| 查看: 881 | 回复: 16 | |||
| 【有奖交流】积极回复本帖子，参与交流，就有机会分得作者 wiggins_92 的 7 个金币 ，回帖就立即获得 1 个金币，每人有 1 次机会 | |||
[交流]
英国萨里大学全奖博士：结合光谱成像和计算建模来评估皮肤渗透性
|
|||
|
Supervisor: Dr Tao Chen, Chemical and Process Engineering, University of Surrey Personal website: https://www.surrey.ac.uk/people/tao-chen Note: This studentship is open to oversea candidates. Please read through the detailed description and guidance below. Research focus: Integrated spectroscopic imaging and computational modelling approach for assessing skin penetration Project Description Skin penetration underpins the design, efficacy and risk assessment of many high-value products including topical and transdermal drugs, functional personal care products, amongst others. Given the ethical concerns with animal tests, this area is moving towards ex vivo / in vitro experimental studies using excised human skin samples. Nevertheless, current in vitro tests have limited capability in predicting in vivo results. To this end, computer (in silico) modelling has been recognised as a promising approach for in vitro – in vivo extrapolation. However, existing models have limited accuracy due to paucity of reliable and quantitative information concerning penetration pathways and penetrant distribution at the site of action in the skin. In addition, in vivo animal studies are still widespread in the pre-clinical stage of drug development. In silico models, if sufficiently accurate, have great promise to help optimise such experiments with potentially substantial reduction of animal use. To address this challenge, we propose to apply advanced spectroscopic imaging, stimulated Raman scattering (SRS) microscopy, to in vitro assessment of skin penetration. SRS microscopy provides quantitative images with submicron spatial resolution. For the first time, direct measurement of penetration pathways and microscopic distribution of the chemical in the skin will be obtained, which we will use to improve existing in silico models. The integrated modelling-imaging toolkit will significantly improve the in vitro – in vivo extrapolation capability, delivering a more systematic approach for skin penetration assessment. Importantly, the toolkit will help better design and reduce in vivo animal experiments that cannot be completely replaced at present. This studentship is open to all academically qualified candidates with no residence restrictions. The studentship will last for three years. It will cover the tuition fee and provide a PhD stipend at the standard UK Research Council rate (currently at about £15,000 per annum), as well as generous budget for training activities (workshops, conferences, etc.) -- training will provided to the successful candidate for this multi-disciplinary project. The student will be jointly supervised by Dr Tao Chen at University of Surrey and Dr Natalie Belsey at National Physical Laboratory. Entry requirements: A relevant degree (first or upper second) in engineering, physics, chemistry or mathematics. Experience in, or capability to learn, experimental methods using spectroscopy and computer modelling. A Master’s degree is not a pre-requisite but would be looked upon favourably. Non-native speakers of English who did not study in an English speaking country will be required to have IELTS 6.5 or above. How to apply: Students should apply through the Chemical and Process Engineering Research PhD programme: https://www.surrey.ac.uk/postgra ... eering-research-phd The application shall include: Cover letter (max 1 page) explaining your interest and suitability for the project. CV (max 2 pages). Published work such as journals and conference articles (if any). Copy of your academic transcripts. Copy of your MSc dissertation (if appropriate). Names and contact information of two referees. If applicable, a copy of a valid IELTS certificate from the past two years. Any enquiries should be emailed to Dr Tao Chen. Shortlisted candidates will be interviewed in early March. PLEASE NOTE: This studentship will commence on the 1st October 2020 but also has the opportunity to start in July 2020. Funding Notes The studentship will last for 3 years. It will cover the tuition fee in full, and provide a PhD stipend at the standard UKRI level (c. £15,000 per annum), as well as generous budget for training activities (workshops, conferences, etc.). |
回复此楼» 猜你喜欢
322求调剂
已经有0人回复
-
302分求调剂
已经有0人回复
-
半导体科学与信息器件论文润色/翻译怎么收费?
