| 查看: 1195 | 回复: 6 | |||
| 本帖产生 1 个 翻译EPI ，点击这里进行查看 | |||
1121prettycat木虫 (正式写手)
|
[交流]
求助翻译 细胞内分泌方面，每句话三到十二 个金币
|
||
|
CYP11A catalyzes the side-chain cleavage of cholesterol, which is the starting point of steroid synthesis and it is also the rate-limiting step. CYP11B2 catalyzes the biosynthesis of the glucocorticoid cortisol from 11-deoxycortisol, which has numerous metabolic, developmental, immunosuppressive, anti-inflammatory and other functions in the body。 CYP17 catalyzes the conversion of aldosterone to corticosteroid substrates and ultimately to sex steroid substrates, which is the initial step of cortisol biosynthesis. Therefore, it is possible that this enzyme can redirect steroid output from mineralocorticoids to glucocorticoids or weak androgens, whereas inhibition of CYP17 would have the opposite effect The CYP21 gene is required for the synthesis of both aldosterone and corticosteroids. Induction of CYP21 may lead to an increase in the synthesis of cortisol and aldosterone, and may result in a decrease in the availability of substrates for androgen and estrogen production HSD enzymes are members of the short-chain alcohol dehydrogenase (SCAD) enzyme family. HSD enzymes mainly catalyze two reactions: (1) the oxidation of a secondary alcohol to a ketone; and (2) the reduction of a ketone to a secondary alcohol. 3bHSD oxidizes a 3b-OH group to a C3 ketone that is an obligate step in the biosynthesis of androgens and estrogens as well as mineralocorticoids and glucocorticoids. 17b-Hydroxysteroid dehydrogenases (17HSDs) are a group of enzymes responsible for the interconversion between low-activity 17-ketosteroids and high-activity 17b-hydroxysteroids. They act as key enzymes modulating the biosynthesis and metabolism of both estrogens and androgens. The protein encoded by the StAR gene plays a key role in the acute regulation of steroid hormone synthesis. It enhances the conversion of cholesterol to pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. |
回复此楼» 猜你喜欢
2027广东省杰青
已经有9人回复
-
朋友圈看到的
已经有5人回复
-
欢迎发来filecode的Mz6后的代码验证其规律
已经有110人回复
-
明天放榜？
已经有5人回复
-
时间戳变了，能看出什么问题？
已经有11人回复
-
重要消息，中午系统在维护
已经有10人回复
-
两姐妹，一个辛辛苦苦30岁工作当大学教师，另一个23岁就工作当开车教练
已经有7人回复
-
投稿咨询
已经有6人回复
-
时间戳又变了8-15
已经有26人回复
-
今天维护系统维护 祝所有人 高中
已经有9人回复
2楼2010-10-14 23:37:51
3楼2010-10-14 23:50:20
4楼2010-10-14 23:54:43
5楼2010-10-14 23:56:47
6楼2010-10-17 00:36:35
7楼2010-10-17 00:36:53
