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This report describes the development and scale up of the synthesis of oxaisoxazolidinone 1, a significant synthon in the synthesis of the MRSA development compound AZD5847. Studies were carried out to ensure a short-term, risk based preparation of 9 on a 5 L scale with a solid isolation procedure and a safe, long-term manufacturing process for both 1 and 9 through extensive hazards evaluation. ·¢×ÔСľ³æIOS¿Í»§¶Ë |
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781934544: ½ð±Ò+10 2016-01-12 19:35:08
781934544: ½ð±Ò+10 2016-01-12 19:35:08
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