已经有124人回复
-
天津理工大学-新能源研究院-国家海外优青韩久慧教授招收调剂研究生-材料专业
已经有0人回复
-
请教：有个 Take Action 按钮，里面有“view to withdraw article"
已经有4人回复
-
钠电层状锰基氧化物掺Ti取代Mn如何通过XRD确定成功取代
已经有2人回复
-
本科985，一志愿中科院电子信息，312分求调剂
已经有0人回复
-
银纳米线
已经有1人回复
-
東京大学 应用化学专业柳田研究室 招收研究生
已经有0人回复
-
博士申请
已经有28人回复
-
山东大学集成电路学院夏令营保研招生（微电子器件方向-2025年9月入学）
已经有15人回复
» 抢金币啦！回帖就可以得到:
-
CEJ投稿祈福
+5/200
-
避坑- 北京清析技术研究院 - 一个典型的坑人检测机构
+1/86
-
山东科技大学生物地球环境化学团队博士后招聘
+1/80
-
**待遇优厚**大湾区大学（筹）苏强课题组【诚聘量子点发光器件方向博士后、特任研究员
+2/62
-
Postdoctoral Position @ HK CityU Prof. Zheng' s team. 港城大郑星课题组招聘1～2名
+1/44
-
中国海洋大学固体发光与应力传感方向招聘青年英才
+2/38
-
免费提供创业场地，坐标海淀区学院南路
+1/38
-
西湖大学工学院李秋珵实验室科研助理招聘启事
+1/36
-
中国科学院福建物质结构研究所招聘博后和副研究员
+1/36
-
中科院上海光源科学中心招收联培研究生
+1/31
-
海南大学田新龙团队，诚聘海洋化学方向青年教授和博士后！
+1/29
-
同济大学柔性电子与生物传感课题组招生招聘（分析化学、微纳加工等方向）
+1/23
-
北京大学深圳研究生院 翟宏斌课题组诚聘科研助理（有机化学）
+1/7
-
25博士申请，找博导
+1/7
-
中国农业大学机械电子工程学科招聘博士后
+1/6
-
五邑大学材料与化工专业研究生求职
+1/5
-
深圳大学吴奇院士/李连伟教授团队高分子与食品科学博士后招聘
+1/4
-
铀酰离子处理后的dnazyme（DNA核酶）没有现象
+1/4
-
诚征女友，坐标南宁（邕城）
+4/4
-
北京理工大学与深圳儿童医院诚招科研助理（纳米抗体方向）
+1/1
+5/200
3楼2020-01-28 00:07:54
4楼2020-01-28 10:20:50
简单回复
tzynew2楼
2020-01-27 23:58
回复
wiggins_92(金币+1): 谢谢参与
8 发自小木虫Android客户端
dsctg5楼
2020-01-28 11:05
回复
wiggins_92(金币+1): 谢谢参与
一 发自小木虫Android客户端
2020-01-28 11:55
回复
wiggins_92(金币+1): 谢谢参与
m_inter7楼
2020-01-29 14:26
回复
wiggins_92(金币+1): 谢谢参与
sct738楼
2020-01-29 17:38
回复
wiggins_92(金币+1): 谢谢参与
如尹9楼
2020-01-29 17:57
回复
wiggins_92(金币+1): 谢谢参与
1 发自小木虫IOS客户端
guanlianwu10楼
2020-01-29 18:13
回复
wiggins_92(金币+1): 谢谢参与
psylhh11楼
2020-01-29 22:32
回复
wiggins_92(金币+1): 谢谢参与
小___小12楼
2020-01-30 00:00
回复
wiggins_92(金币+1): 谢谢参与
。 发自小木虫Android客户端
nono200913楼
2020-01-30 10:32
回复
wiggins_92(金币+1): 谢谢参与
·
shenrenren14楼
2020-01-30 10:42
回复
wiggins_92(金币+1): 谢谢参与
阿尔8萨斯15楼
2020-02-02 16:32
回复
wiggins_92(金币+1): 谢谢参与
shenrenren16楼
2020-02-02 21:53
回复
阿尔8萨斯17楼
2020-02-02 22:58
回复
