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作者：J. Chen, H. Wu, MM Dai, H Li, JY Chen, SL Hu. 文章名： Identification and distribution of four metabolites of geniposide in rats with adjuvant arthritis. 期刊： Fitoterapia 年期页码 97(2014) 111-121. 该文章属于SCI-Expanded数据库。 现在急切需要，望好心人帮帮忙。不胜感激！ |
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2楼2014-11-17 13:56:12
muse
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jchen2014(sunshan4379代发): 金币+20 2014-11-26 09:18:21
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Identification and distribution of four metabolites of geniposide in rats with adjuvant arthritis 作者:Chen, J (Chen, Jian)[ 1 ] ; Wu, H (Wu, Hong)[ 1 ] ; Dai, MM (Dai, Miao-Miao)[ 1 ] ; Li, H (Li, Hui)[ 1 ] ; Chen, JY (Chen, Jin-Yun)[ 1 ] ; Hu, SL (Hu, Shun-Li)[ 1 ] FITOTERAPIA 卷: 97 页: 111-121 DOI: 10.1016/j.fitote.2014.05.023 出版年: SEP 2014 查看期刊信息 摘要 Geniposide (GE), also called Jasminoidin, is the major active ingredient of Gardenia jasminoides Ellis (GJ) fruit, which has long been used in traditional Chinese medicine (TCM). Growing evidences suggested that GE has a great potentiality for treating rheumatoid arthritis (RA). However, GE is rapidly metabolized, and we know little about its availability or metabolites in tissues. To elucidate the distribution of GE and its metabolites in tissues, three groups of adjuvant arthritis (AA) rats were given GE (33,66 and 120 mg/kg) from days 18 to 24, and the biotransformation of GE in plasma, liver, spleen, synovium, urine and mesenteric lymph node (MLN) of rats was investigated by a novel approach named Information-Dependent Acquisition (IDA)-Mediated LC-MS/MS method. As a result, GE and its four major metabolites were detected as follows: GE, G1, G2 in plasma; GE, G2 in MLNs; only GE in liver and synovium; GE, G2, G3 and G4 in spleen; and GE, Gl, G2 and G4 in urine. In total four metabolites (G1-G4) involved in the in vivo metabolism processes were identified. The results of this work have demonstrated the IDA-Mediated LC-MS/MS could screen rapidly and reliably the characterization of metabolites from iridoid compounds. (c) 2014 Elsevier B.V. All rights reserved. 关键词 作者关键词:Geniposide; Metabolites Information-Dependent Acquisition (IDA); LC-MS/MS; Adjuvant arthritis KeyWords Plus:TANDEM MASS-SPECTROMETRY; INFORMATION-DEPENDENT ACQUISITION; RHEUMATOID-ARTHRITIS; GARDENIA-JASMINOIDES; SCREENING-PROCEDURE; GENIPIN; PHARMACOKINETICS; GLUCOSIDE; URINE; MS/MS 作者信息 通讯作者地址: Wu, H (通讯作者) Anhui Univ Chinese Med, Coll Pharm, Hefei 230031, Peoples R China. 地址: [ 1 ] Anhui Univ Chinese Med, Coll Pharm, Key Lab Modernized Chinese Med Anhui Prov, Hefei 230031, Anhui, Peoples R China 电子邮件地址:hongw@aliyun.com 基金资助致谢 基金资助机构 授权号 National Natural Science Foundation of China 81073122 Anhui Provincial Natural Science Research Project of University KJ2009A045Z youth Natural Science Foundation of Anhui University of Chinese Medicine qn201308 查看基金资助信息 出版商 ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 类别 / 分类 研究方向  harmacology & PharmacyWeb of Science 类别:Chemistry, Medicinal; Pharmacology & Pharmacy 文献信息 文献类型:Article 语种:English 入藏号: WOS:000341346400015 PubMed ID: 24910002 ISSN: 0367-326X 电子 ISSN: 1873-6971 期刊信息 Impact Factor (影响因子): Journal Citation Reports® 其他信息 IDS 号: AO4YD Web of Science 核心合集中的 "引用的参考文献": 25 Web of Science 核心合集中的 "被引频次": 0 |
3楼2014-11-17 16:44:58