 by yishunmin
[¿¼ÑÐ] һ־ԸʳƷ¿ÆÑ§Ó빤³Ì083200Çóµ÷¼Á +4 XQTJZ 2026-03-30 4/200 2026-03-31 04:10 by fmesaito
[¿¼ÑÐ] 083000»·¾³¿ÆÑ§Ó빤³Ìµ÷¼Á£¬×Ü·Ö281 +4 ³È×Ó£¨Ê¤Ò⣩ 2026-03-30 4/200 2026-03-31 00:44 by Linzejun
[¿¼ÑÐ] ¹þ¶û±õ¹¤Òµ´óѧ²ÄÁÏÓ뻯¹¤×¨Ë¶378Çóµ÷¼Á +3 Ëþ±ÈÎÚ˹ 2026-03-30 3/150 2026-03-30 22:55 by Î޼ʵIJÝÔ­
[¿¼ÑÐ] Ò»Ö¾Ô¸±±¾©»¯¹¤´óѧ²ÄÁÏÓ뻯¹¤£¨085600£©296Çóµ÷¼Á +25 µ¾ÆÞС±à 2026-03-26 25/1250 2026-03-30 20:11 by µÎµÎÉϰ¶Ñ½
[¿¼ÑÐ] ÉúÎïѧ 296 Çóµ÷¼Á +5 ¶ä¶ä- 2026-03-26 7/350 2026-03-30 20:07 by Ô´_2020
[¿¼ÑÐ] 318Çóµ÷¼Á +7 ³Â³¿79 2026-03-30 7/350 2026-03-30 10:49 by ̽123
[¿¼ÑÐ] Çóµ÷¼Á£¬Ò»Ö¾Ô¸ ÄϾ©º½¿Õº½Ìì´óѧ´óѧ £¬080500²ÄÁÏ¿ÆÑ§Ó빤³Ìѧ˶ +6 @taotao 2026-03-26 7/350 2026-03-30 10:43 by ÎÒÊÇС¿µ
[¿¼ÑÐ] 071000ÉúÎïѧÇóµ÷¼Á£¬³õÊԳɼ¨343 +7 ССÌðÃæÍÅ 2026-03-25 7/350 2026-03-28 20:25 by ÌÆãå¶ù
[¿¼ÑÐ] ±¾¿ÆÐÂÄÜÔ´¿ÆÑ§Ó빤³Ì£¬Ò»Ö¾Ô¸»ªÀíÄܶ¯285Çóµ÷¼Á +3 AZMK 2026-03-27 5/250 2026-03-28 16:19 by xxxsssccc
[¿¼ÑÐ] 081200-314 +3 LILIQQ 2026-03-27 4/200 2026-03-28 09:41 by ±£»¤µØÇòÄãÎÒ×öÆ
[¿¼ÑÐ] Çóµ÷¼Á +4 Áã°Ë# 2026-03-27 4/200 2026-03-27 18:07 by yu221
[¿¼ÑÐ] 274Çóµ÷¼Á +17 ¹Ë¾ÅóÏҪǫÐé 2026-03-24 23/1150 2026-03-27 15:16 by caszguilin
[¿¼ÑÐ] 07»¯Ñ§303Çóµ÷¼Á +5 î£08 2026-03-25 5/250 2026-03-25 22:46 by 418490947
[¿¼ÑÐ] ÍøÂç¿Õ¼ä°²È«0839Õе÷¼Á +4 w320357296 2026-03-25 6/300 2026-03-25 17:59 by 255671
ÐÅÏ¢Ìáʾ
ÇëÌî´¦ÀíÒâ¼û