| ²é¿´: 1132 | »Ø¸´: 6 | |||
| ±¾Ìû²úÉú 1 ¸ö ·ÒëEPI £¬µã»÷ÕâÀï½øÐв鿴 | |||
Ô¬Ð¡Ð¡È»Òø³æ (ÕýʽдÊÖ)
|
[ÇóÖú]
°ïæ·ÒëһϾä×Ó
|
||
|
¿´ÎÄÏ×Óм¸¸ö¾ä×Ӹоõ¿´²»Ì«¶®£¬Ï£Íû³æÓѰïÎÒ·Òëһϣ¡Ð»Ð»£¡ ÊǸúÉúÎïҽѧÏà¹ØµÄÎÄÏס£ 1¡¢In the gut, we observed significant reduction of Th17 cells in lamina propria lymphocytes (LPL) of small intestine in adultATB mice compared with controls , consistent with the profile of IL-17 in the skin . 2¡¢Furthermore, the frequencies of IL-22t T cells and IL-22tab T cells were both significantly decreased in adult ATB, compared with control mice without antibiotic treatment . 3¡¢Decrease of Th17 cells corresponded to the decrease in the expression of CCR6 in TCRbtCD4t T cells in the gut; a chemokine receptor required for migration of gut Th17 cells to the skin inflammatory tissues21 . 4¡¢Thus, we have demonstrated that the decrease in IL-22t and IL-17t T cells in the skin is likely a primary factor that accounts for the amelioration of the skin disease in mice depleted of gut bacteria. 5.At the phylum level, we have observed decreased abundance of Bacteroidetes (Kruskal¨CWallis test, P=0.04953), Actinobacteria (Kruskal¨C Wallis test, P=0.0463) and Cyanobacteria (Kruskal¨CWallis test, P=0.0369) in adultATB mice . »¹Óм¸¸öÃû´Ê²»Ì«¶®£¬Ï£Íû³æÓѰïÎÒ½âÊÍһϠadultATB mice£»observed operational taxonomic units (OTUs)£»observed operational taxonomic units (OTUs)£»lamina propria lymphocytes (LPL)£»Th17 cell £¨ÕâÊÇÒ»ÖÖʲôϸ°û£©£»TopATB herein лл³æÓÑ£¡£¡£¡£¡ |
» ²ÂÄãϲ»¶
Çó²ÄÁϵ÷¼Á
ÒѾÓÐ6È˻ظ´
085600²ÄÁÏÓ뻯¹¤
ÒѾÓÐ5È˻ظ´
085600²ÄÁÏÓ뻯¹¤µ÷¼Á 324·Ö
ÒѾÓÐ6È˻ظ´
286Çóµ÷¼Á
ÒѾÓÐ9È˻ظ´
½¹ÂÇ
ÒѾÓÐ12È˻ظ´
344Çóµ÷¼Á
ÒѾÓÐ6È˻ظ´
266Çóµ÷¼Á
ÒѾÓÐ9È˻ظ´
»¯Ñ§¹¤³Ì321·ÖÇóµ÷¼Á
ÒѾÓÐ18È˻ظ´
314Çóµ÷¼Á
ÒѾÓÐ8È˻ظ´
08¹¤¿Æ 320×Ü·Ö Çóµ÷¼Á
ÒѾÓÐ5È˻ظ´

ԬССȻ
Òø³æ (ÕýʽдÊÖ)
- Ó¦Öú: 4 (Ó×¶ùÔ°)
- ½ð±Ò: 604.5
- É¢½ð: 88
- ºì»¨: 3
- Ìû×Ó: 545
- ÔÚÏß: 69.3Сʱ
- ³æºÅ: 2643287
- ×¢²á: 2013-09-09
- ÐÔ±ð: GG
- רҵ: ʳƷ¿ÆÑ§»ù´¡

