| 查看: 1565 | 回复: 19 | |||
| 【有奖交流】积极回复本帖子，参与交流，就有机会分得作者 Strawberrix 的 1 个金币 ，回帖就立即获得 1 个金币，每人有 1 次机会 | |||
[交流]
系统生物学读博全奖，CSC-University Maastricht 项目 2
|
|||
|
和csc的项目。感兴趣者请将英文版cv和transcript发送至 Prof. Dr. Renaud Jolivet (r.jolivet@maastrichtuniversity.nl) 或 dr. marian breuer （marian.breuer@maastrichtuniversity.nl） 并向他直接咨询其他信息。 Project title: Modeling the Metabolic Diversity of the Brain’s Glial Cells Project leader: Prof. Dr. Renaud Jolivet, Dr. Marian Breuer Function: Professor of Neural Engineering and Computation Collaborators: Prof. Dr. Ilja Arts Proposal (250 words): Introduction: The brain consists of a variety of cell types, and neurons only constitute around half of the brain cell population. The other cell populations, collectively known as glial cells, support and interact with neurons in various ways. Glial cells play a pivotal role in normal brain function as well as neurodegenerative and other disorders, and thus their understanding is of importance in the context of public health. However, while glial cells are known to play an important role in brain metabolism overall, their particular metabolic functions and interactions are far from understood. Hypothesis and Objectives: This project will study the metabolic functions of different types of glial cells, as well as their metabolic interactions, and how these are affected in aging and different pathological conditions. Setting and Methods: The project will make use of large publicly available neuroscience transcriptome data sets to build models of the metabolic network of various types of glial cells, and to study how these glial cells interact with each other in the brain. The project will then make use of other transcriptomes to investigate these interactions in aging and in various diseases of the central nervous system. Impact: The metabolic functions and interactions of glial cells in normal brain function address an important knowledge gap in basic neuroscience; while their perturbations in aging, neurodegenerative diseases and other pathological conditions could help to elucidate disease mechanisms as well as suggest potential intervention strategies – with strong potential impact in healthy aging and disease diagnosis and therapy. Requirements candidate: Highly motivated student with good English communication skills and proactive and resolute attitude. The project requires good programming skills and an interest for the complexity and diversity of the brain’s heterocellular population. The ideal candidate would have a foundation in biochemistry and cellular metabolism on the one hand, and some computational skills on the other hand, preferably in Matlab. Applications with background in only the biochemical or computational side are still welcome, if the applicant can make a case for being able to catch up in the other aspect. Keywords: Biological Foundations of Human Health and Diseases, Computational Biology, Systems Biology, Metabolic Modeling, Neuroscience, Aging Top 5 selected publications: 1. Cullen CL, Pepper RE, Clutterbuck MT, Pitman KA, Oorschot V, Auderset L, Tang AD, Ramm G, Emery B, Rodger J, Jolivet RB & Young KM “Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain” Cell Rep. (2021), 34:108641. Citations (Web