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ISTP¼ìË÷ Coating PAMAM dendrimer onto PDMS microfluidic chip to resist nonspecific Biomolecules adsorption ×÷Õß:Lin, D (Lin, Dong)[ 1 ] ; Zhao, Q (Zhao, Qin)[ 2 ] ; Yan, MM (Yan, Miaomiao)[ 1 ] ; Hou, GG (Hou, Giuge)[ 1 ] ±àÕß:Kim, YH PROCEEDINGS OF THE 2015 INTERNATIONAL CONFERENCE ON ADVANCED ENGINEERING MATERIALS AND TECHNOLOGY ´ÔÊé: AER-Advances in Engineering Research ¾í: 38 Ò³: 204-208 ³ö°æÄê: 2015 »áÒéÃû³Æ »áÒé: 5th International Conference on Advanced Engineering Materials and Technology (AEMT) »áÒ鵨µã: Guangzhou, PEOPLES R CHINA »áÒéÈÕÆÚ: AUG 22-23, 2015 ÕªÒª The surface of poly(dimethylsiloxane)(PDMS) microfluidic chips were modified using polyamidoamine (PAMAM) dendrimer via physical coating. The results showed that the surface of the modified chips was coated by a dense, uniform, continuous, hydrophilicity layer of PAMAM. The hydrophilic of the chip surface was markedly improved. The contact angle of the chips modified decreased from 108.9 degrees to 46.1 degrees. Adenosine and L-lysine were separated via the modified PDMS microfluidic chips. Compared with unmodified chips, the modified chips successfully separated the two biomolecules. The separation efficiencies of adenosine and L-lysine were 7.19x10(4) Plates/m and 8.111x10(4) Plates/m respectively, and the resolutions(R-S) was 4.03. This research may provide a new and effective method to resist nonspecific adsorptionon the PDMS surface and the application of PDMS microfluidic chips in the determination of trace biomolecules. ¹Ø¼ü´Ê ×÷Õ߹ؼü´Ê AMAM dendrimer; microfluidic chip; caoting; hydrophilicity; adsorptionKeyWords Plus:SURFACE MODIFICATION ×÷ÕßÐÅÏ¢ ͨѶ×÷ÕßµØÖ·: Lin, D (ͨѶ×÷Õß) Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China. µØÖ·: [ 1 ] Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ [ 2 ] Ludong Univ, Coll Food Engn, Yantai 264025, Peoples R China µç×ÓÓʼþµØÖ·:lindong3503@163.com; candyffff@163.com; 342302878@qq.com; guigehou@163.com ³ö°æÉÌ ATLANTIS PRESS, 29 AVENUE LAVMIERE, PARIS, 75019, FRANCE Àà±ð / ·ÖÀà Ñо¿·½Ïò:Engineering; Materials Science Web of Science Àà±ð:Engineering, Multidisciplinary; Engineering, Manufacturing; Materials Science, Multidisciplinary ÎÄÏ×ÐÅÏ¢ ÎÄÏ×ÀàÐÍ roceedings PaperÓïÖÖ:English Èë²ØºÅ: WOS:000365261400041 ISBN:978-94-6252-108-7 ISSN: 2352-5401 ÆäËûÐÅÏ¢ IDS ºÅ: BD9TJ Web of Science ºËÐĺϼ¯ÖÐµÄ "ÒýÓõIJο¼ÎÄÏ×": 7 Web of Science ºËÐĺϼ¯ÖÐµÄ "±»ÒýƵ´Î": 0 |

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AMAM dendrimer; microfluidic chip; caoting; hydrophilicity; adsorption