Anti-aging activities of polysaccharides from Athyrium multidentatum (Doll.) Ching.
作者:
Dongmei Liu1
Jiwen Sheng1
Huimin Qi1
Weifen Zhang1
来源:
Journal of Chemical & Pharmaceutical Research. 2015, Vol. 7 Issue 1, p386-389. 4p.
文献类型:
Article
主题语:
*AGING -- Prevention
*ATHYRIUM
*POLYSACCHARIDES
*RESEARCH
*ANTIOXIDANTS
*LIPASES
作者提供的关键字:
Anti-aging
Athyrium multidentatum (Doll.) Ching
D-galactose
Polysaccharides
摘要:
In this paper, the anti-aging effect of polysaccharides extracted from Athyrium multidentatum (Doll.) Ching (PA) was investigated on aged mice induced by D-galactose. After administration of PA for 40 days, SOD, CAT and GSH-Px activities in PA groups was significantly enhanced and MDA level was decreased compared with aged group. There were significant differences between PA high dosage group and aged group (P < 0.05). SOD activity in PA high dosage group was 123.7 ± 12.5 U/mL, which was stronger than VE group and similar to normal group. The antioxidative enzyme activities in mice were increased in dose-dependent patterns. These results demonstrated that PA could remarkably augment the activities of antioxidative enzymes and lessen the product of lipid peroxide, which might provide an explicit interpretation to the anti-aging mechanism of PA. [ABSTRACT FROM AUTHOR]
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作者单位:
1Department of Pharmacy, Weifang Medical University, Weifang, PR China
ISSN:
0975-7384
入藏编号:
100833075
数据库:
Academic Search Premier
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