| 查看: 874 | 回复: 16 | |||
| 【有奖交流】积极回复本帖子，参与交流，就有机会分得作者 wiggins_92 的 7 个金币 ，回帖就立即获得 1 个金币，每人有 1 次机会 | |||
[交流]
英国萨里大学全奖博士：结合光谱成像和计算建模来评估皮肤渗透性
|
|||
|
Supervisor: Dr Tao Chen, Chemical and Process Engineering, University of Surrey Personal website: https://www.surrey.ac.uk/people/tao-chen Note: This studentship is open to oversea candidates. Please read through the detailed description and guidance below. Research focus: Integrated spectroscopic imaging and computational modelling approach for assessing skin penetration Project Description Skin penetration underpins the design, efficacy and risk assessment of many high-value products including topical and transdermal drugs, functional personal care products, amongst others. Given the ethical concerns with animal tests, this area is moving towards ex vivo / in vitro experimental studies using excised human skin samples. Nevertheless, current in vitro tests have limited capability in predicting in vivo results. To this end, computer (in silico) modelling has been recognised as a promising approach for in vitro – in vivo extrapolation. However, existing models have limited accuracy due to paucity of reliable and quantitative information concerning penetration pathways and penetrant distribution at the site of action in the skin. In addition, in vivo animal studies are still widespread in the pre-clinical stage of drug development. In silico models, if sufficiently accurate, have great promise to help optimise such experiments with potentially substantial reduction of animal use. To address this challenge, we propose to apply advanced spectroscopic imaging, stimulated Raman scattering (SRS) microscopy, to in vitro assessment of skin penetration. SRS microscopy provides quantitative images with submicron spatial resolution. For the first time, direct measurement of penetration pathways and microscopic distribution of the chemical in the skin will be obtained, which we will use to improve existing in silico models. The integrated modelling-imaging toolkit will significantly improve the in vitro – in vivo extrapolation capability, delivering a more systematic approach for skin penetration assessment. Importantly, the toolkit will help better design and reduce in vivo animal experiments that cannot be completely replaced at present. This studentship is open to all academically qualified candidates with no residence restrictions. The studentship will last for three years. It will cover the tuition fee and provide a PhD stipend at the standard UK Research Council rate (currently at about £15,000 per annum), as well as generous budget for training activities (workshops, conferences, etc.) -- training will provided to the successful candidate for this multi-disciplinary project. The student will be jointly supervised by Dr Tao Chen at University of Surrey and Dr Natalie Belsey at National Physical Laboratory. Entry requirements: A relevant degree (first or upper second) in engineering, physics, chemistry or mathematics. Experience in, or capability to learn, experimental methods using spectroscopy and computer modelling. A Master’s degree is not a pre-requisite but would be looked upon favourably. Non-native speakers of English who did not study in an English speaking country will be required to have IELTS 6.5 or above. How to apply: Students should apply through the Chemical and Process Engineering Research PhD programme: https://www.surrey.ac.uk/postgra ... eering-research-phd The application shall include: Cover letter (max 1 page) explaining your interest and suitability for the project. CV (max 2 pages). Published work such as journals and conference articles (if any). Copy of your academic transcripts. Copy of your MSc dissertation (if appropriate). Names and contact information of two referees. If applicable, a copy of a valid IELTS certificate from the past two years. Any enquiries should be emailed to Dr Tao Chen. Shortlisted candidates will be interviewed in early March. PLEASE NOTE: This studentship will commence on the 1st October 2020 but also has the opportunity to start in July 2020. Funding Notes The studentship will last for 3 years. It will cover the tuition fee in full, and provide a PhD stipend at the standard UKRI level (c. £15,000 per annum), as well as generous budget for training activities (workshops, conferences, etc.). |
回复此楼» 猜你喜欢
322求调剂
已经有0人回复
-
302分求调剂
已经有0人回复
-
半导体科学与信息器件论文润色/翻译怎么收费?
