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1121prettycat

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[交流] 求助翻译 细胞内分泌方面,每句话三到十二 个金币

CYP11A catalyzes the side-chain cleavage of cholesterol, which is the starting point of steroid synthesis and it is also the rate-limiting step.

CYP11B2 catalyzes the biosynthesis of the glucocorticoid cortisol from 11-deoxycortisol, which has numerous metabolic, developmental, immunosuppressive, anti-inflammatory and other functions in the body。

CYP17 catalyzes the conversion of aldosterone to corticosteroid substrates and ultimately to sex steroid substrates, which is the initial step of cortisol biosynthesis.
Therefore, it is possible that this enzyme can redirect steroid output from mineralocorticoids to glucocorticoids or weak androgens, whereas inhibition of CYP17 would have the opposite effect

The CYP21 gene is required for the synthesis of both aldosterone and corticosteroids. Induction of CYP21 may lead to an increase in the synthesis of cortisol and aldosterone, and may result in a decrease in the availability of substrates for androgen and estrogen production

HSD enzymes are members of the short-chain alcohol dehydrogenase (SCAD) enzyme family. HSD enzymes mainly catalyze two reactions: (1) the oxidation of a secondary alcohol to a ketone; and (2) the reduction of a ketone to a secondary alcohol. 3bHSD oxidizes a 3b-OH group to a C3 ketone that is an obligate step in the biosynthesis of androgens and estrogens as well as mineralocorticoids
and glucocorticoids. 17b-Hydroxysteroid dehydrogenases (17HSDs) are a group of enzymes responsible for the interconversion between low-activity 17-ketosteroids and high-activity 17b-hydroxysteroids. They act as key enzymes modulating the biosynthesis and metabolism of both estrogens and androgens.

The protein encoded by the StAR gene plays a key role in the acute regulation of steroid hormone synthesis. It enhances the conversion of cholesterol to pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane.

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graper

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1121prettycat(金币+3): 2010-10-16 11:25:17
CYP21基因是醛固酮和皮质类固醇合成必需的。诱导CYP21可以提高醛固酮和皮质醇的合成量,可能导致用于合成雌雄激素的底物量减少。
4楼2010-10-14 23:54:43
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graper

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wypward(金币+1):谢谢参与 2010-10-16 09:26:41
1121prettycat(金币+6, 翻译EPI+1): 2010-10-16 11:25:02
CYP11B2催化胆固醇的侧链剪切,这是固醇类合成的起始并且是限速步骤。

CYP11B2催化了11-脱氧皮质醇生成糖皮质醇的生物合成过程,而糖皮质醇在身体中发挥代谢,发育,免疫抑制,产生发炎和其他作用。
2楼2010-10-14 23:37:51
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graper

银虫 (小有名气)

1121prettycat(金币+9): 2010-10-16 11:25:10
CYP17催化了醛固酮转化为皮质类固醇底物并且最终转化为性激素底物,这是皮质醇生物合成的第一步。
因此,可能这种酶可以改变盐皮质激素转为糖皮质激素的量,或是减少雄性激素的量,但是抑制CYP17可能有相反的效果。
3楼2010-10-14 23:50:20
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graper

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1121prettycat(金币+1):拜托楼上的大侠将其余几句一起翻译了吧,高手啊 2010-10-16 11:25:46
一边看电影一边翻的   其他的别人来吧
5楼2010-10-14 23:56:47
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