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作者: Zhang B, Feng X, Wang J, Xu X, Lin N, Liu H. 文题: Combined antitumor effect of Ad-bFGF-siRNA and Ad-Vpr on the growth of xenograft glioma in nude mouse model. 期刊名,年份,卷(期),起止页码: Pathol Oncol Res. 2011 Jun;17(2):237-42. 全文链接: http://dx.doi.org/10.1007/s12253-010-9303-5 数据库名称: springer 收录信息: 求助 SCI 收录信息 求助被引次数 |
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baiyuefei
版主 (文学泰斗)
风雪
- LS-EPI: 1647
- 应助: 4642 (副教授)
- 贵宾: 46.969
- 金币: 658104
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【答案】应助回帖
★ ★ ★ ★ ★
感谢参与，应助指数 +1
eveb: 金币+5, ★★★★★最佳答案, thank 2014-11-13 12:27:03
jssxh: LS-EPI+1, 谢谢参与，请继续关注本版块 2014-11-13 14:59:39
感谢参与，应助指数 +1
eveb: 金币+5, ★★★★★最佳答案, thank 2014-11-13 12:27:03
jssxh: LS-EPI+1, 谢谢参与，请继续关注本版块 2014-11-13 14:59:39
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Combined Antitumor Effect of Ad-bFGF-siRNA and Ad-Vpr on the Growth of Xenograft Glioma in Nude Mouse Model 作者:Zhang, B (Zhang, Biao)[ 2 ] ; Feng, XQ (Feng, Xuequan)[ 3 ] ; Wang, JH (Wang, Jinhuan)[ 1 ] ; Xu, XN (Xu, Xinnu)[ 4 ] ; Lin, N (Lin, Na)[ 4 ] ; Liu, HS (Liu, Hongsheng)[ 4 ] PATHOLOGY & ONCOLOGY RESEARCH 卷: 17 期: 2 页: 237-242 DOI: 10.1007/s12253-010-9303-5 出版年: JUN 2011 查看期刊信息 摘要 Basic fibroblast growth factor (bFGF) has been demonstrated to correlate with glioma grade and clinical outcome and has established its possible usefulness as a target for glioma therapy. Vpr has been described as an antitumor agent and displays a potent antitumor nature. Here, we try to investigate whether a combined treatment with bFGF-siRNA and Vpr gene would have a enhanced effectiveness on glioma in vitro and in vivo.After treatments with only Ad-bFGF-siRNA, only Ad-Vpr, and a combination of both, we assessed the changes in cell proliferation, cell cycle, and apoptosis in vitro by the methods of MTT, PI and FITC-AnnexinV double staining, respevtively. In addition, we also evaluated the combined effect of bFGF-siRNA and Vpr gene therapy on glioma in vivo using xenograft glioma models in nude mice. Combined Ad-bFGF-siRNA and Ad-Vpr treatment was more better successful in inhibiting cell proliferation in comparison with treatments of either Ad-bFGF-siRNA or Ad-Vpr alone. Treatment of Ad-Vpr alone or a treatment of a combination of Ad-bFGF-siRNA and Ad-Vpr induced the G2/M cell cycle arrest and apoptosis; however, combined treatment was more effective than the Ad-Vpr treatment alone. Although each single treatment can slow the growth of xenograft glioma, the combined treatment with Ad-bFGF-siRNA and Ad-Vpr was better than either the Ad-bFGF-siRNA or Ad-Vpr treatment alone. Our results suggest that the combination therapy with bFGF-siRNA and Vpr gene can achieve a enhanced activity of anti-glioma, supporting the idea that the combination of these two antitumor agents could open new perspectives in glioma therapy. 关键词 作者关键词:siRNA; bFGF; Vpr; Adenoviral vector KeyWords Plus:IN-VIVO ELECTROPORATION; HIV-1 VPR; NUCLEAR ACCUMULATION; CELLS; GLIOBLASTOMA; INHIBITION; CASPASE-9; RECEPTOR; PLASMID; TUMORS 作者信息 通讯作者地址: Wang, JH (通讯作者) Tianjin Huan Hu Hosp, Dept Neurosurg, 122 Qixiangtai Rd, Tianjin 300060, Peoples R China. 地址: [ 1 ] Tianjin Huan Hu Hosp, Dept Neurosurg, Tianjin 300060, Peoples R China [ 2 ] Tianjin Huan Hu Hosp, Clin Lab, Tianjin 300060, Peoples R China [ 3 ] Tianjin First Ctr Hosp, Dept Neurosurg, Tianjin 300192, Peoples R China [ 4 ] Tianjin First Ctr Hosp, Key Lab Crit Care Med, Minist Hlth, Tianjin 300192, Peoples R China 电子邮件地址:wangjinhuanfch@yahoo.com.cn 基金资助致谢 基金资助机构 授权号 National Natural Sciences Foundation of China 30672158 查看基金资助信息 出版商 SPRINGER, VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS 类别 / 分类 研究方向:Oncology; Pathology Web of Science 类别:Oncology; Pathology 文献信息 文献类型:Article 语种:English 入藏号: WOS:000290587300007 PubMed ID: 20848251 ISSN: 1219-4956 期刊信息 Impact Factor (影响因子): Journal Citation Reports® 其他信息 IDS 号: 763VH Web of Science 核心合集中的 "引用的参考文献": 20 Web of Science 核心合集中的 "被引频次": 5 引文网络 5 被引频次 20 引用的参考文献 查看 Related Records 查看引证关系图 创建引文跟踪 (数据来自 Web of ScienceTM 核心合集) 全部被引频次计数 5 / 所有数据库 5 / Web of Science 核心合集 1 / BIOSIS Citation Index 0 / 中国科学引文数据库 0 / Data Citation Index 0 / SciELO Citation Index 最近的引文 Zhang, S. HIV-1 viral protein R downregulates Ebp1 and stabilizes p53 in glioblastoma U87MG cells. CLINICAL & TRANSLATIONAL ONCOLOGY, MAR 2014. 查看全部 此记录来自: Web of ScienceTM 核心合集 建议修正 如果希望提高此记录中数据的质量，请提供修正建议。 |
2楼2014-11-13 12:21:57
baiyuefei
版主 (文学泰斗)
风雪
- LS-EPI: 1647
- 应助: 4642 (副教授)
- 贵宾: 46.969
- 金币: 658104
- 散金: 11616
- 红花: 995
- 沙发: 81
- 帖子: 69424
- 在线: 13328.3小时
- 虫号: 676696
- 注册: 2008-12-18
- 性别: GG
- 专业: 合成药物化学
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3楼2014-11-13 12:22:08
baiyuefei
版主 (文学泰斗)
风雪
- LS-EPI: 1647
- 应助: 4642 (副教授)
- 贵宾: 46.969
- 金币: 658104
- 散金: 11616
- 红花: 995
- 沙发: 81
- 帖子: 69424
- 在线: 13328.3小时
- 虫号: 676696
- 注册: 2008-12-18
- 性别: GG
- 专业: 合成药物化学
- 管辖: 有机交流
4楼2014-11-13 12:22:41
