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songmingxia铁杆木虫 (小有名气)
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| Xian-Qing Deng, zheng-Qi Dong, Ming-Xia Song, Bing Shu, Shi-Ben Wang, and Zhe-Shan Quan. Synthesis and Anticonvulsant Activities of Some Triazolothiadiazole Derivatives. ARCH PHARM, 2012, 345: 565–573. |
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baiyuefei
版主 (文学泰斗)
风雪
- LS-EPI: 1647
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【答案】应助回帖
★ ★
songmingxia: 金币+2, ★★★很有帮助, 谢谢啦 2014-09-20 12:15:32
songmingxia: 金币+2, ★★★很有帮助, 谢谢啦 2014-09-20 12:15:32
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Synthesis and Anticonvulsant Activities of Some Triazolothiadiazole Derivatives 作者  eng, XQ (Deng, Xian-Qing)[ 1 ] ; Dong, ZQ (Dong, Zheng-Qi)[ 2,3 ] ; Song, MX (Song, Ming-Xia)[ 1 ] ; Shu, B (Shu, Bing)[ 1 ] ; Wang, SB (Wang, Shi-Ben)[ 1 ] ; Quan, ZS (Quan, Zhe-Shan)[ 1 ] ARCHIV DER PHARMAZIE 卷: 345 期: 7 页: 565-573 DOI: 10.1002/ardp.201100326 出版年: JUL 2012 查看期刊信息 摘要 The present study describes the synthesis and anticonvulsant activity evaluation of 6-substituted-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives (4a4x) and their partially dehydrogenated products 5,6-dihydro-6-substituted-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives (5a5n). The bioevaluation demonstrated that most compounds in the series of 4a4x exhibited potent anticonvulsant activity in the maximal electroshock test. Among which, 6-(4-chlorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (4h) emerged as the most promising candidate on the basis of its favorable ED50 value of 23.7?mg/kg and PI value of 10.8. In addition, the potency of compound 4h against seizures induced by pentylenetetrazole, 3-mercaptopropionic acid, and bicuculline in the chemical-induced seizure tests suggested that compound 4h displayed broad-spectrum activity in several models, and it may exert its anticonvulsant activity through affecting the GABAergic system. 关键词 作者关键词:Anticonvulsant; Maximal electroshock; Pentylenetetrazole; Synthesis; Triazolothiadiazole KeyWords Plus:ANTIEPILEPTIC DRUGS; ANTI-HIV; EPILEPSY; GABA; ANTAGONISM; SEIZURES; ANALOGS 作者信息 通讯作者地址: Quan, ZS (通讯作者) Yanbian Univ, Coll Pharm, 977 Pk Rd, Yanji 133002, Jilin, Peoples R China. 地址: [ 1 ] Yanbian Univ, Coll Pharm, Yanji 133002, Jilin, Peoples R China [ 2 ] Peking Union Med Coll, Beijing 100021, Peoples R China [ 3 ] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100730, Peoples R China 电子邮件地址:zsquan@ybu.edu.cn 基金资助致谢 基金资助机构 授权号 National Natural Science Foundation of China 81160382 查看基金资助信息 出版商 WILEY-V C H VERLAG GMBH, BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY 类别 / 分类 研究方向  harmacology & Pharmacy; ChemistryWeb of Science 类别:Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy 文献信息 文献类型:Article 语种:English 入藏号: WOS:000305986000008 ISSN: 0365-6233 期刊信息 Impact Factor (影响因子): Journal Citation Reports® 其他信息 IDS 号: 968MO Web of Science 核心合集中的 "引用的参考文献": 29 Web of Science 核心合集中的 "被引频次": 6 化合物 1 至 10 |
3楼2014-09-20 12:07:36
baiyuefei
版主 (文学泰斗)
风雪
- LS-EPI: 1647
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【答案】应助回帖
★ ★ ★ ★
感谢参与，应助指数 +1
songmingxia: 金币+4, ★★★★★最佳答案, 非常感谢！！！ 2014-09-20 12:14:56
oven1986: LS-EPI+1, 感谢应助！ 2014-09-21 00:36:28
感谢参与，应助指数 +1
songmingxia: 金币+4, ★★★★★最佳答案, 非常感谢！！！ 2014-09-20 12:14:56
oven1986: LS-EPI+1, 感谢应助！ 2014-09-21 00:36:28
|
被引频次: 6 https://apps.webofknowledge.com/ ... c-8f45-2e9ed8ee98dc 1. 1,3,4-Thiadiazole: Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials Chemistry 作者: Hu, Yang; Li, Cui-Yun; Wang, Xiao-Ming; 等. CHEMICAL REVIEWS 卷: 114 期: 10 页: 5572-5610 出版年: MAY 28 2014 出版商处的全文 被引频次: 0 (来自 Web of Science 的核心合集) 2. Synthesis and evaluation of the anticonvulsant activity of 8-alkoxy-4,5-dihydrobenzo[1,2,4]triazolo[4,3-d][1,4]thiazepine derivatives 作者: Deng, Xian-Qing; Song, Ming-Xia; Wang, Shi-Ben; 等. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 卷: 29 期: 2 页: 272-280 出版年: APR 2014 出版商处的全文 查看摘要 被引频次: 0 (来自 Web of Science 的核心合集) 3. N-(5-Mercapto-1,3,4-Thiadiazol-2-yl)-2-Phenylacetamide Derivatives: Synthesis and In-vitro Cytotoxicity Evaluation as Potential Anticancer Agents 作者: Mohammadi-Farani, Ahmad; Heidarian, Neda; Aliabadi, Alireza IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH 卷: 13 期: 2 页: 487-492 出版年: SPR 2014 查看摘要 被引频次: 0 (来自 Web of Science 的核心合集) 4. Discovery of 2-Phenyl-N-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)acetamide Derivatives as Apoptosis Inducers via the Caspase Pathway with Potential Anticancer Activity 作者: Hosseinzadeh, Leila; Khorand, Amanc; Aliabadi, Alireza ARCHIV DER PHARMAZIE 卷: 346 期: 11 页: 812-818 出版年: NOV 2013 出版商处的全文 查看摘要 被引频次: 1 (来自 Web of Science 的核心合集) 5. Design, synthesis and antidepressant activity evaluation 2'-hydroxy-4',6'-diisoprenyloxychalcone derivatives 作者: Guan, Li-Ping; Zhao, Dong-Hai; Chang, Yue; 等. MEDICINAL CHEMISTRY RESEARCH 卷: 22 期: 11 页: 5218-5226 出版年: NOV 2013 出版商处的全文 查看摘要 被引频次: 2 (来自 Web of Science 的核心合集) 6. Synthesis and antimicrobial activity of new 1,3,4-thiadiazoles containing oxadiazole, thiadiazole and triazole nuclei 作者: Maddila, Suresh; Jonnalagadda, Sreekanth B. PHARMACEUTICAL CHEMISTRY JOURNAL 卷: 46 期: 11 页: 661-666 出版年: FEB 2013 出版商处的全文 查看摘要 |
2楼2014-09-20 12:07:10
baiyuefei
版主 (文学泰斗)
风雪
- LS-EPI: 1647
- 应助: 4642 (副教授)
- 贵宾: 46.969
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- 性别: GG
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- 管辖: 有机交流
4楼2014-09-20 12:07:46
