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【答案】应助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
感谢参与，应助指数 +1
sunhqliuzh: 金币+40, ★★★★★最佳答案, 谢谢！！ 2015-12-06 18:28:12
心静_依然: LS-EPI+1, 感谢应助 2015-12-06 18:43:18
EI收录
Accession number:
20152801022864
Title: Oxidative stress damage from nanometer titanium dioxide in goldfish brain tissue
Authors: Sun, Huiqun1 Email author sunhqliuzh@163.com; Zhang, Qun1; Chen, Shuqin1; Cao, Jingjing1
Author affiliation: 1 Resources and Environment Department of Anqing Teachers College, Anqing, China
Source title: Research of Environmental Sciences
Abbreviated source title: Res. Environ. Sci.
Volume: 28
Issue: 6
Issue date: June 1, 2015
Publication year: 2015
Pages: 930-935
Language: Chinese
ISSN: 10016929
Document type: Journal article (JA)
Publisher: Editorial department of Molecular Catalysis, Tianshui Road No. 18, Lanzhou City, Gansu Province,, 730000, China
Abstract: In order to investigate the oxidative damage mechanism of photocatalytic type nano-TiO<inf>2</inf> on goldfish brain tissue, a test involving the content of malondialdehyde (MDA), protein carbonyl (PC) and H<inf>2</inf>O<inf>2</inf> in goldfish brain tissues together with the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) and the expression of Cu/Zn-SOD protein was determined after goldfishes were exposed to different nano-TiO<inf>2</inf> concentrations of 0, 16, 32, 64 and 128 mg/L. The results showed that the Cu/Zn-SOD activity in goldfish brain tissues decreased from 1.70×10<sup>-3</sup> kat/kg to 0.35×10<sup>-3</sup> kat/kg, and then rebounded to 0.46×10<sup>-3</sup> kat/kg with the nano-TiO<inf>2</inf> concentration varying from 0 to 128 mg/L. Meanwhile, the Mn-SOD activity presented a decrease-increase-decrease trend; the MDA content increased from 0.85 to 2.83 nmol/g, and then decreased to 2.54 nmol/g. The PC content increased all the way when the H<inf>2</inf>O<inf>2</inf> content increased from 4.32 to 9.28 μmol/g, and then decreased to 8.38 μmol/g. When the nano-TiO<inf>2</inf> concentration increased, the expression of Cu/Zn-SOD decreased gradually. The research indicated that nano-TiO<inf>2</inf> strongly affected the oxidative damage in goldfish brain tissues. The increase of the MDA and PC content was associated with the decreasing of the Cu/Zn-SOD and GPx activity, while H<inf>2</inf>O<inf>2</inf> has a bearing on the GPx activity and other factors. ©, 2015, Editorial department of Molecular Catalysis. All right reserved.
Number of references: 32
Main heading: Brain
Controlled terms: Aldehydes - Enzymes - Gold - Histology - Manganese - Oxides - Oxygen - Peptides - Plants (botany) - Proteins - Tissue - Titanium - Titanium dioxide
Uncontrolled terms: Glutathione peroxidase - Malondialdehyde - Nanometer titanium dioxide - Oxidative damage - Protein carbonyls - Super oxide dismutase
Classification code: 461 Bioengineering and Biology - 542.3 Titanium and Alloys - 543.2 Manganese and Alloys - 547.1 Precious Metals - 804 Chemical Products Generally
DOI: 10.13198/j.issn.1001-6929.2015.06.13
Database: Compendex
Compilation and indexing terms, © 2015 Elsevier Inc. |
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