2Â¥2015-10-12 18:03:00
|
3Â¥2015-10-12 20:29:47
ԬССȻ
Òø³æ (ÕýʽдÊÖ)
- Ó¦Öú: 4 (Ó×¶ùÔ°)
- ½ð±Ò: 604.5
- É¢½ð: 88
- ºì»¨: 3
- Ìû×Ó: 545
- ÔÚÏß: 69.3Сʱ
- ³æºÅ: 2643287
- ×¢²á: 2013-09-09
- ÐÔ±ð: GG
- רҵ: ʳƷ¿ÆÑ§»ù´¡

4Â¥2015-10-12 22:24:18
ssssllllnnnn
ÖÁ×ðľ³æ (ÖªÃû×÷¼Ò)
Translator and Proofreader
- ·ÒëEPI: 1690
- Ó¦Öú: 452 (˶ʿ)
- ½ð±Ò: 31580.9
- ºì»¨: 100
- Ìû×Ó: 7681
- ÔÚÏß: 19966.6Сʱ
- ³æºÅ: 3328089
- ×¢²á: 2014-07-17
- רҵ: Ö×Áö·¢Éú
¡¾´ð°¸¡¿Ó¦Öú»ØÌû
¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï
ԬССȻ: ½ð±Ò+30, ·ÒëEPI+1, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸ 2015-10-13 09:59:58
ԬССȻ(RXMCDM´ú·¢): ½ð±Ò+20 2015-10-17 08:03:07
ԬССȻ: ½ð±Ò+30, ·ÒëEPI+1, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸ 2015-10-13 09:59:58
ԬССȻ(RXMCDM´ú·¢): ½ð±Ò+20 2015-10-17 08:03:07
|
Õâλͬѧ£¬ÒÔºó²»ÒªÌ«Ì°ÁË£¬ÄãµÄ¶«Î÷±¾À´¾Í²»ÊÇÿ¸öÈ˶¼¿ÉÒԻشðµÄ£¬ËùÒÔÒ»´Î²»ÒªÇóÖúÌ«¶àÄÚÈÝ£¬·ñÔò²»»áÓÐÈ˰ïÖúÄ㡣ÿ´ÎÎÊÒ»¸öÎÊÌâ¾ÍºÃ¡£ ÁíÍ⣬ÕâЩ¶àÊý¶¼ÊǺܻù´¡µÄ¶«Î÷£¬··½Ì¿ÆÊé¶¼¿ÉÒÔ¿´Ã÷°×µÄ¡£ 1¡¢In the gut, we observed significant reduction of Th17 cells in lamina propria lymphocytes (LPL) of small intestine in adult ATB mice compared with controls , consistent with the profile of IL-17 in the skin. 1¡¢Óë¶ÔÕÕ×éÏà±È£¬³ÉÄêСÊ󾿹ÉúËØ´¦Àíºó£¬ÔÚ³¦µÀÖУ¬ÎÒÃǹ۲쵽ÔÚС³¦¹ÌÓвãÁܰÍϸ°û£¨LPL£©ÖÐTh17ϸ°ûÏÔÖø¼õÉÙ£¬ÓëÔÚÆ¤·ôÖÐIL-17µÄÇé¿öÏàͬ¡£ 2¡¢Furthermore, the frequencies of IL-22t T cells and IL-22tab T cells were both significantly decreased in adult ATB, compared with control mice without antibiotic treatment. 2¡¢¶øÇÒ£¬Óëδ¾¿¹ÉúËØ´¦ÀíµÄ¶ÔÕÕ×éСÊó±È½Ï£¬ATB³ÉÄêСÊóµÄIL-22t Tϸ°ûºÍIL-22tab Tϸ°ûµÄƵÂʾùÃ÷ÏÔ½µµÍ¡£ 3¡¢Decrease of Th17 cells corresponded to the decrease in the expression of CCR6 in TCRbtCD4t T cells in the gut; a chemokine receptor required for migration of gut Th17 cells to the skin inflammatory tissues. 