| ²é¿´: 2750 | »Ø¸´: 6 | |||
| µ±Ç°Ö»ÏÔʾÂú×ãÖ¸¶¨Ìõ¼þµÄ»ØÌû£¬µã»÷ÕâÀï²é¿´±¾»°ÌâµÄËùÓлØÌû | |||
huphengÌú¸Ëľ³æ (ÖøÃûдÊÖ)
|
[½»Á÷]
Postdoctoral Position at the University of Houston College of Pharmacy ÒÑÓÐ3È˲ÎÓë
|
||
|
Postdoctoral Position at the University of Houston College of Pharmacy A post-doctoral position is available at the University of Houston, College of Pharmacy, Department of Pharmacological and Pharmaceutical Sciences in the field of medicinal and organic chemistry. The successful candidate will be responsible for the design, synthesis and characterization of compounds to be used in structure-activity relationship and optimization studies with biology collaborators. The ideal candidate should have strong synthetic organic chemistry skills, including compound purification and characterization. They should also be highly motivated, have good work ethic, excellent communication skills, and be able to work independently and potentially supervise undergraduate students. If you are interested, please send your CV and a research summary to chem77004@yahoo.com. http://www.uh.edu/pharmacy/directory-home/pps-faculty/greg-cuny/ Selected Publication: Gorla SK, Kavitha M, Zhang M, Chin JE, Liu X, Striepen B, Makowska-Grzyska M, Kim Y, Joachimiak A, Hedstrom L, Cuny GD. Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem. 2013 May 23;56(10):4028-43. doi: 10.1021/jm400241j. Epub 2013 May 13. PMID: 23668331 Johnson CR, Gorla SK, Kavitha M, Zhang M, Liu X, Striepen B, Mead JR, Cuny GD, Hedstrom L. Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1004-7. doi: 10.1016/j.bmcl.2012.12.037. Epub 2012 Dec 27. PMID: 23324406 Gorla SK, Kavitha M, Zhang M, Liu X, Sharling L, Gollapalli DR, Striepen B, Hedstrom L, Cuny GD. Selective and potent urea inhibitors of cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem. 2012 Sep 13;55(17):7759-71. doi: 10.1021/jm3007917. Epub 2012 Sep 5. PMID: 22950983 Hellal, M.; Singh, S.; Cuny, G.D. Synthesis of tetracyclic indoles via intramolecular ¦Á-arylation of ketones. J. Org. Chem. 2012, 77, 4123 ¨C 4130. Kirubakaran, S.; Gorla, S.K.; Sharling, L.; Zhang, M.; Liu, X.; Ray, S.S.; MacPherson, I.S.; Striepen, B.; Hedstrom, L.; Cuny, G.D. Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH. Bioorg. Med. Chem. Lett. 2012, 22, 1985 ¨C 1988. Cuny, G.D.; Ulyanova, N.P.; Patnaik, D.; Liu, J.-F.; Lin, X.; Auerbach, K.; Ray, S.S.; Xian, J.; Glicksman, M.A.; Stein, R.L.; Higgins, J.M.G. Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors. Bioorg. Med. Chem. Lett. 2012, 22, 2015 ¨C 2019. Hellal, M.; Singh, S.; Cuny, G.D. Monoligated Pd(0)-catalyzed intramolecular ortho- and para-arylation of phenols for the synthesis of aporphine alkaloids. Synthesis of (-)-lirinine. Tetrahedron 2012, 68, 1674 ¨C 1681. Laha, J.K.; Cuny, G.D. Synthesis of fused imidazoles, pyrroles and indoles with a defined stereocenter alpha to nitrogen utilizing Mitsunobu alkylation followed by palladium-catalyzed cyclization. J. Org. Chem. 2011, 8477 ¨C 8482. Hellal, M.; Cuny, G.D. Microwave assisted copper-free Sonogashira coupling/5-exo-dig cycloisomerization domino reaction: access to 3-(phenylmethylene)isoindolin-1-ones and related heterocycles. Tetrahedron Lett. 2011, 52, 5508 ¨C 5511. Xing, X.; Chang, L.