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最新流出的药渡世界新药概览部分章节
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五星好评！！！好书好书-------
6楼2016-05-10 19:11:21
7楼2016-05-10 19:11:59
8楼2016-05-10 19:13:41
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Acotiamide Hydrochloride Hydrate (Acofide®  Research code: Z-338 in Zeria; YM-443 in Astellas 1 General Information ● Acotiamide is a peripheral acetylcholinesterase (AChE) inhibitor and the first-in-class drug to treat functional dyspepsia (FD) in the world, which was approved in 2013 by PMDA of Japan. ● Acotiamide was originally discovered by Zeria, and co-developed with Astellas. The drug is co-marketing in Japan. ● Acotiamide prevents the hydrolysis of acetylcholine by inhibiting peripheral AChE which results in the enhancement of impaired gastric motility and consequently the improvement of FD symptoms. ● Acotiamide is indicated for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to FD. ● Available as tablets with each containing 100 mg of acotiamide and the recommended starting dose is one tablet three times daily before meals. Key Approvals around the World* Japan (PMDA) First approval date 03/25/2013 NDA NO. 22500AMX00868000 Brand name Acofide® Indication FD Authorisation holder Zeria/Astellas * Till May 2015, it had not been approved by FDA (US), EMA (EU) and CFDA (China). Worldwide Sales Note: The sale data of Acofide® was not available. Active Ingredient Molecular formula: C21H30N4O5S·HCl·3H2O Molecular weight: 541.06 CAS No.: 185106-16-5 (acotiamide) 773092-05-0 (acotiamide hydrochloride trihydrate) Chemical name: N-{2-[bis(1-methylethyl)amino]ethyl}- 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino] thiazole-4- carboxamide monohydrochloride trihydrate Parameters of Lipinski's “Rule of 5” |
9楼2016-05-10 19:16:53
简单回复
2016-05-09 23:17
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五星好评 顶一下，感谢分享！
小北cc4楼
2016-05-10 08:32
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顶一下，感谢分享！
sypqingchun11楼
2016-05-10 23:27
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五星好评 顶一下，感谢分享！
xiaojie426412楼
2016-05-11 08:14
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五星好评 顶一下，感谢分享！
sjshvdc14楼
2016-05-11 08:21
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五星好评 顶一下，感谢分享！