| 查看: 328 | 回复: 0 | |||
[交流]
在宫颈癌患者血浆中HPV DNA
|
|
Human papillomavirus (HPV) is a crucial etiological factor for cervical cancer (CC) development. From a diagnostic view-point, the consistent presence of HPV in CC allows the viral DNA to be used as a genetic marker. The aims of this study were to evaluate the presence, physical status and clinical significant of HPV DNA in circulation of CC patients. Whereas 6 out of 50 (12%) HPV positive CC patients revealed plasma HPV DNA, it was detected in none of 20 normal controls or 13 HPV negative CC cases. The plasma DNA exhibited an HPV type identical to the HPV in the primary tumors and the DNA from both sources was integrated into host genome. Interestingly, several findings suggested an association between plasma HPV DNA and metastasis. First, three of the HPV DNA positive cases were CC patients with clinical stage IVB or recurrence with distance metastases (P = 0.001, RR = 15.67). Second, the amount of plasma HPV DNA from metastatic patients to be three times more than three other patients without metastases. Finally, the later cases had tendency to develop recurrence distant metastases within one year after complete treatment when compared with other HPV associated CC patients with the same stage but without the present of plasma HPV DNA. provide：www.tianyuan520.com |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : 1471-2407-1-2.pdf
2014-09-30 15:56:24, 400.78 K
» 猜你喜欢
挪威海洋神经生物招聘PHD博士(中级工资水平)，不需要走CSC
已经有2人回复
-
为自己的青基祈福得中，同时祝福大家课题高中！
已经有32人回复
-
法医学论文润色/翻译怎么收费?
已经有108人回复
-
求购通用试剂盒
已经有0人回复
-
求购通用试剂盒
已经有0人回复
-
作为共同作者在Nature Review Neurology上发表的疾病诊疗指南能作为代表性性论著吗
已经有5人回复
-
推荐核心期刊或者sci期刊
已经有2人回复
-
out for review 的日期更换了几次
已经有1人回复
-
案例汇报书写case report
已经有6人回复
-
视神经挤压损伤模型ONC小鼠实验相关
已经有2人回复
-
如果明天放榜，一般国合几点能查到？
已经有17人回复