-C.; Kong, Q.; Colton, C.K.; Lai, L.; Glicksman, M.A.; Li, C.-L.G.; Cuny, G.D. Structureactivity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg. Med. Chem. Lett. 2011, 21, 5774 ¨C 5777. Laha, J.K.; Barolo, S.M.; Rossi, R.A.; Cuny, G.D. Synthesis of carbolines by photo-stimulated cyclization of anilinohalopyridines. J. Org. Chem. 2011, 76, 6421 ¨C 6425. Laha, J.K.; Zhang, X.; Qiao, L.; Liu, M.; Chatterjee, S.; Robinson, S.; Kosik, K.S.; Cuny, G.D. Structureactivity relationship study of 2,4-diaminothiazoles as cdk5/p25 kinase inhibitors. Bioorg. Med. Chem. Lett. 2011, 21, 2098 - 2101. Shishova, E.Y.; Stoll, J.M.; Ersoy, B.A.; Shrestha, S.; Scapa, E.F.; Li, Y.; Niepel, M.W.; Su, Y.; Jelicks, L.A.; Stahl, G.L.; Glicksman, M.; Gutierrez-Juarez, R.; Cuny, G.D.; Cohen, D.E. Genetic Ablation or Chemical Inhibition of Phosphatidylcholine Transfer Protein Attenuates Diet-Induced Hepatic Glucose Production Hepatology 2011, 54, 664 ¨C 674. Steinbicker, A.U.; Sachidanandan, C.; Vonner, A.J.; Yusuf, R.Z.; Deng, D.Y.; Lai, C.S.; Rauwerdink, K.M.; Winn, J.C.; Saez, B.; Cook, C.M.; Szekely, B.A.; Roy, C.N.; Seehra, J.S.; Cuny, G.D.; Scadden, D.T.; Peterson, R.T.; Bloch, K.D.; Yu, P.B. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood 2011, 117, 4915 ¨C 4923. Zeng, X.; Sigoillot, F.; Gaur, S.; Choi, S.; Pfaff, K.L.; Oh, D.-C.; Hathaway, N.; Dimova, N.; Cuny, G.D.; King, R.W. Pharmacologic Inhibition of the Anaphase-Promoting Complex Induces A Spindle Checkpoint- Dependent Mitotic Arrest in the Absence of Spindle Damage. Cancer Cell 2010, 18, 382 ¨C 395. Hellal, M.; Cuny, G.D. Synthesis of the indolizino[7,6-c] quinoline alkaloid isaindigotidione. Org. Lett. 2010, 12, 4628 ¨C 4631. Cuny, G.D.; Robin, M.; Ulyanova, N.P.; Patnaik, D.; Pique, V.; Casano, G.; Liu, J.-F.; Lin, X.; Xian, J.; Glicksman, M.A.; Stein, R.L.; Higgins, J.M.G. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg. Med. Chem. Lett. 2010, 3491 ¨C 3494. Hellal, M.; Cuny, G.D. Intramolecular aldol reaction of N-acylated (2-aminophenyl)--oxoacetic acids: Rapid access to tri- and tetracyclic 1,2-dihydroquinolin-2(1H)-ones. J. Org. Chem 2010, 75, 3465 ¨C 3468. Liu, M.; Poulose, S.; Schuman, E.; Zaitsev, A.D.; Dobson, B.; Auerbach, K.; Seyb, K.; Cuny, G.D.; Glicksman, M.A.; Stein, R.L.; Yue, Z. Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2 ¨C discovery of LRRK2 inhibitors. Anal. Biochem. 2010, 404, 186 ¨C 192. Leissring, M.A.; Malito, E.; Hedouin, S.; Reinstatler, L.; Sahara, T.; Abdul-Hay, S.O.; Choudhry, S.; Maharvy, G.M.; Fauq, A.H.; Huzarska, M.; May, P.S.; Choi, S.; Logan, T.E.; Turk, B.E.; Cantley, L.C.; Manolopoulou, M.; Tang, W.-J.; Stein, R.L.; Cuny, G.D.; Selkoe, D.J. Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. PLoS One 2010, 5, e10504. Nowak, R.J.; Cuny, G.D.; Choi, S.; Lansbury, P.T.; Ray, S.S. Improving binding specificity of pharmacological chaperones that target mutant SOD-1 linked to familial ALS using computational methods. J. Med. Chem. 2010, 53, 2709 ¨C 2718. Lee, K.; Campbell, J.; Swoboda, J.G.; Cuny, G.D.; Walker, S. Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus. Bioorg. Med. Chem. Lett. 2010, 20, 1767 ¨C 1770. Ouertatani-Sakouhi, H.; Liu, M.; El-Turk, F.; Cuny, G.D.; Glicksman, M.A.; Lashuel, H.A. Kinetic-based highthroughput screening assay to discover novel classes of macrophage migration inhibitory factor inhibitors. J. Biomol. Screen. 2010, 15, 347 ¨C 358. Colton, C.K.; Kong, Q.; Lai, L.; Zhu, M.X.; Seyb, K.I.; Cuny, G.D.; Xian, J.; Glicksman, M.A.; Lin, C.-L. G. Identification of translational activators of glial glutamate transporter EAAT2 through a cell-based highthroughput screening: An approach for preventing excitotoxicity. J. Biomol. Screen. 2010, 15, 653 - 662. Cotten, J.F.; Forman, S.A.; Laha, J.K.; Cuny, G.D.; Husain, S.S.; Miller, K.W.; Nguyen, H.H.; Kelly, E.W.; Stewart, D.; Liu, A.; Raines, D.E. Carboetomidate: A pyrrole analogue of etomidate that does not suppress adrenocortical function. Anesthesiology 2010, 112, 637 ¨C 644. Rosenbaum, D.M; Degterev, A.; David, J; Rosenbaum, P.S.; Roth, S.; Grotta, J.C.; Cuny, G.D.; Yuan, J; Savitz, S.I. Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J. Neurosci. Res. 2010, 88, 1569 ¨C 1576. MacPherson, I.S.; Kirubakaran, S.; Gorla, S.K.; Riera, T.V.; D'Aquino, A.J.; Zhang, M.; Cuny, G.D.; Hedstrom, L. The structural basis of Cryptosporidium-specific IMP dehydrogenase inhibitor selectivity. J. Am. Chem. Soc. 2010, 132, 1230 ¨C 1231. Cuny, G.D. Kinase inhibitors as potential therapeutics for acute and chronic neurodegenerative conditions. Curr. Pharm. Design 2009, 15, 3919 ¨C 3939. Qiao, L.; Choi, S.; Case, A.; Gainer, T.G.; Seyb, K.; Glicksman, M.A.; Lo, D.C.; Stein, R.L.; Cuny, G.D. Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors. Bioorg. Med. Chem. Lett. 2009, 6122 ¨C 6126. Maurya, S.K.; Gollapalli, D.R.; Kirubakaran, S.; Zhang, M.; Johnson, C.R.; Benjamin, N.N.; Hedstrom, L.; Cuny, G.D. Triazole inhibitors of Cryptosporidium parvum inosine 5¡¯-monophosphate dehydrogenase. J. Med. Chem. 2009, 52, 4623 - 4630. Cabrol, C.; Huzarska, M.; Dinolfo, C.; Rodriguez, M.C.; Reinstatler, L.; Ni, J.; Yeh, L.-A.; Cuny, G.D.; Stein, R.L.; Selkoe, D.J.; Leissring, M.A. Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening. PLoS One 2009, 4, e5274. Call, M.J.; Xing, X.; Cuny, G.D., Seth, N.P.; Altmann, D.; Fugger, L.; Krogsgaard, M.; Stein, R.L.; Wucherpfennig, K.W. In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange. J Immunol. 