| 查看: 298 | 回复: 0 | |||
| 当前主题已经存档。 | |||
zhangxiaohang木虫 (小有名气)
|
[交流]
微粉硅胶英国药典
|
||
|
Colloidal Silicon Dioxide SiO2 60.08 Silica. Silica [7631-86-9]. » Colloidal Silicon Dioxide is a submicroscopic fumed silica prepared by the vapor-phase hydrolysis of a silicon compound. When ignited at 1000° for 2 hours, it contains not less than 99.0 percent and not more than 100.5 percent of SiO2. Packaging and storage— Preserve in well-closed containers. Identification— A: Transfer about 5 mg to a platinum crucible, and mix with about 200 mg of anhydrous potassium carbonate. Ignite at a red heat over a burner for about 10 minutes, and cool. Dissolve the melt in 2 mL of freshly distilled water, warming if necessary, and slowly add 2 mL of ammonium molybdate TS to the solution: a deep yellow color is produced. B: [ Caution — Avoid contact with o-tolidine when performing this test, and conduct the test in a well- ventilated hood. ] Place 1 drop of the yellow silicomolybdate solution obtained in Identification test A on a filter paper, and evaporate the solvent. Add 1 drop of a saturated solution of o-tolidine in glacial acetic acid to reduce the silicomolybdate to molybdenum blue, and place the paper over ammonium hydroxide: a greenish blue spot is produced. pH á 791 ñ : between 3.5 and 5.5, in a 1 in 25 dispersion. Loss on drying á 731 ñ — Dry it in a tared platinum crucible at 105° for 2 hours: it loses not more than 2.5% of its weight. Retain the dried specimen, in the crucible, for the test for Loss on ignition. Loss on ignition á 733 ñ — Ignite the portion of Colloidal Silicon Dioxide, retained from the test for Loss on drying, at 1000 ± 25° to constant weight: the previously dried Colloidal Silicon Dioxide loses not more than 2.0% of its weight. Arsenic, Method I á 211 ñ— Prepare the Test Preparation as follows. Transfer 2.5 g to a flask, add 50 mL of 3 N hydrochloric acid, and reflux for 30 minutes using a water condenser. Cool, filter with the aid of suction, and transfer the filtrate to a 100-mL volumetric flask. Wash the filter and flask with several portions of hot water, and add the washings to the flask. Cool, dilute with water to volume, and mix: a 15.0-mL portion of this solution, to which 3 mL of hydrochloric acid has been added, meets the requirements of the test, the addition of the 7 N sulfuric acid being omitted. The limit is 8 µg per g. Organic volatile impurities, Method IV á 467 ñ : meets the requirements. Assay— Transfer about 500 mg of Colloidal Silicon Dioxide to a tared platinum crucible, ignite at 1000 ± 25° for 2 hours, cool in a desiccator, and weigh. Add 3 drops of sulfuric acid, and add enough alcohol to just moisten the sample completely. Add 15 mL of hydrofluoric acid, and in a well-ventilated hood evaporate on a hot plate to dryness, using medium heat (95° to 105°) and taking care that the sample does not spatter as dryness is approached. Heat the crucible to a red color with the aid of a Bunsen burner. Ignite the residue at 1000 ± 25° for 30 minutes, cool in a desiccator, and weigh. If a residue remains, repeat the procedure, beginning with “add 15 mL of hydrofluoric acid. ” The weight lost by the assay specimen, previously ignited at 1000 ± 25°, represents the weight of SiO 2 in the portion taken. Auxiliary Information— Staff Liaison : Catherine Sheehan, Senior Scientific Associate Expert Committee : (EMC) Excipients: Monograph Content USP27–NF22 Page 2928 Phone Number : 1-301-816-8262 [ Last edited by 小小强 on 2006-8-28 at 21:54 ] |
回复此楼» 猜你喜欢
巴黎萨克雷大学与国家留学基金委合作博士研究生项目-脂质纳米药物/生物材料/多酚递送
已经有10人回复
-
广西医科大学基础医学院自身免疫病课题组招收基础医学相关专业的调剂研究生
已经有2人回复
-
药物学论文润色/翻译怎么收费?
已经有118人回复
-
锦州医科大学药用生物材料（专业代码1007Z1）招收调剂考生
已经有0人回复
-
锦州医科大学药用生物材料（专业代码1007Z1）招收调剂考生
已经有2人回复
-
26申博自荐
已经有12人回复
-
SUES&NERCN课题组接受硕士生调剂 (学硕1名+专硕1名)
已经有0人回复
-
SUES&NERCN课题组接受硕士生调剂 (学硕1名+专硕1名)
已经有0人回复
-
SUES&NERCN课题组接受硕士生调剂 (学硕1名+专硕1名)
已经有0人回复
-
广西医科大学基础医学院招收基础医学、药学、生物检验相关专业的研究生
已经有1人回复
-
求大佬收留
已经有0人回复
30