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【答案】应助回帖
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爱与雨下: 金币+1 2015-07-03 20:46:18
不辜负: 金币+5, 翻译EPI+1, ★★★很有帮助, 谢谢你噢 2015-07-08 01:19:58
In mitochondrion, a small portion (about 15%) of cyt c is tightly bound to the membrane while the remainder is free or loosely bound [1,2]. The unbound cyt c participates in eT and actively prevents oxidative stress,while membrane-bound cyt c ismainly involved in cell death. To initiate the apoptotic process the protein acquires peroxidase activity, an event which favors protein dissociation from the mitochondrial membrane [9,39,40] and the subsequent release of cyt c into the cytosol. Among the phospholipids constituting the mitochondrial membrane, CL is known to bind the hemoprotein [41]. Thus, the cyt c–CL interaction plays an important role in cells since it modulates the protein behavior determining whether cyt c should perform its ‘normal’ role in the respiratory chain or, conversely, is to be released into the cytosol where it participates in the apoptotic event (see [40] and references therein). Unlike the equine protein, cyt c fromyeast does not participate in cell apoptosis [16,17].
在线粒体中，少部分（约 15%）cyt c 紧密结合于膜上，而其他的是游离的或松散地结合的 [1,2]. 未结合的 cyt c 参与 eT，积极地防止氧化胁迫，而膜结合的 cyt c 主要参与细胞死亡。 要开始细胞凋亡过程， 蛋白获得过氧化物酶活性，这一事件促进蛋白从线粒体膜上解离 [9,39,40]，以及随后的 cyt c 释放如胞质。i在组成线粒体膜的磷脂中，已知 CL 结合血红素蛋白[41]。 因此，cyt c–CL 相互作用在细胞中有重要功能，因为它调控蛋白行为，决定cyt c 在呼吸链中行使“正常”功能，或者想反，被释放到胞质中参与凋亡事件 (参见 [40] 及其参考文献). 与马中的蛋白不同，来自酵母的 cyt c 不参与细胞凋亡 [16,17]. |
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