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作者：Jiasharete Jielile, Minawa Aibai, Gulnur Sabirhazi, Nuerai Shawutali, Wulanbai Tangkejie, Aynaz Badelhan, Yeermike Nuerduola, Turde Satewalede, Darehan Buranbai, Beicen Hunapia, Ayidaer Jialihasi, Jingping Bai, Murat Kizaibek
题目：Active Achilles tendon kinesitherapy accelerates Achilles tendon repair by promoting neurite regeneration
出版源：Neural Regeneration Research, 2012, 7(35): 2801.

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Active Achilles tendon kinesitherapy accelerates Achilles tendon repair by promoting neurite regeneration
作者:Jielile, J (Jielile, Jiasharete)[ 1,2 ] ; Aibai, M (Aibai, Minawa)[ 3 ] ; Sabirhazi, G (Sabirhazi, Gulnur)[ 4 ] ; Shawutali, N (Shawutali, Nuerai)[ 1,2 ] ; Tangkejie, W (Tangkejie, Wulanbai)[ 1,2 ] ; Badelhan, A (Badelhan, Aynaz)[ 1,2 ] ; Nuerduola, Y (Nuerduola, Yeermike)[ 1,2 ] ; Satewalede, T (Satewalede, Turde)[ 1,2 ] ; Buranbai, D (Buranbai, Darehan)[ 1,2 ] ; Hunapia, B (Hunapia, Beicen)[ 1,2 ] ; Jialihasi, A (Jialihasi, Ayidaer)[ 1,2 ] ; Bai, JP (Bai, Jingping)[ 5 ] ; Kizaibek, M (Kizaibek, Murat)[ 6 ] 更多内容更少内容

NEURAL REGENERATION RESEARCH

卷: 7
期: 35
页: 2801-2810
DOI: 10.3969/j.issn.1673-5374.2012.35.008

出版年: DEC 15 2012

查看期刊信息

NEURAL REGENERATION RESEARCH

出版商 SHENYANG EDITORIAL DEPT NEURAL REGENERATION RES, PO BOX 1234, SHENYANG, LIAONING 110004, PEOPLES R CHINA

ISSN: 1673-5374

研究领域 Cell Biology
Neurosciences & Neurology

摘要
Active Achilles tendon kinesitherapy facilitates the functional recovery of a ruptured Achilles tendon. However, protein expression during the healing process remains a controversial issue. New Zealand rabbits, aged 14 weeks, underwent tenotomy followed immediately by Achilles tendon microsurgery to repair the Achilles tendon rupture. The tendon was then immobilized or subjected to postoperative early motion treatment (kinesitherapy). Mass spectrography results showed that after 14 days of motion treatment, 18 protein spots were differentially expressed, among which, 12 were up-regulated, consisting of gelsolin isoform b and neurite growth-related protein collapsing response mediator protein 2. Western blot analysis showed that gelsolin isoform b was up-regulated at days 7-21 of motion treatment. These findings suggest that active Achilles tendon kinesitherapy promotes the neurite regeneration of a ruptured Achilles tendon and gelsolin isoform b can be used as a biomarker for Achilles tendon healing after kinesitherapy.

关键词
作者关键词:achilles tendon rupture; early; motion; functional exercise; exercise; Achilles tendon; healing; proteomics; marker; tissue repair

KeyWords Plus:SURGICAL REPAIR; FUNCTIONAL TREATMENT; KEY REGULATORS; RUPTURE; PROTEINS; GELSOLIN; CRMP-2; REHABILITATION; IMMOBILIZATION; WEIGHTBEARING

作者信息
通讯作者地址: Bai, JP (通讯作者) Xinjiang Med Univ, Teaching Hosp 3, Dept Orthoped, 30 Beijing S Rd, Urumqi 830011, Xinjiang Uyghur, Peoples R China.
  增强组织信息的名称
Xinjiang Medical University

地址:  [ 1 ] Xinjiang Med Univ, Teaching Hosp 1, Dept Microsurg Repair & Reconstruct, Urumqi 830054, Xinjiang Uyghur, Peoples R China
  增强组织信息的名称
Xinjiang Medical University
   [ 2 ] Res Inst Orthoped Xinjiang Uyghur Autonomous Reg, Sports Med Res Ctr, Urumqi 830054, Xinjiang Uyghur, Peoples R China
   [ 3 ] Urumqi Ctr Dis Control & Prevent, Urumqi 830026, Xinjiang Uyghur, Peoples R China
[ 4 ] Chinese Acad Sci, Xinjiang Inst Ecol & Geog, Urumqi 830011, Xinjiang Uyghur, Peoples R China
  增强组织信息的名称
Chinese Academy of Sciences
[ 5 ] Xinjiang Med Univ, Teaching Hosp 3, Dept Orthoped, Urumqi 830011, Xinjiang Uyghur, Peoples R China
  增强组织信息的名称
Xinjiang Medical University
   [ 6 ] Res Inst Kazakh Tradit Med Ili Kazakh Autonomous, Yining 835000, Ili Kazakh Auto, Peoples R China

电子邮件地址:jingping_bai@163.com

基金资助致谢
基金资助机构授权号
National Natural Science Foundation of China  30760256
查看基金资助信息关闭基金资助信息

This study was financially supported by the National Natural Science Foundation of China, No. 30760256.

出版商
SHENYANG EDITORIAL DEPT NEURAL REGENERATION RES, PO BOX 1234, SHENYANG, LIAONING 110004, PEOPLES R CHINA

类别 / 分类
研究方向:Cell Biology; Neurosciences & Neurology

Web of Science 类别:Cell Biology; Neurosciences

文献信息
文献类型:Article

语种:English

入藏号: WOS:000313148100008

PubMed ID: 25317130

ISSN: 1673-5374

其他信息
IDS 号: 065KV

Web of Science 核心合集中的 "引用的参考文献": 51

Web of Science 核心合集中的 "被引频次": 2

影响因子 0.22  0.205
2014  5 年

JCR® 类别类别中的排序 JCR 分区
CELL BIOLOGY  182/184  Q4
NEUROSCIENCES  247/252  Q4

数据来自第 2014 版 Journal Citation Reports®

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