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虫号: 332475
注册: 2007-03-26
专业: 模式识别

[交流] 博士后机会——美国肯塔基州

A PostDoc position available in Prof. Chi Li's lab at University of Louisville,KY,USA.

Prof. Li is a very smart scientist and a very nice person. He achieved his B.S from University of Science & Technology of China in 1991 and Ph.D from Columbia University in 1998. Now he is associate professor of UofL. His research focus on molecular targets.

Research Interests:
One of the hallmarksof cancer is the inhibition of apoptosis, a tightly controlled cellular suicide program. Among the major regulators of cellular responses to intrinsic and extrinsic apoptotic stimuli is the Bcl-2 family of proteins. Experiments conducted in this laboratory are designed to elucidate the detailed molecular mechanisms of how Bcl-2 proteins regulate apoptotic signaling pathways initiated from different intracellular organelles. We hope that better understanding of functions of Bcl-2 proteins during apoptosis will contribute to the development of new cancer treatments.

Selected publications:
Li, C. and  Manley, J.L. Even-skipped represses transcription by binding TBP and blocking the TFIID-TATA box interaction. Mol. Cell Biol. 18: 3771-3781, 1998.
Li, C. and  Manley, J.L.  Allosteric regulation of Even-Skipped repression activity by phosphorylation. Mol. Cell. 3: 77-86, 1999.
Li, C., Fox, C.J., Master, S.R., Bindokas, V.P., Chodosh, L.A. and Thompson, C.B.  Bcl-XL affects Ca2+ homeostasis by regulating expression of inositol 1,4,5-triphosphate receptor. Proc. Natl. Acad. Sci. USA. 99: 9830-9835, 2002.
Li, C. and Thompson, C.B.  DNA damage, deamidation, and death.  Science.  298: 1346-1347, 2002.
Lum, J.J., Bauer, D.E., Kong, M., Harris, M.H., Li, C., Lindsten, T., and Thompson, C.B.  Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell. 120: 237-248, 2005.
Oltersdorf, T., Elmore, S.W., Shoemaker, A.R., Armstrong, R.C., Augeri, D., Belli, B.A., Bruncko, M., Deckwerth, T.L., Dinges, J., Hajduk, P.J., Joseph, M.K., Kitada, S., Korsmeyer, S.J.,  Kunzer, A.R., Leita, A., Li, C., Mitten, M.J., Nettesheim, D.G., Ng, S., Nimmer, P.M., O'Connor, J.M., Oleksijew, A., Petros, A.M., Reed, J.C., Shen, W., Tahir, S.K., Thompson, C.B., Tomaselli, K.J., Wang, B., Wendt, M.D., Zhang, H., Fesik, S.W. and Rosenberg, S.H. An inhibitor of Bcl-2 family proteins induces regression of solid tumors.  Nature. 435: 677-681, 2005.
White, C.*, Li, C*., Yang, J., Petrenko, N.B., Madesh, M, Thompson, C.B., and Foskett, K.J.. The endoplasmic reticulum gateway to apoptosis: Bcl-XL modulation of the InsP3.  Nature Cell Biol.  10: 1021-1028, 2005 (* The first  two authors contributed equally to the paper).
Li C, Wang X, Vais H, Thompson CB, Foskett JK, White C. Apoptosis regulation by Bcl-xL modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating. Proc Natl Acad Sci USA 104:12565-70, 2007.

If anyone is interested in this position, please send a resume to wangbing@ustc.edu as soon as possible

Thanks!

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