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[½»Á÷] Hackensack Meridian School of Medicine£¨ÐÂÔóÎ÷ÖÝ£©ÕÅÒãʵÑéÊÒÕÐÆ¸ÈýÃû²©Ê¿ºó

Three postdoctoral positions are available in Dr. Yi Zhang¡¯s lab at Center for Discovery & Innovation, Hackensack Meridian School of Medicine (New Jersey). Dr. Zhang introduced for the first time the concept of alloantigen-sensitized stem cell memory T cells in sustaining alloimmunity. This concept of T cell stemness stimulates cancer immunotherapy field to develop novel strategies for improving the efficacy of cancer therapy. The Zhang lab has also discovered that Ezh2 plays multiple roles in the regulation of T cell stemness and T cell immunity.

Currently, the Zhang lab studies epigenetic therapy, focusing on immune regulation and tumor immune-sensitization. Ongoing research projects investigate: 1) the molecular pathways that mediate Ezh2 actions in T cells; 2) epigenetic therapy to sensitize tumor to T cell immunity; and 3) novel genetic and pharmacologic approaches to program T cells for improving the efficacy of cancer immunotherapy. Advanced technologies, including drug-screening, CRISPR-editing and scRNA-sequencing analysis, are leveraged to facilitate these studies.

The ideal candidate should have PhD degree or equivalent, with at least one 1st author publication. Background in immunology, cancer biology and molecular genetics is preferred. The candidate should be highly motivated and able to work independently under the PI¡¯s supervision, with strong scientific ethnic. Please submit application electronically with CV, statement of interest and the names/ emails of three referees to: Dr. Yi Zhang (Professor), Email: yi.zhang@temple.edu.


Hackensack Meridian School of Medicine£¨ÐÂÔóÎ÷ÖÝ£©·¢ÏÖÓë´´ÐÂÖÐÐÄµÄ Yi Zhang ²©Ê¿ÊµÑéÊÒÌṩÈý¸ö²©Ê¿ºóְλ¡£ÕŲ©Ê¿Ê״δ´Á¢Á˸Éϸ°ûÑù¼ÇÒäTϸ°ûά³ÖͬÖÖÒìÌ忹ԭÃâÒß·´Ó¦µÄ¸ÅÄî¡£ÕâÒ»¸ÅÄîÒýµ¼Á˰©Ö¢ÃâÒßÖÎÁÆÁìÓò¿ª·¢Ìá¸ß°©Ö¢ÖÎÁƹ¦Ð§µÄвßÂÔ¡£ÕÅʵÑéÊÒ»¹·¢ÏÖEzh2ÔÚµ÷½ÚTϸ°û¸ÉÐÔºÍTϸ°ûÃâÒßÖз¢»Ó¶àÖØ×÷Óá£

Ŀǰ£¬ÕÅʵÑéÊÒÑо¿±í¹ÛÒÅ´«ÁÆ·¨£¬ÖصãÊÇÃâÒßµ÷½ÚºÍÖ×ÁöÃâÒßÖÂÃô¡£ÕýÔÚ½øÐеÄÏîÄ¿Ñо¿£º1) ÔÚ T ϸ°ûÖн鵼 Ezh2 ×÷ÓõķÖ×Ó;¾¶£» 2) ±í¹ÛÒÅ´«ÁÆ·¨ÔöÇ¿Ö×Áö¶Ô T ϸ°ûÃâÒßÃô¸Ð£» 3) еÄÒÅ´«ºÍÒ©Àíѧ·½·¨±à³Ì T ϸ°ûÒÔÌá¸ß°©Ö¢ÃâÒßÖÎÁƵĹ¦Ð§¡£¶àÏîÏȽøµÄ¼¼Êõ£¬°üÀ¨Ò©Îïɸѡ¡¢CRISPR ±à¼­ºÍ scRNA ²âÐò·ÖÎö£¬±»ÓÃÓÚ´Ù½øÕâЩÑо¿¡£

ÀíÏëµÄºòÑ¡ÈËÓ¦¾ßÓв©Ê¿Ñ§Î»»òͬµÈѧÀú£¬ÖÁÉÙÓÐһƪµÚÒ»×÷Õß·¢±í¡£ÓÐÃâÒßѧ¡¢°©Ö¢ÉúÎïѧºÍ·Ö×ÓÒÅ´«Ñ§±³¾°ÕßÓÅÏÈ¡£ºòÑ¡ÈËÓ¦¾ßÓи߶ȵĻý¼«ÐÔ£¬Äܹ»ÔÚPIµÄÖ¸µ¼Ï¶ÀÁ¢¹¤×÷£¬¾ßÓÐÇ¿ÁҵĿÆÑ§ËØÑø¡£Ç뽫ÉêÇëµç×Ó°æÁ¬Í¬¼òÀú¡¢ÒâÏòÊéºÍÈýÎ»ÍÆ¼öÈ˵ÄÐÕÃû/µç×ÓÓʼþÌá½»ÖÁ£ºÕÅÒ㲩ʿ£¬µç×ÓÓʼþ£ºyi.zhang@temple.edu¡£

ÕÅÒã½ÌÊڵĸöÈ˼ò½éÍøÖ·£ºhttps://medicine.temple.edu/yi-zhang
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