| 查看: 2738 | 回复: 6 | |||
hupheng铁杆木虫 (著名写手)
|
[交流]
Postdoctoral Position at the University of Houston College of Pharmacy 已有3人参与
|
|
Postdoctoral Position at the University of Houston College of Pharmacy A post-doctoral position is available at the University of Houston, College of Pharmacy, Department of Pharmacological and Pharmaceutical Sciences in the field of medicinal and organic chemistry. The successful candidate will be responsible for the design, synthesis and characterization of compounds to be used in structure-activity relationship and optimization studies with biology collaborators. The ideal candidate should have strong synthetic organic chemistry skills, including compound purification and characterization. They should also be highly motivated, have good work ethic, excellent communication skills, and be able to work independently and potentially supervise undergraduate students. If you are interested, please send your CV and a research summary to chem77004@yahoo.com. http://www.uh.edu/pharmacy/directory-home/pps-faculty/greg-cuny/ Selected Publication: Gorla SK, Kavitha M, Zhang M, Chin JE, Liu X, Striepen B, Makowska-Grzyska M, Kim Y, Joachimiak A, Hedstrom L, Cuny GD. Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem. 2013 May 23;56(10):4028-43. doi: 10.1021/jm400241j. Epub 2013 May 13. PMID: 23668331 Johnson CR, Gorla SK, Kavitha M, Zhang M, Liu X, Striepen B, Mead JR, Cuny GD, Hedstrom L. Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1004-7. doi: 10.1016/j.bmcl.2012.12.037. Epub 2012 Dec 27. PMID: 23324406 Gorla SK, Kavitha M, Zhang M, Liu X, Sharling L, Gollapalli DR, Striepen B, Hedstrom L, Cuny GD. Selective and potent urea inhibitors of cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem. 2012 Sep 13;55(17):7759-71. doi: 10.1021/jm3007917. Epub 2012 Sep 5. PMID: 22950983 Hellal, M.; Singh, S.; Cuny, G.D. Synthesis of tetracyclic indoles via intramolecular α-arylation of ketones. J. Org. Chem. 2012, 77, 4123 – 4130. Kirubakaran, S.; Gorla, S.K.; Sharling, L.; Zhang, M.; Liu, X.; Ray, S.S.; MacPherson, I.S.; Striepen, B.; Hedstrom, L.; Cuny, G.D. Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH. Bioorg. Med. Chem. Lett. 2012, 22, 1985 – 1988. Cuny, G.D.; Ulyanova, N.P.; Patnaik, D.; Liu, J.-F.; Lin, X.; Auerbach, K.; Ray, S.S.; Xian, J.; Glicksman, M.A.; Stein, R.L.; Higgins, J.M.G. Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors. Bioorg. Med. Chem. Lett. 2012, 22, 2015 – 2019. Hellal, M.; Singh, S.; Cuny, G.D. Monoligated Pd(0)-catalyzed intramolecular ortho- and para-arylation of phenols for the synthesis of aporphine alkaloids. Synthesis of (-)-lirinine. Tetrahedron 2012, 68, 1674 – 1681. Laha, J.K.; Cuny, G.D. Synthesis of fused imidazoles, pyrroles and indoles with a defined stereocenter alpha to nitrogen utilizing Mitsunobu alkylation followed by palladium-catalyzed cyclization. J. Org. Chem. 2011, 8477 – 8482. Hellal, M.; Cuny, G.D. Microwave assisted copper-free Sonogashira coupling/5-exo-dig cycloisomerization domino reaction: access to 3-(phenylmethylene)isoindolin-1-ones and related heterocycles. Tetrahedron Lett. 2011, 52, 5508 – 5511. Xing, X.; Chang, L.