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Design of novel bis-benzimidazole derivatives as DNA minor groove binding agents
×÷Õß:Wang, XJ (Wang, Xiu-Jun)[ 1,2 ] ; Yang, ML (Yang, Ming Li)[ 2 ] ; Zhang, LP (Zhang, Lan-Ping)[ 2 ] ; Yao, T (Yao, Tong)[ 1,2 ] ; Chen, C (Chen, Cheng)[ 2 ] ; Mao, LG (Mao, Lian-Gang)[ 1,2 ] ; Wang, Y (Wang, Yin)[ 2 ] ; Wu, J (Wu, Jie)[ 3 ]
CHINESE CHEMICAL LETTERS
¾í: 25  ÆÚ: 4  Ò³: 589-592
DOI: 10.1016/j.cclet.2014.01.019
³ö°æÄê: APR 2014
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A new series of bis-benzimidazole derivatives were designed and synthesized. In vitro cytotoxicity evaluation showed that these compounds exhibited high activity against the selected tumor cells. Among them, compound 9 owned the best potential, its IC50 values being 5.95 mu mol/L (mononuclear tumor cell line (U937)) and 5.58 mu mol/L (cervical cancer cell (HeLa)). Fluorescence and UV-vis studies showed that compound 9 could bind into the minor groove of DNA. (C) 2014 Ming-Li Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
¹Ø¼ü´Ê
×÷Õ߹ؼü´Ê:Bis-benzimidazole; Anti-tumor; DNA minor groove
KeyWords Plus:ANTITUMOR
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ͨѶ×÷ÕßµØÖ·: Yang, ML (ͨѶ×÷Õß)
              JARI Pharmaceut Co Ltd, Lianyungang 222006, Peoples R China.
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              [ 1 ] 716th Inst CSIC, Lianyungang 222006, Peoples R China
              [ 2 ] JARI Pharmaceut Co Ltd, Lianyungang 222006, Peoples R China
              [ 3 ] Wuhan Bioengn Inst, Dept Pharmaceut Engn, Wuhan 430415, Peoples R China
µç×ÓÓʼþµØÖ·:Ymlwxj@126.com; tomson-wu@foxmail.com
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Wuhan City Department of Education         
20091(106)
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ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
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Ñо¿·½Ïò:Chemistry
Web of Science Àà±ð:Chemistry, Multidisciplinary
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ÎÄÏ×ÀàÐÍ:Article
ÓïÖÖ:English
Èë²ØºÅ: WOS:000335108000024
ISSN: 1001-8417
µç×Ó ISSN: 1878-5964
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IDS ºÅ: AG0LW
Web of Science ºËÐĺϼ¯ÖÐµÄ "ÒýÓõIJο¼ÎÄÏ×": 14
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