| 查看: 1558 | 回复: 19 | |||
| 【有奖交流】积极回复本帖子，参与交流，就有机会分得作者 Strawberrix 的 1 个金币 ，回帖就立即获得 1 个金币，每人有 1 次机会 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
[交流]
系统生物学读博全奖，CSC-University Maastricht 项目 2
|
|||
|
和csc的项目。感兴趣者请将英文版cv和transcript发送至 Prof. Dr. Renaud Jolivet (r.jolivet@maastrichtuniversity.nl) 或 dr. marian breuer （marian.breuer@maastrichtuniversity.nl） 并向他直接咨询其他信息。 Project title: Modeling the Metabolic Diversity of the Brain’s Glial Cells Project leader: Prof. Dr. Renaud Jolivet, Dr. Marian Breuer Function: Professor of Neural Engineering and Computation Collaborators: Prof. Dr. Ilja Arts Proposal (250 words): Introduction: The brain consists of a variety of cell types, and neurons only constitute around half of the brain cell population. The other cell populations, collectively known as glial cells, support and interact with neurons in various ways. Glial cells play a pivotal role in normal brain function as well as neurodegenerative and other disorders, and thus their understanding is of importance in the context of public health. However, while glial cells are known to play an important role in brain metabolism overall, their particular metabolic functions and interactions are far from understood. Hypothesis and Objectives: This project will study the metabolic functions of different types of glial cells, as well as their metabolic interactions, and how these are affected in aging and different pathological conditions. Setting and Methods: The project will make use of large publicly available neuroscience transcriptome data sets to build models of the metabolic network of various types of glial cells, and to study how these glial cells interact with each other in the brain. The project will then make use of other transcriptomes to investigate these interactions in aging and in various diseases of the central nervous system. Impact: The metabolic functions and interactions of glial cells in normal brain function address an important knowledge gap in basic neuroscience; while their perturbations in aging, neurodegenerative diseases and other pathological conditions could help to elucidate disease mechanisms as well as suggest potential intervention strategies – with strong potential impact in healthy aging and disease diagnosis and therapy. Requirements candidate: Highly motivated student with good English communication skills and proactive and resolute attitude. The project requires good programming skills and an interest for the complexity and diversity of the brain’s heterocellular population. The ideal candidate would have a foundation in biochemistry and cellular metabolism on the one hand, and some computational skills on the other hand, preferably in Matlab. Applications with background in only the biochemical or computational side are still welcome, if the applicant can make a case for being able to catch up in the other aspect. Keywords: Biological Foundations of Human Health and Diseases, Computational Biology, Systems Biology, Metabolic Modeling, Neuroscience, Aging Top 5 selected publications: 1. Cullen CL, Pepper RE, Clutterbuck MT, Pitman KA, Oorschot V, Auderset L, Tang AD, Ramm G, Emery B, Rodger J, Jolivet RB & Young KM “Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain” Cell Rep. (2021), 34:108641. Citations (Web of Science): 7 2. Caruso G, Caraci F & Jolivet RB “Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders” Progress in Neurobiol. (2019), 175:35. Citations (Web of Science): 29 3. Madry C*, Kyrargyri V*, Arancibia-Cárcamo IL*, Jolivet RB*, Kohsaka S, Bryan RM & Attwell D “Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1” Neuron (2018), 97:299. Citations (Web of Science): 146, top 1% cited in Neuroscience & Behaviour 4. M. Breuer, T. M. Earnest, C. Merryman, K. S. Wise, L. Sun, M. R. Lynott, C. A. Hutchison III, H. O. Smith, J. D. Lapek Jr., D. J. Gonzalez, V. de Crécy-Lagard, D. Haas, A. D. Hanson, P. Labhsetwar, J. I. Glass, Z. Luthey-Schulten “Essential Metabolism for a Minimal Cell” eLife (2019), 8:e36842. Citations (Web of Science): 37 5. C. Sarathy, M. Breuer, M. Kutmon, M. E. Adriaens, C. T. Evelo, I. C. W. Arts “Comparison of metabolic states using genome-scale metabolic models” PLOS Comp. Biol. (2021), 17:e1009522. Additional details - Duration: Four years - No mandatory course work - English: Good score on TOEFL, IELTS or other test beneficial, but English language skills will be gauged primarily during personal interview - Cooperative program - Maastricht University has limited number of reserved spots; beyond these, application through general program possible - Further information: - www.maastrichtuniversity.nl/um-china-team#um-csc - www.maastrichtuniversity.nl/phd-project-outlines - Contact details: - Dr. Marian Breuer: marian.breuer@maastrichtuniversity.nl - Prof. Dr. Renaud Jolivet: r.jolivet@maastrichtuniversity.nl |
回复此楼» 猜你喜欢
调剂
已经有5人回复
-
材料调剂
已经有15人回复
-
288求调剂085600材料与化工
已经有13人回复
-
调剂的同学，走过路过，不要错过
已经有13人回复
-
中科大材料299求调剂
已经有15人回复
-
0701-322 求调剂
已经有4人回复
-
0703求调剂
已经有7人回复
-
理学287分求调剂
已经有3人回复
-
A区一本交叉课题组，低分调剂，招收机械电子信息通信等交叉方向
已经有55人回复
-
一志愿南大化学339分求调剂，四六级已过，有比赛，有文章
已经有3人回复
» 抢金币啦！回帖就可以得到:
-
南京工业大学杨建教授联合苏州实验室/上硅所联合培养博生研究生
+1/183
-
中科院赣江创新研究院-江西理工大学2026年联合培养博士研究生招生(电化学储能)
+1/181
-
化学/材料研究方向湖北省级实验室招收硕士研究生
+1/149
-
Ph.D. Opportunity in Mechanical Engineering – Fall 2026
+2/144
-
中国科学院-材料计算小组寻求2026级研究生（包括调剂生/联合培养等）
+5/115
-
长江大学武汉校区石油工程学院人才招聘-2026
+1/40
-
智能材料创制/超分子化学/柔性光电子材料方向招收研究生
+2/38
-
（目前仅考虑招收报考南理工化院的考生，调剂的先等等）赵健课题组硕士招生
+1/33
-
中国石油大学（北京）王郁现教授课题组招收化学工程与技术/环境化工方向博士生
+1/33
-
【博士招生】武汉科技大学招收材料、化工、环境、冶金类2026年“申请-考核”制博士生
+1/15
-
英国兰卡斯特大学（Lancaster University）大模型、计算机视觉PhD招生
+1/10
-
中南林业科技大学《微生物学》2026年博士生招生（“申请-审核”录取）
+1/8
-
211/双一流-电池/电催化研究方向-化工+化学+材料化工
+1/7
-
副总监/总监 – 北亚区
+1/5
-
中科院微生物所-肿瘤免疫或微生物组方向的博士后（特别研究助理）
+1/5
-
求调剂学校推荐，机械专硕342
+1/4
-
中南林业科技大学生物质绿色转化与功能材料课题组现招收2026年秋季入学博士研究生
+1/3
-
西安工程大学环境与化学工程学院26年硕士研究生招生咨询（26年9月入学）
+1/3
-
大湾区大学姚瑶课题组2026届博士生招生
+1/3
-
武汉科技大学周志辉教授团队招师资博后（膜分离方向）
+1/1
10楼2022-09-21 21:51:59
5楼2022-09-19 15:51:10
6楼2022-09-19 18:55:41
9楼2022-09-21 16:29:44
简单回复
XG-WUST4楼
2022-09-19 12:54
回复
Strawberrix(金币+1): 谢谢参与
up 发自小木虫IOS客户端
