| 查看: 1553 | 回复: 19 | |||
| 【有奖交流】积极回复本帖子，参与交流，就有机会分得作者 Strawberrix 的 1 个金币 ，回帖就立即获得 1 个金币，每人有 1 次机会 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
[交流]
系统生物学读博全奖，CSC-University Maastricht 项目 2
|
|||
|
和csc的项目。感兴趣者请将英文版cv和transcript发送至 Prof. Dr. Renaud Jolivet (r.jolivet@maastrichtuniversity.nl) 或 dr. marian breuer （marian.breuer@maastrichtuniversity.nl） 并向他直接咨询其他信息。 Project title: Modeling the Metabolic Diversity of the Brain’s Glial Cells Project leader: Prof. Dr. Renaud Jolivet, Dr. Marian Breuer Function: Professor of Neural Engineering and Computation Collaborators: Prof. Dr. Ilja Arts Proposal (250 words): Introduction: The brain consists of a variety of cell types, and neurons only constitute around half of the brain cell population. The other cell populations, collectively known as glial cells, support and interact with neurons in various ways. Glial cells play a pivotal role in normal brain function as well as neurodegenerative and other disorders, and thus their understanding is of importance in the context of public health. However, while glial cells are known to play an important role in brain metabolism overall, their particular metabolic functions and interactions are far from understood. Hypothesis and Objectives: This project will study the metabolic functions of different types of glial cells, as well as their metabolic interactions, and how these are affected in aging and different pathological conditions. Setting and Methods: The project will make use of large publicly available neuroscience transcriptome data sets to build models of the metabolic network of various types of glial cells, and to study how these glial cells interact with each other in the brain. The project will then make use of other transcriptomes to investigate these interactions in aging and in various diseases of the central nervous system. Impact: The metabolic functions and interactions of glial cells in normal brain function address an important knowledge gap in basic neuroscience; while their perturbations in aging, neurodegenerative diseases and other pathological conditions could help to elucidate disease mechanisms as well as suggest potential intervention strategies – with strong potential impact in healthy aging and disease diagnosis and therapy. Requirements candidate: Highly motivated student with good English communication skills and proactive and resolute attitude. The project requires good programming skills and an interest for the complexity and diversity of the brain’s heterocellular population. The ideal candidate would have a foundation in biochemistry and cellular metabolism on the one hand, and some computational skills on the other hand, preferably in Matlab. Applications with background in only the biochemical or computational side are still welcome, if the applicant can make a case for being able to catch up in the other aspect. Keywords: Biological Foundations of Human Health and Diseases, Computational Biology, Systems Biology, Metabolic Modeling, Neuroscience, Aging Top 5 selected publications: 1. Cullen CL, Pepper RE, Clutterbuck MT, Pitman KA, Oorschot V, Auderset L, Tang AD, Ramm G, Emery B, Rodger J, Jolivet RB & Young KM “Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain” Cell Rep. (2021), 34:108641. Citations (Web of Science): 7 2. Caruso G, Caraci F & Jolivet RB “Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders” Progress in Neurobiol. (2019), 175:35. Citations (Web of Science): 29 3. Madry C*, Kyrargyri V*, Arancibia-Cárcamo IL*, Jolivet RB*, Kohsaka S, Bryan RM & Attwell D “Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1” Neuron (2018), 97:299. Citations (Web of Science): 146, top 1% cited in Neuroscience & Behaviour 4. M. Breuer, T. M. Earnest, C. Merryman, K. S. Wise, L. Sun, M. R. Lynott, C. A. Hutchison III, H. O. Smith, J. D. Lapek Jr., D. J. Gonzalez, V. de Crécy-Lagard, D. Haas, A. D. Hanson, P. Labhsetwar, J. I. Glass, Z. Luthey-Schulten “Essential Metabolism for a Minimal Cell” eLife (2019), 8:e36842. Citations (Web of Science): 37 5. C. Sarathy, M. Breuer, M. Kutmon, M. E. Adriaens, C. T. Evelo, I. C. W. Arts “Comparison of metabolic states using genome-scale metabolic models” PLOS Comp. Biol. (2021), 17:e1009522. Additional details - Duration: Four years - No mandatory course work - English: Good score on TOEFL, IELTS or other test beneficial, but English language skills will be gauged primarily during personal interview - Cooperative program - Maastricht University has limited number of reserved spots; beyond these, application through general program possible - Further information: - www.maastrichtuniversity.nl/um-china-team#um-csc - www.maastrichtuniversity.nl/phd-project-outlines - Contact details: - Dr. Marian Breuer: marian.breuer@maastrichtuniversity.nl - Prof. Dr. Renaud Jolivet: r.jolivet@maastrichtuniversity.nl |
回复此楼» 猜你喜欢
278求调剂
已经有4人回复
-
新疆大学地质与矿业工程学院招生
已经有14人回复
-
材料化工求调剂
已经有4人回复
-
288求调剂085600材料与化工
已经有5人回复
-
一志愿南京大学资源与环境专业283分求调剂
已经有8人回复
-
085600材料与化工 292分 求调剂
已经有6人回复
-
材料调剂
已经有12人回复
-
334求调剂
已经有6人回复
-
申博
已经有6人回复
-
接受26届调剂生
已经有14人回复
» 抢金币啦！回帖就可以得到:
-
江西师大化学工程学院2026招收化学化工相关调剂生110+人
+2/844
-
南京林业大学化工院勇强/赖晨欢教授团队招收申请考核制博士
+1/83
-
济大前沿 逄老师招收调剂：1名化学学硕、1名化工专硕 欢迎发邮件
+1/81
-
2026药物化学博士招生
+1/76
-
2026年青岛理工大学暖通专业硕士生招生_081404；0852；081300方向
+2/40
-
诚征女友 #西安
+1/32
-
坐标南京或周边附近
+1/22
-
华中科技大学牛广达教授招聘博士后
+1/13
-
绿色催化氧化团队接收调剂研究生
+1/11
-
求调剂 初试338 0824船舶 求控制、机械、船舶调剂
+1/10
-
鲁东大学水产养殖0908 有调剂名额，需要调剂联系
+1/10
-
青岛科技大学-材料学院-青年泰山学者团队招收多名硕士及调剂生-欢迎咨询！
+1/9
-
安徽农业大学许云辉教授课题组招收材料类、化工类、医学类等工科专硕学硕考研调剂
+1/8
-
青岛科技大学化工学院毕荣山课题组招收2026级一志愿硕士研究生
+1/8
-
【博士招生】北方工业大学招收 机械工程方向 申请考核制博士
+1/6
-
深圳大学何传新课题组诚聘博士后、（副）研究员
+1/5
-
26届计算机、电子信息类、电科、控制、通信考研T j信息pp骏：74+08+76+6+20/
+1/4
-
北京高校副校长团队招收机械类，环境类学硕和专硕
+1/2
-
知名外资仪器厂家急招Application Scientist-成都
+1/2
-
紧急博士招生 福建农林大学 生物质化学工程与机能材料团队招收申请博士1名
+1/1
5楼2022-09-19 15:51:10
6楼2022-09-19 18:55:41
9楼2022-09-21 16:29:44
10楼2022-09-21 21:51:59
简单回复
XG-WUST4楼
2022-09-19 12:54
回复
Strawberrix(金币+1): 谢谢参与
up 发自小木虫IOS客户端