已经有97人回复
-
天津理工大学-新能源研究院-国家海外优青韩久慧教授招收调剂研究生-材料专业
已经有0人回复
-
请教：有个 Take Action 按钮，里面有“view to withdraw article"
已经有4人回复
-
钠电层状锰基氧化物掺Ti取代Mn如何通过XRD确定成功取代
已经有2人回复
-
本科985，一志愿中科院电子信息，312分求调剂
已经有0人回复
-
银纳米线
已经有1人回复
-
東京大学 应用化学专业柳田研究室 招收研究生
已经有0人回复
-
博士申请
已经有26人回复
-
山东大学集成电路学院夏令营保研招生（微电子器件方向-2025年9月入学）
已经有15人回复
» 抢金币啦！回帖就可以得到:
-
诚征男友非诚勿扰
+1/122
-
诚征女友非诚勿扰坐标郑州
+1/110
-
海南大学化学化工学院招收2024年博士
+1/81
-
中国科学院过程工程研究所 介科学与工程全国重点实验室课题组 招收联合培养硕士若干名
+5/39
-
招聘高校学院秘书
+1/36
-
求助BT-474人乳腺导管癌细胞
+1/30
-
山东大学陈皓课题组诚聘有机合成方向科研助理
+1/28
-
B07化学生物学送审了吗
+1/27
-
浙大博后招聘、访学招聘---课题方向不限
+1/27
-
【香港城市大学】范战西教授课题组招收博士研究生（2025秋，全奖）
+1/24
-
瑞典林雪平大学 Magnus 组招偏光学背景的博士 雇佣待遇 欢迎申请！
+2/20
-
2024 Fall-美国University of Louisville招聘全奖博士生
+1/20
-
求推荐动力工程及工程热物理读博团队及导师
+1/13
-
中科院地理所客座研究生招聘
+1/8
-
两年超100万！温医大谢聪颖教授/同济大学胡勇教授联合培养“医工交叉”博士后
+1/6
-
路易斯安那大学拉法叶分校土木工程招全奖博士和硕士
+1/5
-
打算组个电化学的讨论群，有想来的友友吗？
+1/3
-
关于电解液中溶剂化作用或者氢键相互作用对羧酸盐红外峰的偏移
+1/2
-
干货分享 | 淋巴细胞和NK细胞，是如何生成的？
+1/1
-
西安交通大学物理学院高国平课题组 招收2025级硕士、博士
+1/1
+1/122
3楼2020-01-28 00:07:54
4楼2020-01-28 10:20:50
简单回复
tzynew2楼
2020-01-27 23:58
回复
wiggins_92(金币+1): 谢谢参与
8 发自小木虫Android客户端
dsctg5楼
2020-01-28 11:05
回复
wiggins_92(金币+1): 谢谢参与
一 发自小木虫Android客户端
2020-01-28 11:55
回复
wiggins_92(金币+1): 谢谢参与
m_inter7楼
2020-01-29 14:26
回复
wiggins_92(金币+1): 谢谢参与
sct738楼
2020-01-29 17:38
回复
wiggins_92(金币+1): 谢谢参与
如尹9楼
2020-01-29 17:57
回复
wiggins_92(金币+1): 谢谢参与
1 发自小木虫IOS客户端
guanlianwu10楼
2020-01-29 18:13
回复
wiggins_92(金币+1): 谢谢参与
psylhh11楼
2020-01-29 22:32
回复
wiggins_92(金币+1): 谢谢参与
小___小12楼
2020-01-30 00:00
回复
wiggins_92(金币+1): 谢谢参与
。 发自小木虫Android客户端
nono200913楼
2020-01-30 10:32
回复
wiggins_92(金币+1): 谢谢参与
·
shenrenren14楼
2020-01-30 10:42
回复
wiggins_92(金币+1): 谢谢参与
阿尔8萨斯15楼
2020-02-02 16:32
回复
wiggins_92(金币+1): 谢谢参与
shenrenren16楼
2020-02-02 21:53
回复
阿尔8萨斯17楼
2020-02-02 22:58
回复
