ZhuanglinLi1,MingxueWang2,DelingYu2,WentingLuo1,JianminFang123,ChangjiangHuang1,XuejingYao4MonomethylauristatinE-conjugatedanti-EGFRantibodyinhibitsthegrowthofhumanEGFR-...

1.AI帮我快速找到相关文献?以前：我自己在PubMed上搜索，一个一个看摘要，判断是否相关?现在：我告诉AI"我要研究EGFR突变患者的预后因素"，AI自动检索相关文献，并用表格展示核心数据?...

FeiZhou,HaoyueGuo,YangXia,XiuningLe,DanielS.W.Tan,SureshS.Ramalingam&CaicunZhouThechangingtreatmentlandscapeofEGFR-mutantnon-small-celllungcancerNatureReviewsClinicalOncology...

比如你想研究“EGFR基因T790M突变与肺癌耐药的关系”，那目标就是EGFR基因的第790位碱基。怎么确定目标？通常是查文献——看看其他研究者关注哪些突变位点，或者根据疾病数据库（比如OMIM...

J.Zhang1,J.Wu2,Y.Du1,Y.Meng3,S.Xiao4,H.Zhu5,Y.Zhu6302MOPhaseIstudyofiza-bren(BL-B01D1),anEGFRxHER3bispecificantibody-drugconjugate(ADC),...

ChengWangad,XinWanga,ZhiHuanga,TianqiWanga,YongweiNiea,ShengyongYangc,RongXiangab,YanFanabDiscoveryandstructuraloptimizationofpotentepidermalgrowthfactorreceptor(EGFR)...

BaoweiJiaoDiscoveryofamolecularglueforEGFRdegradationOncogene202444,pages545–556(2025)10.1038/s41388-024-03241-8...

无xiongf,zhouyw,haoyt,weigx,chenxr,qium.combininganti-epidermalgrowthfactorreceptor(egfr)therapywithimmunotherapyinmetastaticcolorectalcancer(mcrc)....18(4-5):185-192.doi:10.1080/...

孙思凡新型抗EGFR人源化抗体基因的构建和表达安徽大学硕士学位论文20091-300DOI:10.7666/d.Y2261271https://d.wanfangdata.com.cn/thesis/Y2261271万方数据

1515https://aacrjournals.org/cancerdiscovery/article-abstract/doi/10.1158/2159-8290.CD-24-1515/763959/Eradicating-Drug-Tolerant-Persister-Cells-in-EGFR?redirectedFrom=fulltext

YiZeng,ChenyangHuang,QiangqiangHou,WenhuaJiang,JiaqiCheng,XiaoxingWuDesign,synthesis,andevaluationofdualsonofsevenless1(SOS1)andepidermalgrowthfactorreceptor(EGFR)...

MiaoNiu*DiscoveryofaPotentDualSonofSevenless1(SOS1)andEpidermalGrowthFactorReceptor(EGFR)InhibitorfortheTreatmentofProstateCancerJournalofMedicinalChemistry2024J.Med.Chem.2024,...

J.G.Eriksen?C.Maare?J.Johansen?H.Primdahl?J.F.Evensen?C.A.Kristensen?L.J.Andersen6?J.OvergaardEvaluationoftheEGFR-...46510.1016/j.ijrobp.2013.11.021...

Large-scalemanufacturingofGMP-compliantanti-EGFRtargetednanocarriers:productionofdoxorubicin-loadedanti-EGFR-immunoliposomesforafirst-in-manclinicaltrialLarge-...

然而，一些关键基因（如tp53、egfr、kras、idh1等）特定位点的突变可能严重干扰蛋白功能，触发疾玻判断某一突变是否具有致病性，需结合多个维度考量：1.该位点是否位于蛋白功能结构域；2....

求吉非替尼或奥西替尼耐药的PC-9或HCC827细胞系，可有偿

适用于研究肿瘤发生机制、驱动基因突变（如EGFR、KRAS、TP53等）的功能影响。药物筛选与个性化治疗：高通量药物测试可预测患者对化疗、靶向治疗或免疫治疗的敏感性，辅助临床决策。例如：结...

DimaA.Sabbah*,RimaHajjoandKamalSweidanReviewonEpidermalGrowthFactorReceptor(EGFR)Structure,SignalingPathways,Interactions,...www.eurekaselect.com/article/104976Volume20,Issue10,...

L.Wang;ShengchenSu;XiaolanLv;YuxinLiu;Fang‐\MingChen;etalP4.11D.05EGFRNeoantigenPeptideVaccineCombinedwithTislelizumabandChemotherapyforAdvancedNSCLCResistanttoEGFR-...

CaicunZhou,Ke-JingTang,ByoungChulChoAmivantamabplusChemotherapyinNSCLCwithEGFRExon20InsertionsNEnglJMed2023389(22):2039-2051.10.1056/NEJMoa2306441.Epub2023Oct21....

Dr.PrateekPathak,Dr.HrvojeRimac,Dr.MariaGrishina,Dr.AmitaVerma,Dr.VladimirPotemkinHybridQuinazoline1,3,5-TriazinesasEpidermalGrowthFactorReceptor(EGFR)...Design,Synthesis,...

A.B.Shvetsov&A.V.SemenovCovalentEpidermalGrowthFactorReceptor(EGFR)InhibitorsinTargetedTherapyofDrug-ResistantNon-SmallCellLungCancer(AReview)...2283–2311...

JianjianZhuangTtAgo-coupled-multiplex-digtal-RPA-CRISPR/Cas12a(TCMDC)forEGFRmutationsdetectionTalantaVolume283,1February2025,127162TalantaVolume283,1February2025,127162...

YuanpingLu12,NuoyaYin12,FrancescoFaiolaTranscriptomicIntegrationAnalysesUncoverCommonBisphenolAEffectsAcrossSpeciesandTissuesPrimarilyMediatedbyDisruptionofJUN/FOS,EGFR,ER,...

ByoungCChoAmivantamabplusLazertinibinPreviouslyUntreatedEGFR-MutatedAdvancedNSCLCNEnglJMed2024Oct24391(16):1486-149810.1056/NEJMoa2403614