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title£ºCoating PAMAM dendrimer onto PDMS microfluidic chip to resist nonspecific Biomolecules adsorption

»áÒ飺5th International Conference on Advanced Engineering Materials and Technology£¨(AEMT 2015)£©

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ÉϵÛÒ²·è¿ñ(lazy½õϪ´ú·¢): ½ð±Ò+5, ЭÖú½áÌû£¬¸ÐлӦÖú£¡ 2016-03-26 13:34:59
lazy½õϪ: LS-EPI+1, ¸ÐлӦÖú£¡ 2016-03-26 13:35:37
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Coating PAMAM dendrimer onto PDMS microfluidic chip to resist nonspecific Biomolecules adsorption
×÷Õß:Lin, D (Lin, Dong)[ 1 ] ; Zhao, Q (Zhao, Qin)[ 2 ] ; Yan, MM (Yan, Miaomiao)[ 1 ] ; Hou, GG (Hou, Giuge)[ 1 ]
±àÕß:Kim, YH
PROCEEDINGS OF THE 2015 INTERNATIONAL CONFERENCE ON ADVANCED ENGINEERING MATERIALS AND TECHNOLOGY
´ÔÊé: AER-Advances in Engineering Research
¾í: 38  Ò³: 204-208
³ö°æÄê: 2015
»áÒéÃû³Æ
»áÒé: 5th International Conference on Advanced Engineering Materials and Technology (AEMT)
»áÒ鵨µã: Guangzhou, PEOPLES R CHINA
»áÒéÈÕÆÚ: AUG 22-23, 2015
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The surface of poly(dimethylsiloxane)(PDMS) microfluidic chips were modified using polyamidoamine (PAMAM) dendrimer via physical coating. The results showed that the surface of the modified chips was coated by a dense, uniform, continuous, hydrophilicity layer of PAMAM. The hydrophilic of the chip surface was markedly improved. The contact angle of the chips modified decreased from 108.9 degrees to 46.1 degrees. Adenosine and L-lysine were separated via the modified PDMS microfluidic chips. Compared with unmodified chips, the modified chips successfully separated the two biomolecules. The separation efficiencies of adenosine and L-lysine were 7.19x10(4) Plates/m and 8.111x10(4) Plates/m respectively, and the resolutions(R-S) was 4.03. This research may provide a new and effective method to resist nonspecific adsorptionon the PDMS surface and the application of PDMS microfluidic chips in the determination of trace biomolecules.
¹Ø¼ü´Ê
×÷Õ߹ؼü´ÊAMAM dendrimer; microfluidic chip; caoting; hydrophilicity; adsorption
KeyWords Plus:SURFACE MODIFICATION
×÷ÕßÐÅÏ¢
ͨѶ×÷ÕßµØÖ·: Lin, D (ͨѶ×÷Õß)
              Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China.
µØÖ·:
              [ 1 ] Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ        [ 2 ] Ludong Univ, Coll Food Engn, Yantai 264025, Peoples R China
µç×ÓÓʼþµØÖ·:lindong3503@163.com; candyffff@163.com; 342302878@qq.com; guigehou@163.com
³ö°æÉÌ
ATLANTIS PRESS, 29 AVENUE LAVMIERE, PARIS, 75019, FRANCE
Àà±ð / ·ÖÀà
Ñо¿·½Ïò:Engineering; Materials Science
Web of Science Àà±ð:Engineering, Multidisciplinary; Engineering, Manufacturing; Materials Science, Multidisciplinary
ÎÄÏ×ÐÅÏ¢
ÎÄÏ×ÀàÐÍroceedings Paper
ÓïÖÖ:English
Èë²ØºÅ: WOS:000365261400041
ISBN:978-94-6252-108-7
ISSN: 2352-5401
ÆäËûÐÅÏ¢
IDS ºÅ: BD9TJ
Web of Science ºËÐĺϼ¯ÖÐµÄ "ÒýÓõIJο¼ÎÄÏ×": 7
Web of Science ºËÐĺϼ¯ÖÐµÄ "±»ÒýƵ´Î": 0
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2Â¥2016-03-23 17:02:50
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2Â¥: Originally posted by Ðľ²_ÒÀÈ» at 2016-03-23 17:02:50
ISTP¼ìË÷
Coating PAMAM dendrimer onto PDMS microfluidic chip to resist nonspecific Biomolecules adsorption
×÷Õß:Lin, D (Lin, Dong) ; Zhao, Q (Zhao, Qin) ; Yan, MM (Yan, Miaomiao) ; Hou, GG (Hou, Gi ...

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