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Çë°ïÎÒ²éÏÂweb of science ÊÇ·ñÄܼìË÷µ½ÕâÆªÎÄÕ£¬pubmedÉÏÒѾ¿ÉÒÔ¼ìË÷µ½£º Lei F, Gao Y, Liu F, Hou R, Cai RL, and Qi Y. Shuang-Huang-Lian Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice Involving Anti-Inflammatory and Antioxidative Activities. Evid Based Complement Alternat Med, 2015, doi: 10.1155/2015/283939. лл£¡ |
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sapphires008: ½ð±Ò+15, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸, лл£¡ 2015-06-11 08:02:48
Ðľ²_ÒÀÈ»: LS-EPI+1, ¸ÐлӦÖú 2015-06-11 08:34:15
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Shuang-huang-lian attenuates lipopolysaccharide-induced acute lung injury in mice involving anti-inflammatory and antioxidative activities. ×÷Õß:Fang, Lei; Gao, Yuan; Liu, Fen; Hou, Rui; Cai, Run-Lan; Qi, Yun Evidence-based complementary and alternative medicine : eCAM ¾í:2015 Ò³:283939 DOI:10.1155/2015/283939 ³ö°æÄê:2015 (Epub 2015 Apr 06) ÕªÒª Shuang-Huang-Lian (SHL) is a common traditional Chinese preparation extracted from Lonicerae Japonicae Flos, Scutellariae Radix, and Fructus Forsythiae. In this study, we demonstrate the anti-inflammatory and antioxidative effects of SHL on lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in mice. SHL reduced the lung wet/dry weight ratio, lowered the number of total cells in the bronchoalveolar lavage fluid, and decreased the myeloperoxidase activity in lung tissues 6h after LPS treatment. It also inhibited the overproduction of proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-6) in the bronchoalveolar lavage fluid. Histological studies demonstrated that SHL attenuated LPS-induced interstitial edema, hemorrhage, and the infiltration of neutrophils into the lung tissue. Moreover, SHL could also enhance the superoxide dismutase and catalase activities, increase the reduced glutathione content, and decrease the malondialdehyde content. The present results suggest that SHL possesses anti-inflammatory and antioxidative properties that may protect mice against LPS-induced ALI. ×÷ÕßÐÅÏ¢ µØÖ·:Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. ÎÄÏ×ÐÅÏ¢ ÎÄÏ×ÀàÐÍ:Journal Article ÓïÖÖ:English PubMed ID:25945107 NLM Ψһ ID:101215021 ´´½¨ÈÕÆÚ: 06 May 2015 Íê³ÉÈÕÆÚ: 06 May 2015 ÐÞ¶©ÈÕÆÚ: 08 May 2015 µç×Ó³ö°æ:06 Apr 2015 ¹ú¼Ò/µØÇø: United States ISSN:1741-427X ÆÚ¿¯ÐÅÏ¢ Impact Factor (Ó°ÏìÒò×Ó): Journal Citation Reports® ÆäËûÐÅÏ¢ ¼Ç¼ËùÓÐÕß:NLM ״̬ ubMed-not-MEDLINE |
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sapphires008
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