-C.; Kong, Q.; Colton, C.K.; Lai, L.; Glicksman, M.A.; Li, C.-L.G.; Cuny, G.D. Structureactivity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg. Med. Chem. Lett. 2011, 21, 5774 – 5777. Laha, J.K.; Barolo, S.M.; Rossi, R.A.; Cuny, G.D. Synthesis of carbolines by photo-stimulated cyclization of anilinohalopyridines. J. Org. Chem. 2011, 76, 6421 – 6425. Laha, J.K.; Zhang, X.; Qiao, L.; Liu, M.; Chatterjee, S.; Robinson, S.; Kosik, K.S.; Cuny, G.D. Structureactivity relationship study of 2,4-diaminothiazoles as cdk5/p25 kinase inhibitors. Bioorg. Med. Chem. Lett. 2011, 21, 2098 - 2101. Shishova, E.Y.; Stoll, J.M.; Ersoy, B.A.; Shrestha, S.; Scapa, E.F.; Li, Y.; Niepel, M.W.; Su, Y.; Jelicks, L.A.; Stahl, G.L.; Glicksman, M.; Gutierrez-Juarez, R.; Cuny, G.D.; Cohen, D.E. Genetic Ablation or Chemical Inhibition of Phosphatidylcholine Transfer Protein Attenuates Diet-Induced Hepatic Glucose Production Hepatology 2011, 54, 664 – 674. Steinbicker, A.U.; Sachidanandan, C.; Vonner, A.J.; Yusuf, R.Z.; Deng, D.Y.; Lai, C.S.; Rauwerdink, K.M.; Winn, J.C.; Saez, B.; Cook, C.M.; Szekely, B.A.; Roy, C.N.; Seehra, J.S.; Cuny, G.D.; Scadden, D.T.; Peterson, R.T.; Bloch, K.D.; Yu, P.B. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood 2011, 117, 4915 – 4923. Zeng, X.; Sigoillot, F.; Gaur, S.; Choi, S.; Pfaff, K.L.; Oh, D.-C.; Hathaway, N.; Dimova, N.; Cuny, G.D.; King, R.W. Pharmacologic Inhibition of the Anaphase-Promoting Complex Induces A Spindle Checkpoint- Dependent Mitotic Arrest in the Absence of Spindle Damage. Cancer Cell 2010, 18, 382 – 395. Hellal, M.; Cuny, G.D. Synthesis of the indolizino[7,6-c] quinoline alkaloid isaindigotidione. Org. Lett. 2010, 12, 4628 – 4631. Cuny, G.D.; Robin, M.; Ulyanova, N.P.; Patnaik, D.; Pique, V.; Casano, G.; Liu, J.-F.; Lin, X.; Xian, J.; Glicksman, M.A.; Stein, R.L.; Higgins, J.M.G. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg. Med. Chem. Lett. 2010, 3491 – 3494. Hellal, M.; Cuny, G.D. Intramolecular aldol reaction of N-acylated (2-aminophenyl)--oxoacetic acids: Rapid access to tri- and tetracyclic 1,2-dihydroquinolin-2(1H)-ones. J. Org. Chem 2010, 75, 3465 – 3468. Liu, M.; Poulose, S.; Schuman, E.; Zaitsev, A.D.; Dobson, B.; Auerbach, K.; Seyb, K.; Cuny, G.D.; Glicksman, M.A.; Stein, R.L.; Yue, Z. Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2 – discovery of LRRK2 inhibitors. Anal. Biochem. 2010, 404, 186 – 192. Leissring, M.A.; Malito, E.; Hedouin, S.; Reinstatler, L.; Sahara, T.; Abdul-Hay, S.O.; Choudhry, S.; Maharvy, G.M.; Fauq, A.H.; Huzarska, M.; May, P.S.; Choi, S.; Logan, T.E.; Turk, B.E.; Cantley, L.C.; Manolopoulou, M.; Tang, W.-J.; Stein, R.L.; Cuny, G.D.; Selkoe, D.J. Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. PLoS One 2010, 5, e10504. Nowak, R.J.; Cuny, G.D.; Choi, S.; Lansbury, P.T.; Ray, S.S. Improving binding specificity of pharmacological chaperones that target mutant SOD-1 linked to familial ALS using computational methods. J. Med. Chem. 2010, 53, 2709 – 2718. Lee, K.; Campbell, J.; Swoboda, J.G.; Cuny, G.D.; Walker, S. Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus. Bioorg. Med. Chem. Lett. 2010, 20, 1767 – 1770. Ouertatani-Sakouhi, H.; Liu, M.; El-Turk, F.; Cuny, G.D.; Glicksman, M.A.; Lashuel, H.A. Kinetic-based highthroughput screening assay to discover novel classes of macrophage migration inhibitory factor inhibitors. J. Biomol. Screen. 2010, 15, 347 – 358. Colton, C.K.; Kong, Q.; Lai, L.; Zhu, M.X.; Seyb, K.I.; Cuny, G.D.; Xian, J.; Glicksman, M.A.; Lin, C.-L. G. Identification of translational activators of glial glutamate transporter EAAT2 through a cell-based highthroughput screening: An approach for preventing excitotoxicity. J. Biomol. Screen. 2010, 15, 653 - 662. Cotten, J.F.; Forman, S.A.; Laha, J.K.; Cuny, G.D.; Husain, S.S.; Miller, K.W.; Nguyen, H.H.; Kelly, E.W.; Stewart, D.; Liu, A.; Raines, D.E. Carboetomidate: A pyrrole analogue of etomidate that does not suppress adrenocortical function. Anesthesiology 2010, 112, 637 – 644. Rosenbaum, D.M; Degterev, A.; David, J; Rosenbaum, P.S.; Roth, S.; Grotta, J.C.; Cuny, G.D.; Yuan, J; Savitz, S.I. Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J. Neurosci. Res. 2010, 88, 1569 – 1576. MacPherson, I.S.; Kirubakaran, S.; Gorla, S.K.; Riera, T.V.; D'Aquino, A.J.; Zhang, M.; Cuny, G.D.; Hedstrom, L. The structural basis of Cryptosporidium-specific IMP dehydrogenase inhibitor selectivity. J. Am. Chem. Soc. 2010, 132, 1230 – 1231. Cuny, G.D. Kinase inhibitors as potential therapeutics for acute and chronic neurodegenerative conditions. Curr. Pharm. Design 2009, 15, 3919 – 3939. Qiao, L.; Choi, S.; Case, A.; Gainer, T.G.; Seyb, K.; Glicksman, M.A.; Lo, D.C.; Stein, R.L.; Cuny, G.D. Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors. Bioorg. Med. Chem. Lett. 2009, 6122 – 6126. Maurya, S.K.; Gollapalli, D.R.; Kirubakaran, S.; Zhang, M.; Johnson, C.R.; Benjamin, N.N.; Hedstrom, L.; Cuny, G.D. Triazole inhibitors of Cryptosporidium parvum inosine 5’-monophosphate dehydrogenase. J. Med. Chem. 2009, 52, 4623 - 4630. Cabrol, C.; Huzarska, M.; Dinolfo, C.; Rodriguez, M.C.; Reinstatler, L.; Ni, J.; Yeh, L.-A.; Cuny, G.D.; Stein, R.L.; Selkoe, D.J.; Leissring, M.A. Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening. PLoS One 2009, 4, e5274. Call, M.J.; Xing, X.; Cuny, G.D., Seth, N.P.; Altmann, D.; Fugger, L.; Krogsgaard, M.; Stein, R.L.; Wucherpfennig, K.W. In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange. J Immunol. 