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Anti-aging activities of polysaccharides from Athyrium multidentatum (Doll.) Ching. 作者: Dongmei Liu1 Jiwen Sheng1 Huimin Qi1 Weifen Zhang1 来源: Journal of Chemical & Pharmaceutical Research. 2015, Vol. 7 Issue 1, p386-389. 4p. 文献类型: Article 主题语: *AGING -- Prevention *ATHYRIUM *POLYSACCHARIDES *RESEARCH *ANTIOXIDANTS *LIPASES 作者提供的关键字: Anti-aging Athyrium multidentatum (Doll.) Ching D-galactose Polysaccharides 摘要: In this paper, the anti-aging effect of polysaccharides extracted from Athyrium multidentatum (Doll.) Ching (PA) was investigated on aged mice induced by D-galactose. After administration of PA for 40 days, SOD, CAT and GSH-Px activities in PA groups was significantly enhanced and MDA level was decreased compared with aged group. There were significant differences between PA high dosage group and aged group (P < 0.05). SOD activity in PA high dosage group was 123.7 ± 12.5 U/mL, which was stronger than VE group and similar to normal group. The antioxidative enzyme activities in mice were increased in dose-dependent patterns. These results demonstrated that PA could remarkably augment the activities of antioxidative enzymes and lessen the product of lipid peroxide, which might provide an explicit interpretation to the anti-aging mechanism of PA. [ABSTRACT FROM AUTHOR] Copyright of Journal of Chemical & Pharmaceutical Research is the property of Journal of Chemical & Pharmaceutical Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) 作者单位: 1Department of Pharmacy, Weifang Medical University, Weifang, PR China ISSN: 0975-7384 入藏编号: 100833075 数据库: Academic Search Premier |
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