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虫号: 26697155

[交流] Hackensack Meridian School of Medicine（新泽西州）张毅实验室招聘三名博士后

Three postdoctoral positions are available in Dr. Yi Zhang’s lab at Center for Discovery & Innovation, Hackensack Meridian School of Medicine (New Jersey). Dr. Zhang introduced for the first time the concept of alloantigen-sensitized stem cell memory T cells in sustaining alloimmunity. This concept of T cell stemness stimulates cancer immunotherapy field to develop novel strategies for improving the efficacy of cancer therapy. The Zhang lab has also discovered that Ezh2 plays multiple roles in the regulation of T cell stemness and T cell immunity.

Currently, the Zhang lab studies epigenetic therapy, focusing on immune regulation and tumor immune-sensitization. Ongoing research projects investigate: 1) the molecular pathways that mediate Ezh2 actions in T cells; 2) epigenetic therapy to sensitize tumor to T cell immunity; and 3) novel genetic and pharmacologic approaches to program T cells for improving the efficacy of cancer immunotherapy. Advanced technologies, including drug-screening, CRISPR-editing and scRNA-sequencing analysis, are leveraged to facilitate these studies.

The ideal candidate should have PhD degree or equivalent, with at least one 1st author publication. Background in immunology, cancer biology and molecular genetics is preferred. The candidate should be highly motivated and able to work independently under the PI’s supervision, with strong scientific ethnic. Please submit application electronically with CV, statement of interest and the names/ emails of three referees to: Dr. Yi Zhang (Professor), Email: yi.zhang@temple.edu.

Hackensack Meridian School of Medicine（新泽西州）发现与创新中心的 Yi Zhang 博士实验室提供三个博士后职位。张博士首次创立了干细胞样记忆T细胞维持同种异体抗原免疫反应的概念。这一概念引导了癌症免疫治疗领域开发提高癌症治疗功效的新策略。张实验室还发现Ezh2在调节T细胞干性和T细胞免疫中发挥多重作用。

目前，张实验室研究表观遗传疗法，重点是免疫调节和肿瘤免疫致敏。正在进行的项目研究：1) 在 T 细胞中介导 Ezh2 作用的分子途径； 2) 表观遗传疗法增强肿瘤对 T 细胞免疫敏感； 3) 新的遗传和药理学方法编程 T 细胞以提高癌症免疫治疗的功效。多项先进的技术，包括药物筛选、CRISPR 编辑和 scRNA 测序分析，被用于促进这些研究。

理想的候选人应具有博士学位或同等学历，至少有一篇第一作者发表。有免疫学、癌症生物学和分子遗传学背景者优先。候选人应具有高度的积极性，能够在PI的指导下独立工作，具有强烈的科学素养。请将申请电子版连同简历、意向书和三位推荐人的姓名/电子邮件提交至：张毅博士，电子邮件：yi.zhang@temple.edu。

张毅教授的个人简介网址：https://medicine.temple.edu/yi-zhang
(今年9月份正式搬去Hackensack Meridian School of Medicine，新实验室的网页尚未准备好）

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