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Accession number:       
20152801022864
        Title:        Oxidative stress damage from nanometer titanium dioxide in goldfish brain tissue
        Authors:         Sun, Huiqun1 Email author sunhqliuzh@163.com; Zhang, Qun1; Chen, Shuqin1; Cao, Jingjing1
        Author affiliation:        1 Resources and Environment Department of Anqing Teachers College, Anqing, China
        Source title:        Research of Environmental Sciences
        Abbreviated source title:        Res. Environ. Sci.
        Volume:        28
        Issue:        6
        Issue date:        June 1, 2015
        Publication year:        2015
        Pages:        930-935
        Language:        Chinese
        ISSN:         10016929
        Document type:        Journal article (JA)
        Publisher:        Editorial department of Molecular Catalysis, Tianshui Road No. 18, Lanzhou City, Gansu Province,, 730000, China
        Abstract:        In order to investigate the oxidative damage mechanism of photocatalytic type nano-TiO<inf>2</inf> on goldfish brain tissue, a test involving the content of malondialdehyde (MDA), protein carbonyl (PC) and H<inf>2</inf>O<inf>2</inf> in goldfish brain tissues together with the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) and the expression of Cu/Zn-SOD protein was determined after goldfishes were exposed to different nano-TiO<inf>2</inf> concentrations of 0, 16, 32, 64 and 128 mg/L. The results showed that the Cu/Zn-SOD activity in goldfish brain tissues decreased from 1.70¡Á10<sup>-3</sup> kat/kg to 0.35¡Á10<sup>-3</sup> kat/kg, and then rebounded to 0.46¡Á10<sup>-3</sup> kat/kg with the nano-TiO<inf>2</inf> concentration varying from 0 to 128 mg/L. Meanwhile, the Mn-SOD activity presented a decrease-increase-decrease trend; the MDA content increased from 0.85 to 2.83 nmol/g, and then decreased to 2.54 nmol/g. The PC content increased all the way when the H<inf>2</inf>O<inf>2</inf> content increased from 4.32 to 9.28 ¦Ìmol/g, and then decreased to 8.38 ¦Ìmol/g. When the nano-TiO<inf>2</inf> concentration increased, the expression of Cu/Zn-SOD decreased gradually. The research indicated that nano-TiO<inf>2</inf> strongly affected the oxidative damage in goldfish brain tissues. The increase of the MDA and PC content was associated with the decreasing of the Cu/Zn-SOD and GPx activity, while H<inf>2</inf>O<inf>2</inf> has a bearing on the GPx activity and other factors. ©, 2015, Editorial department of Molecular Catalysis. All right reserved.
        Number of references:        32
        Main heading:         Brain
        Controlled terms:         Aldehydes - Enzymes - Gold - Histology - Manganese - Oxides - Oxygen - Peptides - Plants (botany) - Proteins - Tissue - Titanium - Titanium dioxide
        Uncontrolled terms:         Glutathione peroxidase - Malondialdehyde - Nanometer titanium dioxide - Oxidative damage - Protein carbonyls - Super oxide dismutase
        Classification code:         461 Bioengineering and Biology - 542.3 Titanium and Alloys - 543.2 Manganese and Alloys - 547.1 Precious Metals - 804 Chemical Products Generally
        DOI:        10.13198/j.issn.1001-6929.2015.06.13
        Database:        Compendex
                Compilation and indexing terms, © 2015 Elsevier Inc.
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