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华西梧桐树

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[交流] 哥本哈根大学药剂学专业多肽蛋白传递方向博士招聘

http://employment.ku.dk/phd/?show=853174

PhD fellowship in peptide and protein delivery

Department of Pharmacy
Faculty of Health and Medical Sciences (SUND)
University of Copenhagen

Department of Pharmacy is offering a three-year PhD fellowship within the field of biopharmaceuticals and biophysics. The PhD fellowship is financed by the University of Copenhagen. The fellowship is available from 1 December 2016 or as soon as possible thereafter.

Project description
As a consequence of rapidly increasing resistance development in bacteria against conventional antibiotics, the interest for alternative therapeutics has increased. Antimicrobial peptides constitute one such class of potential therapeutics. In our earlier work, we have identified a battery of endogenous peptides displaying potent antimicrobial effects but simultaneously low toxicity against human cells. Some of these peptides also display potent anti-inflammatory effects, of considerable interest in both acute and chronic inflammation, as well as anti-cancer effects. However, efficient therapies based on such peptides, as well as other biomacromolecular drugs, also require efficient delivery systems, as such drugs are susceptible to both chemical and enzymatic degradation, and prone to conformational changes and/or aggregation, with pronounced consequences for functionality and safety.
The project aims at building new knowledge on peptide interactions with polymer-based microgels, and the use of the latter as peptide delivery systems, building on our previous work on factors affecting peptide and protein loading to, distribution within, and release from microgels, as well as biodegradation effects. In particular, focus in the project will be placed on employing physicochemical methodology for studies of effects on microgel properties (charge, size, cross-linking density, degradability) on their use as delivery systems for antimicrobial and related peptides, both in solution and at surfaces, the latter of interest for localized depot therapies and functional biomaterials. The work is performed using advanced biophysical methods, such as neutron scattering, ellipsometry/QCM, and confocal microscopy. Biophysical results are correlated to biological studies of cell uptake and toxicity, in collaboration with research groups specialized in such studies.
Principal supervisor
Professor Martin Malmsten, Department of Pharmacy (as of 1 October 2016)
Direct phone: + 46 704250913.

Required qualifications
As an applicant you must have:
•Obtained a relevant Master′s degree prior to the starting date
•Fluency in English and excellent communication skills
•The ability to work in an interdisciplinary environment.
•The ability to travel for performing experiments abroad.

Preferred qualifications
We are looking for a highly motivated candidate with a strong background in pharmaceutics, chemical engineering, or chemistry. An orientation to physical chemistry or polymer chemistry is an advantage.

Job description
Your key tasks as a PhD fellow at the Faculty are to:
•Carry through an independent research project under supervision
•Write scientific articles and the PhD thesis on the grounds of your research project
•Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
•Obtain experience with teaching or other types of dissemination related to your PhD project
•Participate in the undergraduate teaching of students in pharmaceutical sciences
•Participate in national and international congresses and scientific meetings
•Stay at an external research institution, preferably abroad

Key criteria for the assessment of applicants
•Professional qualifications relevant to the PhD programme
•Relevant work experience
•Previous publications
•The grade point average achieved
•Other professional activities
•Language skills
•The successful applicant is also required to be enterprising and to possess good interpersonal skills

Formal requirements
The successful applicant will be requested to formally apply for enrolment as a PhD student at the Faculty of Health and Medical Sciences according to the rules stipulated in the Ministerial order on the PhD programme at the universities (PhD order) from the Ministry of Science, Innovation, and Higher Education and the guidelines for the PhD programme at the Faculty of Health and Medical Sciences.

The PhD student is expected to be affiliated to the graduate programme in pharmaceutical sciences, Drug Research Academy.

Terms of employment
The position as a PhD fellow is available for a 3-year period.

Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organizations. The position is covered by the Protocol on Job Structure.
Minimum monthly salary is DKK 25,579 (taxable) + pension contribution.

Application procedure
The application, in English, must be submitted electronically by clicking APPLY NOW below.
Your application must include:

•Cover letter: Letter stating the interest in and qualifications for the project (max. one page)
•Full CV
•Diploma and transcripts of records: Master′s degree diploma (including grade transcripts for bachelor′s and master′s degrees). Applicants with a Master′s degree from abroad should also enclose a short description of the grading scale used
•Possible publication list
•Other information to consider: Possible references and recommendations

The University of Copenhagen wishes to encourage everyone interested in this post to apply, regardless of personal background.

Deadline for applications
25 September 2016. Please note that only online applications will be accepted.
Applications received later than this date will not be considered.

Post application procedure
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee.
All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee.
Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at employment.ku.dk

The Appointments Committee consists of the supervision group and the Head of Department who is the authorized recruitment manager. The Expert Assessment Committee consists of the principal supervisor.

An answer as to the granting of the fellowship can be expected approx. 4 weeks after application deadline.

Questions
For further information, applicants may contact the supervisor or Administrator Marianne W. Jørgensen, e-mail: marianne.joergensen@sund.ku.dk, direct phone: +45 3533 6449.

For more information on working and living in Denmark visit ism.ku.dk (International staff mobility) and www.workindenmark.dk

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