| 查看: 1525 | 回复: 19 | |||
| 【有奖交流】积极回复本帖子，参与交流，就有机会分得作者 Strawberrix 的 1 个金币 ，回帖就立即获得 1 个金币，每人有 1 次机会 | |||
[交流]
系统生物学读博全奖，CSC-University Maastricht 项目 2
|
|||
|
和csc的项目。感兴趣者请将英文版cv和transcript发送至 Prof. Dr. Renaud Jolivet (r.jolivet@maastrichtuniversity.nl) 或 dr. marian breuer （marian.breuer@maastrichtuniversity.nl） 并向他直接咨询其他信息。 Project title: Modeling the Metabolic Diversity of the Brain’s Glial Cells Project leader: Prof. Dr. Renaud Jolivet, Dr. Marian Breuer Function: Professor of Neural Engineering and Computation Collaborators: Prof. Dr. Ilja Arts Proposal (250 words): Introduction: The brain consists of a variety of cell types, and neurons only constitute around half of the brain cell population. The other cell populations, collectively known as glial cells, support and interact with neurons in various ways. Glial cells play a pivotal role in normal brain function as well as neurodegenerative and other disorders, and thus their understanding is of importance in the context of public health. However, while glial cells are known to play an important role in brain metabolism overall, their particular metabolic functions and interactions are far from understood. Hypothesis and Objectives: This project will study the metabolic functions of different types of glial cells, as well as their metabolic interactions, and how these are affected in aging and different pathological conditions. Setting and Methods: The project will make use of large publicly available neuroscience transcriptome data sets to build models of the metabolic network of various types of glial cells, and to study how these glial cells interact with each other in the brain. The project will then make use of other transcriptomes to investigate these interactions in aging and in various diseases of the central nervous system. Impact: The metabolic functions and interactions of glial cells in normal brain function address an important knowledge gap in basic neuroscience; while their perturbations in aging, neurodegenerative diseases and other pathological conditions could help to elucidate disease mechanisms as well as suggest potential intervention strategies – with strong potential impact in healthy aging and disease diagnosis and therapy. Requirements candidate: Highly motivated student with good English communication skills and proactive and resolute attitude. The project requires good programming skills and an interest for the complexity and diversity of the brain’s heterocellular population. The ideal candidate would have a foundation in biochemistry and cellular metabolism on the one hand, and some computational skills on the other hand, preferably in Matlab. Applications with background in only the biochemical or computational side are still welcome, if the applicant can make a case for being able to catch up in the other aspect. Keywords: Biological Foundations of Human Health and Diseases, Computational Biology, Systems Biology, Metabolic Modeling, Neuroscience, Aging Top 5 selected publications: 1. Cullen CL, Pepper RE, Clutterbuck MT, Pitman KA, Oorschot V, Auderset L, Tang AD, Ramm G, Emery B, Rodger J, Jolivet RB & Young KM “Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain” Cell Rep. (2021), 34:108641. Citations (Web of Science): 7 2. Caruso G, Caraci F & Jolivet RB “Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders” Progress in Neurobiol. (2019), 175:35. Citations (Web of Science): 29 3. Madry C*, Kyrargyri V*, Arancibia-Cárcamo IL*, Jolivet RB*, Kohsaka S, Bryan RM & Attwell D “Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1” Neuron (2018), 97:299. Citations (Web of Science): 146, top 1% cited in Neuroscience & Behaviour 4. M. Breuer, T. M. Earnest, C. Merryman, K. S. Wise, L. Sun, M. R. Lynott, C. A. Hutchison III, H. O. Smith, J. D. Lapek Jr., D. J. Gonzalez, V. de Crécy-Lagard, D. Haas, A. D. Hanson, P. Labhsetwar, J. I. Glass, Z. Luthey-Schulten “Essential Metabolism for a Minimal Cell” eLife (2019), 8:e36842. Citations (Web of Science): 37 5. C. Sarathy, M. Breuer, M. Kutmon, M. E. Adriaens, C. T. Evelo, I. C. W. Arts “Comparison of metabolic states using genome-scale metabolic models” PLOS Comp. Biol. (2021), 17:e1009522. Additional details - Duration: Four years - No mandatory course work - English: Good score on TOEFL, IELTS or other test beneficial, but English language skills will be gauged primarily during personal interview - Cooperative program - Maastricht University has limited number of reserved spots; beyond these, application through general program possible - Further information: - www.maastrichtuniversity.nl/um-china-team#um-csc - www.maastrichtuniversity.nl/phd-project-outlines - Contact details: - Dr. Marian Breuer: marian.breuer@maastrichtuniversity.nl - Prof. Dr. Renaud Jolivet: r.jolivet@maastrichtuniversity.nl |
回复此楼» 猜你喜欢
材料调剂
已经有4人回复
-
面上模板改不了页边距吧？
已经有6人回复
-
307求调剂
已经有6人回复
-
304求调剂
已经有5人回复
-
317一志愿华南理工电气工程求调剂
已经有8人回复
-
272求调剂
已经有3人回复
-
化工专硕348，一志愿985求调剂
已经有6人回复
-
292求调剂
已经有3人回复
-
290求调剂
已经有6人回复
-
295求调剂
已经有5人回复
» 抢金币啦！回帖就可以得到:
-
江西景德镇某大学接受调剂：环境科学与工程专业
+1/180
-
长春工业大学化学工程学院招收26年硕士调剂生
+1/80
-
设备故障诊断与预测性维护方向-硕博研究生兼职
+1/37
-
同济大学环境学院 肖倩课题组 硕士招生
+1/37
-
哈工大 化工学院招26级博士生（钙钛矿太阳能电池/传感器方向）
+1/33
-
澳门理工大学人工智能智慧康养26 年9月入学 博士招生有奖学金
+1/32
-
南通大学生物医药方向国家级人才团队招收“申请-考核”制博士研究生20260222
+2/26
-
“教育部长江学者和创新团队发展计划”入选团队招收材料，化学与化工博士研究生
+1/13
-
2026年接收考研调剂生
+1/9
-
长江大学农学院硕士生招生
+1/9
-
邀稿综述，作者排名和工作量分工问题，存在不满和疑问。
+1/6
-
26届计算机、电子信息类、电科、控制、通信考研T j信息pp骏：74+08+76+6+20>
+1/5
-
中国石油大学（华东）生物质绿色化学转化和生物基功能高分子团队诚招26级硕士生
+1/3
-
深圳大学何传新课题组诚聘“百人计划”（副）教授、助理教授
+1/3
-
英国南安普顿大学招博后+博士（微流控，分子动力学）
+1/1
-
攀钢研究院2026年招聘（央企，钒钛国家重点实验室）
+1/1
-
【博士招生】广西大学招收电化学方向审核制博士研究生
+1/1
-
大连理工大学 蒋孟男课题组（国家级高层次青年人才）诚招博士后/科研助理
+1/1
-
26届计算机、电子信息类、电科、控制、通信考研T j信息pp骏：74+08+76+6+20
+1/1
-
26届计算机、电子信息类、电科、控制、通信考研T j信息pp骏：74+08+76+6+20》
+1/1
5楼2022-09-19 15:51:10
6楼2022-09-19 18:55:41
9楼2022-09-21 16:29:44
10楼2022-09-21 21:51:59
12楼2022-10-16 22:12:16
16楼2022-11-17 12:19:03
18楼2023-01-07 11:31:09
19楼2023-01-13 20:50:07
20楼2023-01-16 08:13:30
简单回复
tzynew2楼
2022-09-19 11:36
回复
Strawberrix(金币+1): 谢谢参与
2022-09-19 11:41
回复
Strawberrix(金币+1): 谢谢参与
XG-WUST4楼
2022-09-19 12:54
回复
Strawberrix(金币+1): 谢谢参与
up 发自小木虫IOS客户端
kingluck7楼
2022-09-19 23:21
回复
Strawberrix(金币+1): 谢谢参与
2022-09-20 09:05
回复
Strawberrix(金币+1): 谢谢参与
假大空11楼
2022-09-25 17:46
回复
Strawberrix(金币+1): 谢谢参与
顶
Strawberrix13楼
2022-11-03 11:57
回复
顶一下
Strawberrix14楼
2022-11-15 10:53
回复
顶
China202215楼
2022-11-15 10:57
回复
Strawberrix(金币+1): 谢谢参与
Strawberrix17楼
2022-11-21 21:17
回复
Up~