of Science): 7 2. Caruso G, Caraci F & Jolivet RB “Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders” Progress in Neurobiol. (2019), 175:35. Citations (Web of Science): 29 3. Madry C*, Kyrargyri V*, Arancibia-Cárcamo IL*, Jolivet RB*, Kohsaka S, Bryan RM & Attwell D “Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1” Neuron (2018), 97:299. Citations (Web of Science): 146, top 1% cited in Neuroscience & Behaviour 4. M. Breuer, T. M. Earnest, C. Merryman, K. S. Wise, L. Sun, M. R. Lynott, C. A. Hutchison III, H. O. Smith, J. D. Lapek Jr., D. J. Gonzalez, V. de Crécy-Lagard, D. Haas, A. D. Hanson, P. Labhsetwar, J. I. Glass, Z. Luthey-Schulten “Essential Metabolism for a Minimal Cell” eLife (2019), 8:e36842. Citations (Web of Science): 37 5. C. Sarathy, M. Breuer, M. Kutmon, M. E. Adriaens, C. T. Evelo, I. C. W. Arts “Comparison of metabolic states using genome-scale metabolic models” PLOS Comp. Biol. (2021), 17:e1009522. Additional details - Duration: Four years - No mandatory course work - English: Good score on TOEFL, IELTS or other test beneficial, but English language skills will be gauged primarily during personal interview - Cooperative program - Maastricht University has limited number of reserved spots; beyond these, application through general program possible - Further information: - www.maastrichtuniversity.nl/um-china-team#um-csc - www.maastrichtuniversity.nl/phd-project-outlines - Contact details: - Dr. Marian Breuer: marian.breuer@maastrichtuniversity.nl - Prof. Dr. Renaud Jolivet: r.jolivet@maastrichtuniversity.nl |
回复此楼» 猜你喜欢
085600 材料与化工 295 求调剂
已经有9人回复
-
工科0856专硕化学工程269能调剂吗
已经有3人回复
-
288求调剂
已经有17人回复
-
312求调剂
已经有3人回复
-
调剂
已经有5人回复
-
材料工程307，求调剂
已经有6人回复
-
调剂
已经有5人回复
-
086000生物与医药319分求调剂
已经有8人回复
-
材料与化工（0856）304求B区调剂
已经有7人回复
-
313求调剂
已经有3人回复
» 抢金币啦！回帖就可以得到:
-
上海优秀男生诚征结婚女友符合微信联系
+3/781
-
福建农林大学材料工程学院-黄彪教授课题组招收调剂硕士研究生
+3/658
-
海南大学肖永昊老师团队招收2026年博士研究生（第二批）
+5/400
-
西北大学化材院张健健教授课题组招收2026“化生-探针”博士研究生1名
+2/132
-
2026年西华大学材料学院-材料近净成形与表面技术研究团队-招收研究生
+1/85
-
2026年植物保护学/农业昆虫与害虫防治/农药学/植物病理学相关专业招收硕士研究生
+1/69
-
广西师范大学化学与药学学院杨秀林课题组2026年拟招收博士研究生1名
+2/50
-
中南大学粉末冶金研究院招收2026年博士研究生
+1/36
-
中科院化学所 宋延林 课题组招聘合成化学方向博士后（开展打印合成化学方向研究）
+1/35
-
深圳理工大学梁国进课题组（成会明院士团队）诚聘科研助理教授、博士后
+1/32
-
美国密苏里大学“柔性电子”课题组诚聘博士和博士后
+1/26
-
接收2026调剂研究生
+1/18
-
中国科学院苏州纳米所院士团队博士后岗位招聘
+1/16
-
重庆大学药学院闫海龙课题组拟招收2026年申请考核制博士研究生数名
+1/13
-
海南大学徐月山老师招生2026年第二批博士名额2~3个（高端设备开发方向）
+1/8
-
重庆大学药学院闫海龙课题组拟招收2026年申请考核制博士研究生
+1/8
-
天津大学浙江研究院（宁波）诚聘高分子/化学/材料方向博士后、青年特聘研究员
+1/6
-
地理学数二英一316求调剂
+1/4
-
2026年东北石油大学“页岩油气钻采高效井眼清洁”创新团队招硕士生
+1/4
-
有青基找工作是优势还是劣势？
+1/3
5楼2022-09-19 15:51:10
6楼2022-09-19 18:55:41
9楼2022-09-21 16:29:44
10楼2022-09-21 21:51:59
12楼2022-10-16 22:12:16
16楼2022-11-17 12:19:03
18楼2023-01-07 11:31:09
19楼2023-01-13 20:50:07
20楼2023-01-16 08:13:30
简单回复
tzynew2楼
2022-09-19 11:36
回复
Strawberrix(金币+1): 谢谢参与
2022-09-19 11:41
回复
Strawberrix(金币+1): 谢谢参与
XG-WUST4楼
2022-09-19 12:54
回复
Strawberrix(金币+1): 谢谢参与
up 发自小木虫IOS客户端
kingluck7楼
2022-09-19 23:21
回复
Strawberrix(金币+1): 谢谢参与
2022-09-20 09:05
回复
Strawberrix(金币+1): 谢谢参与
假大空11楼
2022-09-25 17:46
回复
Strawberrix(金币+1): 谢谢参与
顶
Strawberrix13楼
2022-11-03 11:57
回复
顶一下
Strawberrix14楼
2022-11-15 10:53
回复
顶
China202215楼
2022-11-15 10:57
回复
Strawberrix(金币+1): 谢谢参与
Strawberrix17楼
2022-11-21 21:17
回复
Up~
