24小时热门版块排行榜    

Znn3bq.jpeg
查看: 1065  |  回复: 6
本帖产生 1 个 翻译EPI ,点击这里进行查看
当前只显示满足指定条件的回帖,点击这里查看本话题的所有回帖

1121prettycat

木虫 (正式写手)

[交流] 求助翻译 细胞内分泌方面,每句话三到十二 个金币

CYP11A catalyzes the side-chain cleavage of cholesterol, which is the starting point of steroid synthesis and it is also the rate-limiting step.

CYP11B2 catalyzes the biosynthesis of the glucocorticoid cortisol from 11-deoxycortisol, which has numerous metabolic, developmental, immunosuppressive, anti-inflammatory and other functions in the body。

CYP17 catalyzes the conversion of aldosterone to corticosteroid substrates and ultimately to sex steroid substrates, which is the initial step of cortisol biosynthesis.
Therefore, it is possible that this enzyme can redirect steroid output from mineralocorticoids to glucocorticoids or weak androgens, whereas inhibition of CYP17 would have the opposite effect

The CYP21 gene is required for the synthesis of both aldosterone and corticosteroids. Induction of CYP21 may lead to an increase in the synthesis of cortisol and aldosterone, and may result in a decrease in the availability of substrates for androgen and estrogen production

HSD enzymes are members of the short-chain alcohol dehydrogenase (SCAD) enzyme family. HSD enzymes mainly catalyze two reactions: (1) the oxidation of a secondary alcohol to a ketone; and (2) the reduction of a ketone to a secondary alcohol. 3bHSD oxidizes a 3b-OH group to a C3 ketone that is an obligate step in the biosynthesis of androgens and estrogens as well as mineralocorticoids
and glucocorticoids. 17b-Hydroxysteroid dehydrogenases (17HSDs) are a group of enzymes responsible for the interconversion between low-activity 17-ketosteroids and high-activity 17b-hydroxysteroids. They act as key enzymes modulating the biosynthesis and metabolism of both estrogens and androgens.

The protein encoded by the StAR gene plays a key role in the acute regulation of steroid hormone synthesis. It enhances the conversion of cholesterol to pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane.

» 猜你喜欢

已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

graper

银虫 (小有名气)

1121prettycat(金币+21):谢谢谢谢,太谢谢了 2010-10-17 12:43:32
HSD酶是短链醇脱氢酶族(SCAD)的成员。HSD主要催化两种反应:(1)氧化仲醇为酮;(2)将酮还原为仲醇。3bHSD氧化3b位的羟基为C3位酮基,这步反应是雌雄激素以及盐糖皮质激素生物合成的必须步骤。17b羟基固醇脱氢酶(17HSDs)是一组催化低活力17-甾酮与高活力17b-羟甾类相互转化的酶。他们是调节雌雄激素生物合成及代谢的关键酶。
6楼2010-10-17 00:36:35
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
查看全部 7 个回答

graper

银虫 (小有名气)


wypward(金币+1):谢谢参与 2010-10-16 09:26:41
1121prettycat(金币+6, 翻译EPI+1): 2010-10-16 11:25:02
CYP11B2催化胆固醇的侧链剪切,这是固醇类合成的起始并且是限速步骤。

CYP11B2催化了11-脱氧皮质醇生成糖皮质醇的生物合成过程,而糖皮质醇在身体中发挥代谢,发育,免疫抑制,产生发炎和其他作用。
2楼2010-10-14 23:37:51
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

graper

银虫 (小有名气)

1121prettycat(金币+9): 2010-10-16 11:25:10
CYP17催化了醛固酮转化为皮质类固醇底物并且最终转化为性激素底物,这是皮质醇生物合成的第一步。
因此,可能这种酶可以改变盐皮质激素转为糖皮质激素的量,或是减少雄性激素的量,但是抑制CYP17可能有相反的效果。
3楼2010-10-14 23:50:20
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

graper

银虫 (小有名气)

1121prettycat(金币+3): 2010-10-16 11:25:17
CYP21基因是醛固酮和皮质类固醇合成必需的。诱导CYP21可以提高醛固酮和皮质醇的合成量,可能导致用于合成雌雄激素的底物量减少。
4楼2010-10-14 23:54:43
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
普通表情 高级回复 (可上传附件)
最具人气热帖推荐 [查看全部] 作者 回/看 最后发表
[考研] 求调剂 +9 翩翩一书生 2026-04-09 9/450 2026-04-10 11:43 by wp06
[考研] 机械还有还有名额吗?太难了 +5 笑笑袁 2026-04-10 5/250 2026-04-10 11:11 by zhouyuwinner
[考研] 材料调剂 +5 hzhahg 2026-04-06 5/250 2026-04-10 10:10 by may_新宇
[考研] 一志愿华东师范生物学326分,求调剂 +7 刘墨墨 2026-04-09 7/350 2026-04-10 09:59 by 学zh
[考研] 调剂 化学 307 +12 73372112 2026-04-09 13/650 2026-04-10 08:41 by 探123
[考研] 070300化学 求调剂 +13 73372112 2026-04-08 13/650 2026-04-09 20:22 by maddjdld
[考研] 085801 总分275 本科新能源 求调剂 +8 bradoner 2026-04-08 9/450 2026-04-09 13:43 by only周
[考研] 招收有机化学、化工,药学,食品灯专业学生 +3 yrfhjgdj 2026-04-08 3/150 2026-04-09 10:15 by QYQX_123
[考研] 一志愿华东理工085601材料工程303分求调剂 +15 a1708 2026-04-06 15/750 2026-04-08 16:23 by luoyongfeng
[考博] 申博 +8 IQwQl 2026-04-04 8/400 2026-04-08 09:43 by 0608104024
[考研] 求调剂 +28 111623 2026-04-04 33/1650 2026-04-08 09:24 by 泽润东方
[考研] 344求调剂 +11 魏子per 2026-04-07 11/550 2026-04-07 23:01 by JourneyLucky
[考研] 生物学363调剂求助 +7 fanzhang6666 2026-04-06 9/450 2026-04-07 17:37 by lijunpoly
[考研] 一志愿北京化工085600 310分求调剂 +20 0856材料与化工3 2026-04-04 22/1100 2026-04-07 15:14 by 上岸快快
[考研] 22408 318分求调剂 +4 勤奋的小笼包 2026-04-06 6/300 2026-04-07 15:05 by 纸鹤555
[考研] 305分求调剂 +3 哈_哈_哈_哈_哈 2026-04-04 5/250 2026-04-07 14:49 by 哈_哈_哈_哈_哈
[考研] 软工学硕299求调剂 +6 useryy 2026-04-07 6/300 2026-04-07 09:50 by vgtyfty
[考研] 312求调剂 +4 LR6 2026-04-06 4/200 2026-04-07 08:42 by jp9609
[考研] 285求调剂 +5 mapmath 2026-04-06 6/300 2026-04-06 17:18 by 蓝云思雨
[考研] 288求调剂 一志愿哈工大 材料与化工 +13 洛神哥哥 2026-04-03 13/650 2026-04-05 17:27 by zzx2138
信息提示
请填处理意见