3¡¢ÔÚ³¦µÀÖУ¬Th17ϸ°ûµÄ¼õÉÙºÍÔÚTCRbtCD4t Tϸ°ûÖÐCCR6µÄ±í´ï¼õÉÙÏà¶ÔÓ¦; CCR6Êdz¦µÀÖÐTh17ϸ°ûÏòƤ·ôÑ×Ö¢×éÖ¯Ç¨ÒÆµÄÒ»ÖÖÇ÷»¯Òò×ÓÊÜÌå¡£ 4¡¢Thus, we have demonstrated that the decrease in IL-22t and IL-17t T cells in the skin is likely a primary factor that accounts for the amelioration of the skin disease in mice depleted of gut bacteria. 4¡¢Òò´Ë£¬ÎÒÃÇÒѾ±íÃ÷£¬ÔÚÆ¤·ôÖÐIL-22tºÍIL-17t Tϸ°ûµÄ¼õÉÙ¿ÉÄÜÊÇÔÚ³¦µÀϸ¾úºÄ¾¡µÄСÊóÖÐÒýÆðƤ·ô¼²²¡¸ÄÉÆµÄÖ÷ÒªÒòËØ¡£ 5¡¢At the phylum level, we have observed decreased abundance of Bacteroidetes (Kruskal¨CWallis test, P=0.04953), Actinobacteria (Kruskal¨C Wallis test, P=0.0463) and Cyanobacteria (Kruskal¨CWallis test, P=0.0369) in adult ATB mice. 5¡¢ÔÚÃÅÒ»¼¶Ë®Æ½£¬ÎÒÃÇÒѾ¹Û²ìµ½ÔÚ¿¹ÉúËØ´¦ÀíµÄ³ÉÄêСÊóÖУ¬ÓÐÄâ¸Ë¾ú£¨ÖȺͼìÑé¼ìÑ飬 P=0.04953£©£¬·ÅÏß¾ú£¨ÖȺͼìÑé¼ìÑ飬P=0.0463£©ºÍÀ¶Ô壨ÖȺͼìÑé¼ìÑ飬P=0.0369£©ÊýÁ¿µÄ¼õÉÙ¡£ adult ATB mice£º¾¿¹ÉúËØ´¦ÀíµÄ³ÉÄêСÊó£» observed operational taxonomic units (OTUs)£º¹Û²ìµ½µÄ²Ù×÷·ÖÀ൥Ԫ£» lamina propria lymphocytes (LPL)£º¹ÌÓвãÁܰÍϸ°û£» Th17 cell£º²úÉúIL-17µÄ¸¨ÖúTϸ°û£» TopATB herein£º´Ë´¦ÓÃTopATB±íʾ£¬TopATBΪ¾Ö²¿Ê¹Óÿ¹ÉúËØ |
5Â¥2015-10-13 01:27:53
ԬССȻ
Òø³æ (ÕýʽдÊÖ)
- Ó¦Öú: 4 (Ó×¶ùÔ°)
- ½ð±Ò: 604.5
- É¢½ð: 88
- ºì»¨: 3
- Ìû×Ó: 545
- ÔÚÏß: 69.3Сʱ
- ³æºÅ: 2643287
- ×¢²á: 2013-09-09
- ÐÔ±ð: GG
- רҵ: ʳƷ¿ÆÑ§»ù´¡

6Â¥2015-10-13 09:59:48
ԬССȻ
Òø³æ (ÕýʽдÊÖ)
- Ó¦Öú: 4 (Ó×¶ùÔ°)
- ½ð±Ò: 604.5
- É¢½ð: 88
- ºì»¨: 3
- Ìû×Ó: 545
- ÔÚÏß: 69.3Сʱ
- ³æºÅ: 2643287
- ×¢²á: 2013-09-09
- ÐÔ±ð: GG
- רҵ: ʳƷ¿ÆÑ§»ù´¡

7Â¥2015-10-13 15:17:08













»Ø¸´´ËÂ¥
