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【药理】求助大神翻译一段话，谢谢！
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DH-PS induced the secretions of multiple cytokines and chemokines in vivo In order to understand the immunological activities of DH-PS, we investigated the profiles of cytokines and chemokines induced by DH-PS in mice. BALB/c mice (n= 3 for DH-PS and phosphate buffered saline (PBS) group) were injected intraperitoneally (IP) with DH-PS (300 mg/mouse) in PBS or PBS only and the sera were collected at 0 (before injection), 2 and 18 hrs after the injection of DH-PS for the detection of cytokines and chemokines, which were quantified by Beadlyte Mouse 21-plex Cytokine Detection system and ELISA kits (for IL-1ra). Compared with PBS group shown in Figure 1, the increase of TNF-a, IL-12 p40, IL-6, IL-10 and RANTES were observed at 2 hrs, along with robust inductions of KC, MCP-1 and MIP-1b. An apparent increase in IL-1b at 2 hrs was noted but it did not reach statistical significance. These results suggested that DH-PS induced Th1 (IL-12 p40), Th2 (IL-6, IL-10), inflammatory cytokines (TNF-a) and chemokines (KC, RANTES, MCP-1, MIP-1b), which might further modulate the downstream activations of immune cells. Furthermore, an antiinflammatory molecule, IL-1ra, was increased from 465 to 4199 pg/ml (,9 folds of PBS control group) at 2 hrs. This indicated that the amounts of IL-1ra induced were 10 folds more than IL-1b (increased from 144 to 397 pg/ml, ,1.6 folds of PBS control group), suggesting that DH-PS-induced IL-1ra might override the activity induced by IL-1b.  1.jpg |
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