2009, 182, 6342 ¨C 6352. Laha, J.K.; Petrou, P.; Cuny, G.D. One-pot synthesis of alpha-carbolines via sequential palladium-catalyzed aryl amination and intramolecular arylation. J. Org. Chem. 2009, 74, 3152 ¨C 3155. Wu, J.; Xing, X; Cuny, G.D. Synthesis of substituted imidazo[1,5-a]pyrimidines, 1H-pyrrolo[2,3-b]pyridines and 3-methyl-3H-imidazo[4,5-b]pyridines. Lett. Org. Chem. 2009, 6, 203 ¨C 207. Cuny, G.D. A new class of UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitors for the treatment of Gram-negative infections: PCT application WO 2008027466. Expert Opin. Ther. Patents 2009, 19, 893 ¨C 899. Yu, P.B.; Deng, D.Y.; Lai, C.S.; Hong, C.C.; Cuny, G.D.; Bouxsein, M.L.; Peterson, R.T.; Katagiri, T.; Fukuda, T.; Mishina, Y.; Bloch, K.D. BMP type I receptor inhibition reduces heterotopic ossification. Nat. Med. 2008, 14, 1363 ¨C 1369. Laha, J.K.; Cuny, G.D. Synthesis of tetrazolo[1,5-a]pyridines utilizing trimethylsilyl azide and tetrabutylammonium fluoride hydrate. Synthesis, 2008, 4002 ¨C 4006. |
» ±¾Ìû¸½¼þ×ÊÔ´Áбí
-
»¶Ó¼à¶½ºÍ·´À¡£ºÐ¡Ä¾³æ½öÌṩ½»Á÷ƽ̨£¬²»¶Ô¸ÃÄÚÈݸºÔð¡£
±¾ÄÚÈÝÓÉÓû§×ÔÖ÷·¢²¼£¬Èç¹ûÆäÄÚÈÝÉæ¼°µ½ÖªÊ¶²úȨÎÊÌ⣬ÆäÔðÈÎÔÚÓÚÓû§±¾ÈË£¬Èç¶Ô°æÈ¨ÓÐÒìÒ飬ÇëÁªÏµÓÊÏ䣺xiaomuchong@tal.com - ¸½¼þ 1 : postdoc_wanted.docx
2014-09-12 03:03:29, 17.31 K
» ²ÂÄãϲ»¶
2026Ä껪ÄÏʦ·¶´óѧ»¶Ó»¯Ñ§£¬»¯¹¤£¬ÉúÎÉúÒ½¹¤µÈרҵÓÅÐãѧ×Ó¼ÓÈ룡
ÒѾÓÐ5È˻ظ´
298Çóµ÷¼Á
ÒѾÓÐ3È˻ظ´
ÊýÒ»Ó¢Ò»271ר˶£¨085401£©Çóµ÷¼Á£¬¿É¿ç
ÒѾÓÐ8È˻ظ´
295Çóµ÷¼Á
ÒѾÓÐ4È˻ظ´
0856Çóµ÷¼Á
ÒѾÓÐ5È˻ظ´
²ÄÁÏѧ˶333Çóµ÷¼Á
ÒѾÓÐ10È˻ظ´
299Çóµ÷¼Á
ÒѾÓÐ6È˻ظ´
Ò»Ö¾Ô¸Ö£ÖÝ´óѧ£¬080500ѧ˶£¬×Ü·Ö317·ÖÇóµ÷¼Á
ÒѾÓÐ6È˻ظ´
289Çóµ÷¼Á
ÒѾÓÐ12È˻ظ´
070305¸ß·Ö×Ó»¯Ñ§ÓëÎïÀí 304·ÖÇóµ÷¼Á
ÒѾÓÐ6È˻ظ´
» ±¾Ö÷ÌâÏà¹Ø¼ÛÖµÌùÍÆ¼ö£¬¶ÔÄúͬÑùÓаïÖú:
Postdoctoral Position (Computer Vision, University of Nebraska-Lincoln, USA)
ÒѾÓÐ8È˻ظ´
postdoctoral position at the University of Pennsylvania
ÒѾÓÐ56È˻ظ´
Open postdoctoral position in first-principles materials simulation at UCSD
ÒѾÓÐ3È˻ظ´
New postdoctoral position in Energy Materials available in Australia
ÒѾÓÐ10È˻ظ´
Postdoctoral Position in Organic Chemistry
ÒѾÓÐ7È˻ظ´
Postdoctoral position at Nanyang Technological University in Singapore
ÒѾÓÐ1È˻ظ´
Postdoctoral position in theoretical physics/biophysics (France)
ÒѾÓÐ0È˻ظ´
Postdoctoral position the Goethe-University of Frankfurt
ÒѾÓÐ3È˻ظ´
postdoctoral position in theoretical chemistry
ÒѾÓÐ2È˻ظ´
Postdoctoral Research Position at University of Washington in Seattle
ÒѾÓÐ6È˻ظ´
Post-PhD position of university of Cambridge
ÒѾÓÐ6È˻ظ´
Postdoctoral position in astroparticle physics at the University of Zurich
ÒѾÓÐ0È˻ظ´
POSTDOCTORAL POSITION, National Taiwan University
ÒѾÓÐ9È˻ظ´
Thank you for your application for a position at the University of Canterbury
ÒѾÓÐ5È˻ظ´
Postdoctoral Position
ÒѾÓÐ8È˻ظ´
Postdoctoral position in California
ÒѾÓÐ1È˻ظ´
Postdoctoral Position at the University of British Columbia
ÒѾÓÐ2È˻ظ´
Postdoctoral Position at Colorado State University
ÒѾÓÐ2È˻ظ´
hupheng
Ìú¸Ëľ³æ (ÖøÃûдÊÖ)
- Ó¦Öú: 83 (³õÖÐÉú)
- ½ð±Ò: 5952.2
- É¢½ð: 1
- ºì»¨: 8
- Ìû×Ó: 1392
- ÔÚÏß: 293.3Сʱ
- ³æºÅ: 103353
- ×¢²á: 2005-11-14
- ÐÔ±ð: GG
- רҵ: ½ðÊôÓлú»¯Ñ§
7Â¥2014-09-25 02:37:12
hupheng
Ìú¸Ëľ³æ (ÖøÃûдÊÖ)
- Ó¦Öú: 83 (³õÖÐÉú)
- ½ð±Ò: 5952.2
- É¢½ð: 1
- ºì»¨: 8
- Ìû×Ó: 1392
- ÔÚÏß: 293.3Сʱ
- ³æºÅ: 103353
- ×¢²á: 2005-11-14
- ÐÔ±ð: GG
- רҵ: ½ðÊôÓлú»¯Ñ§
5Â¥2014-09-22 02:36:57
ldcsysu
ͳæ (СÓÐÃûÆø)
- Ó¦Öú: 0 (Ó×¶ùÔ°)
- ½ð±Ò: 109.2
- Ìû×Ó: 54
- ÔÚÏß: 90.5Сʱ
- ³æºÅ: 953221
- ×¢²á: 2010-02-06
- רҵ: ÓлúºÏ³É
6Â¥2014-09-22 21:40:55














»Ø¸´´ËÂ¥