24小时热门版块排行榜

返回列表

本帖产生 1 个 LS-EPI ，点击这里进行查看

sunhw_hit

木虫 (正式写手)

永不落地的飞鸟

应助: 0 (幼儿园)
贵宾: 0.645
金币: 1225.1
散金: 50
红花: 2
帖子: 607
在线: 48.6小时
虫号: 435932
注册: 2007-08-25
专业: 声学

[求助] 请帮忙下载检索信息，pdf发送给我

请把下载的pdf的检索信息发给我
sunhw_hit@126.com

Design of novel bis-benzimidazole derivatives as DNA minor groove binding agents
作者:Wang, XJ (Wang, Xiu-Jun)[ 1,2 ] ; Yang, ML (Yang, Ming Li)[ 2 ] ; Zhang, LP (Zhang, Lan-Ping)[ 2 ] ; Yao, T (Yao, Tong)[ 1,2 ] ; Chen, C (Chen, Cheng)[ 2 ] ; Mao, LG (Mao, Lian-Gang)[ 1,2 ] ; Wang, Y (Wang, Yin)[ 2 ] ; Wu, J (Wu, Jie)[ 3 ]
CHINESE CHEMICAL LETTERS
卷: 25  期: 4  页: 589-592
DOI: 10.1016/j.cclet.2014.01.019
出版年: APR 2014
查看期刊信息
摘要
A new series of bis-benzimidazole derivatives were designed and synthesized. In vitro cytotoxicity evaluation showed that these compounds exhibited high activity against the selected tumor cells. Among them, compound 9 owned the best potential, its IC50 values being 5.95 mu mol/L (mononuclear tumor cell line (U937)) and 5.58 mu mol/L (cervical cancer cell (HeLa)). Fluorescence and UV-vis studies showed that compound 9 could bind into the minor groove of DNA. (C) 2014 Ming-Li Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
关键词
作者关键词:Bis-benzimidazole; Anti-tumor; DNA minor groove
KeyWords Plus:ANTITUMOR
作者信息
通讯作者地址: Yang, ML (通讯作者)
            JARI Pharmaceut Co Ltd, Lianyungang 222006, Peoples R China.
地址:
            [ 1 ] 716th Inst CSIC, Lianyungang 222006, Peoples R China
            [ 2 ] JARI Pharmaceut Co Ltd, Lianyungang 222006, Peoples R China
            [ 3 ] Wuhan Bioengn Inst, Dept Pharmaceut Engn, Wuhan 430415, Peoples R China
电子邮件地址:Ymlwxj@126.com; tomson-wu@foxmail.com
基金资助致谢
基金资助机构       授权号
Wuhan City Department of Education
20091(106)
查看基金资助信息
出版商
ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
类别 / 分类
研究方向:Chemistry
Web of Science 类别:Chemistry, Multidisciplinary
文献信息
文献类型:Article
语种:English
入藏号: WOS:000335108000024
ISSN: 1001-8417
电子 ISSN: 1878-5964
其他信息
IDS 号: AG0LW
Web of Science 核心合集中的 "引用的参考文献": 14
Web of Science 核心合集中的 "被引频次": 0

回复此楼

» 猜你喜欢

上帝给我机会选择交换，于是我用自己的双足换做一对翅膀！

1楼 2014-12-12 16:21:06

已阅回复此楼关注TA 给TA发消息送TA红花 TA的回帖

Paulwolf

荣誉版主 (文坛精英)

非线性控制领域新人一枚

专家经验: +178
LS-EPI: 107
应助: 317 (大学生)
贵宾: 4.423
金币: 310300
散金: 17941
红花: 554
沙发: 3382
帖子: 35712
在线: 4027.9小时
虫号: 3131175
注册: 2014-04-12
专业: 控制理论与方法
管辖: 学术会议

【答案】应助回帖

★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
感谢参与，应助指数 +1
sunhw_hit: 金币+20, ★有帮助 2014-12-12 16:38:28
jssxh: LS-EPI+1, 谢谢参与，请继续关注本版块 2014-12-12 17:27:30

http://yunpan.cn/cf3Ccpdn9aVcC 提取码 518b