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You Li, Dongwei Mao, Guoda Ma, Lili Cui, Hua Tao, Haihong Zhou, Wandong Liang, Bin Zhao,and Keshen Li

Nuclear export of VP19C is not essential for replication of herpes simplex virus type 1.

Cell Biosci. 2014; 4: 55.Published online 2014 Sep 19. doi:  10.1186/2045-3701-4-55  PMCID: PMC4190327

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dreamer2001ly: ½ð±Ò+10, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸ 2016-04-14 12:51:43
Ðľ²_ÒÀÈ»: LS-EPI+1, ¸ÐлӦÖú 2016-04-14 13:06:32
Nuclear export of VP19C is not essential for replication of herpes simplex virus type 1
×÷Õß:Li, Y (Li, You)[ 1,3 ] ; Mao, DW (Mao, Dongwei)[ 2 ] ; Ma, GD (Ma, Guoda)[ 1 ] ; Cui, LL (Cui, Lili)[ 1 ] ; Tao, H (Tao, Hua)[ 5 ] ; Zhou, HH (Zhou, Haihong)[ 5 ] ; Liang, WD (Liang, Wandong)[ 4 ] ; Zhao, B (Zhao, Bin)[ 1,5 ] ; Li, KS (Li, Keshen)[ 1 ]

Òþ²Ø ResearcherID ºÍ ORCID²é¿´ ResearcherID ºÍ ORCID ×÷Õß ResearcherID ORCID ºÅ
tao, hua   https://orcid.org/0000-0002-9506-5987


CELL AND BIOSCIENCE


¾í: 4
ÎÄÏ׺Å: 55

DOI: 10.1186/2045-3701-4-55

³ö°æÄê: SEP 19 2014

²é¿´ÆÚ¿¯ÐÅÏ¢

CELL AND BIOSCIENCE  

³ö°æÉÌ BIOMED CENTRAL LTD, 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND

ISSN: 2045-3701

Ñо¿ÁìÓò Biochemistry & Molecular Biology



ÕªÒª
Background: Herpes simplex virus (HSV) type 1 has a 152 kb double-stranded DNA genome that may encode more than 80 gene products, many of which remain uncharacterized. The HSV-1 triplex is a complex of three protein subunits, VP19C and a dimer of VP23 that is essential for capsid assembly. Previous studies have demonstrated that HSV-1 VP19C contains an atypical nuclear localization signal and a functional nuclear export signal (NES), which are both important for the nucleocytoplasmic shuttling of VP19C. However, whether the VP19C NES is required for efficient HSV-1 production is unknown.

Findings: In the present study, a VP19C NES-mutated recombinant virus was generated by using bacterial artificial chromosome recombineering technology to investigate the role of VP19C nuclear export in HSV-1 replication. Our results demonstrate that the growth curves, plaque areas, subcellular localization and viral gene expression are indistinguishable between the VP19C NES-mutated virus and the wild-type virus.

Conclusions: Our findings reported herein indicate abrogation of the nuclear export of VP19C did not affect HSV-1 replication and viral gene expression.

¹Ø¼ü´Ê
×÷Õ߹ؼü´Ê:VP19C; Nuclear export signal (NES); Bacterial artificial chromosome (BAC); Replication

KeyWords Plus:LOCALIZATION; IDENTIFICATION; SIGNALS; HSV-1

×÷ÕßÐÅÏ¢
ͨѶ×÷ÕßµØÖ·: Zhao, B (ͨѶ×÷Õß)       Affiliated Hosp, Guangdong Med Coll, Guangdong Key Lab Age Related Cardiac & Cerebral, Zhanjiang 524001, Peoples R China.


µØÖ·:        [ 1 ] Affiliated Hosp, Guangdong Med Coll, Guangdong Key Lab Age Related Cardiac & Cerebral, Zhanjiang 524001, Peoples R China
[ 2 ] Harbin Med Univ, Affiliated Hosp 4, Dept Obstet & Gynaecol, Harbin 150001, Heilongjiang, Peoples R China
  ÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ
    Harbin Medical University  
[ 3 ] Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China
  ÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ
    Chinese Academy of Sciences  
[ 4 ] Wenzhou Med Univ, Renji Coll, Wenzhou 325000, Peoples R China
  ÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ
    Wenzhou Medical University  
       [ 5 ] Affiliated Hosp, Guangdong Med Coll, Dept Neurol, Zhanjiang 524001, Peoples R China


µç×ÓÓʼþµØÖ·:zhaobine@126.com; likeshen1971@126.com

»ù½ð×ÊÖúÖÂл
»ù½ð×ÊÖú»ú¹¹ ÊÚȨºÅ
National Nature Science Foundation of China  31171219
81271213
81070878
81271214
81300929
81261120404  
²é¿´»ù½ð×ÊÖúÐÅÏ¢¹Ø±Õ»ù½ð×ÊÖúÐÅÏ¢   

This work was supported by funding from the National Nature Science Foundation of China (grant numbers 31171219, 81271213, 81070878, 81271214, 81300929 and 81261120404). We thank Dr. Frazer J. Rixon, Dr. C. Sweet, Dr. David Leib, Dr. Gregory Smith and Dr. Nikolaus Osterrieder for the generous gift of the antibodies against VP19C and VP23, the antibody against VP22, 17-37BAC, E. coli GS1783 and pEPkan-S, respectively.

³ö°æÉÌ
BIOMED CENTRAL LTD, 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND

Àà±ð / ·ÖÀà
Ñо¿·½Ïò:Biochemistry & Molecular Biology

Web of Science Àà±ð:Biochemistry & Molecular Biology

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ÎÄÏ×ÀàÐÍ:Article

ÓïÖÖ:English

Èë²ØºÅ: WOS:000343817500001

PubMed ID: 25302111

ISSN: 2045-3701

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3Â¥: Originally posted by baiyuefei at 2016-04-13 13:56:25
Nuclear export of VP19C is not essential for replication of herpes simplex virus type 1
×÷Õß:Li, Y (Li, You) ; Mao, DW (Mao, Dongwei) ; Ma, GD (Ma, Guoda) ; Cui, LL (Cui, Lili) ; Tao, H (Tao, Hua)  ...

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