2009, 182, 6342 – 6352. Laha, J.K.; Petrou, P.; Cuny, G.D. One-pot synthesis of alpha-carbolines via sequential palladium-catalyzed aryl amination and intramolecular arylation. J. Org. Chem. 2009, 74, 3152 – 3155. Wu, J.; Xing, X; Cuny, G.D. Synthesis of substituted imidazo[1,5-a]pyrimidines, 1H-pyrrolo[2,3-b]pyridines and 3-methyl-3H-imidazo[4,5-b]pyridines. Lett. Org. Chem. 2009, 6, 203 – 207. Cuny, G.D. A new class of UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitors for the treatment of Gram-negative infections: PCT application WO 2008027466. Expert Opin. Ther. Patents 2009, 19, 893 – 899. Yu, P.B.; Deng, D.Y.; Lai, C.S.; Hong, C.C.; Cuny, G.D.; Bouxsein, M.L.; Peterson, R.T.; Katagiri, T.; Fukuda, T.; Mishina, Y.; Bloch, K.D. BMP type I receptor inhibition reduces heterotopic ossification. Nat. Med. 2008, 14, 1363 – 1369. Laha, J.K.; Cuny, G.D. Synthesis of tetrazolo[1,5-a]pyridines utilizing trimethylsilyl azide and tetrabutylammonium fluoride hydrate. Synthesis, 2008, 4002 – 4006. |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : postdoc_wanted.docx
2014-09-12 03:03:29, 17.31 K
» 猜你喜欢
材料与化工304求B区调剂
已经有7人回复
-
0703化学336分求调剂
已经有4人回复
-
[复试调剂]西南科技大学国防/材料导师推荐
已经有6人回复
-
化学工程321分求调剂
已经有12人回复
-
211本，11408一志愿中科院277分，曾在中科院自动化所实习
已经有4人回复
-
材料专硕326求调剂
已经有5人回复
-
东南大学364求调剂
已经有5人回复
-
国自科面上基金字体
已经有7人回复
-
药学383 求调剂
已经有4人回复
-
286求调剂
已经有5人回复
» 本主题相关价值贴推荐，对您同样有帮助:
- Postdoctoral Position (Computer Vision, University of Nebraska-Lincoln, USA)
已经有8人回复
- postdoctoral position at the University of Pennsylvania
已经有56人回复
- Open postdoctoral position in first-principles materials simulation at UCSD
已经有3人回复
- New postdoctoral position in Energy Materials available in Australia
已经有10人回复
- Postdoctoral Position in Organic Chemistry
已经有7人回复
- Postdoctoral position at Nanyang Technological University in Singapore
已经有1人回复
- Postdoctoral position in theoretical physics/biophysics (France)
已经有0人回复
- Postdoctoral position the Goethe-University of Frankfurt
已经有3人回复
- postdoctoral position in theoretical chemistry
已经有2人回复
- Postdoctoral Research Position at University of Washington in Seattle
已经有6人回复
- Post-PhD position of university of Cambridge
已经有6人回复
- Postdoctoral position in astroparticle physics at the University of Zurich
已经有0人回复
- POSTDOCTORAL POSITION, National Taiwan University
已经有9人回复
- Thank you for your application for a position at the University of Canterbury
已经有5人回复
- Postdoctoral Position
已经有8人回复
- Postdoctoral position in California
已经有1人回复
- Postdoctoral Position at the University of British Columbia
已经有2人回复
- Postdoctoral Position at Colorado State University
已经有2人回复
jixufendou
银虫 (小有名气)
- 应助: 12 (小学生)
- 金币: 420.1
- 红花: 1
- 帖子: 205
- 在线: 77.4小时
- 虫号: 1841823
- 注册: 2012-05-31
- 专业: 应用有机化学
2楼2014-09-12 08:56:41
 本帖仅楼主可见 |
3楼2014-09-13 08:50:00
hupheng
铁杆木虫 (著名写手)
- 应助: 83 (初中生)
- 金币: 5952.2
- 散金: 1
- 红花: 8
- 帖子: 1392
- 在线: 293.3小时
- 虫号: 103353
- 注册: 2005-11-14
- 性别: GG
- 专业: 金属有机化学
4楼2014-09-17 01:28:11
hupheng
铁杆木虫 (著名写手)
- 应助: 83 (初中生)
- 金币: 5952.2
- 散金: 1
- 红花: 8
- 帖子: 1392
- 在线: 293.3小时
- 虫号: 103353
- 注册: 2005-11-14
- 性别: GG
- 专业: 金属有机化学
5楼2014-09-22 02:36:57
6楼2014-09-22 21:40:55
hupheng
铁杆木虫 (著名写手)
- 应助: 83 (初中生)
- 金币: 5952.2
- 散金: 1
- 红花: 8
- 帖子: 1392
- 在线: 293.3小时
- 虫号: 103353
- 注册: 2005-11-14
- 性别: GG
- 专业: 金属有机化学
7楼2014-09-25 02:37:12
