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作者: Cui BC1, Yoon I2, Li JZ3, Lee WK4, Shim YK5. 文题: Synthesis and characterization of novel purpurinimides as photosensitizers for photodynamic therapy. 期刊名,年份,卷(期),起止页码: Int J Mol Sci. 2014 May 8;15(5):8091-105. doi: 10.3390/ijms15058091. 收录信息: 请帮忙查sci收录号是否已出！ |
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Synthesis and Characterization of Novel Purpurinimides as Photosensitizers for Photodynamic Therapy 作者:Cui, BC (Cui, Bing Cun)[ 1,2 ] ; Yoon, I (Yoon, Il)[ 2 ] ; Li, JZ (Li, Jia Zhu)[ 2,3 ] ; Lee, WK (Lee, Woo Kyoung)[ 2 ] ; Shim, YK (Shim, Young Key)[ 2 ] INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 卷: 15 期: 5 页: 8091-8105 DOI: 10.3390/ijms15058091 出版年: MAY 2014 查看期刊信息 摘要 A series of novel purpurinimides with long wavelength absorption were designed and synthesized to develop novel and potential photosensitizers. These compounds were investigated through reduction, oxidation, rearrangement reaction and amidation reactions of methyl pheophorbide a. They demonstrated a considerable bathochromic shift of the major absorption band in the red region of the optical spectrum (695-704 nm). Newly synthesized purpurinimides were screened for their antitumor activities, and showed higher photodynamic efficiency against A549 cell lines as compared to purpurin-18 methyl ester. The results revealed the novel purpurinimides could be potential photosensitizers. 关键词 作者关键词:purpurinimide; methyl pheophorbide a; photosensitizer; photodynamic therapy; singlet oxygen photogeneration; hydrophobicity parameter KeyWords Plus:EFFICIENT SYNTHESIS; SINGLET OXYGEN; DERIVATIVES; SERIES; TUMOR 作者信息 通讯作者地址: Yoon, I (通讯作者) 显示增强组织信息的名称 Inje Univ, Sch Nano Syst Engn, Photodynam Therapy PDT Res Inst, Gimhae 621749, South Korea. 地址: [ 1 ] Hubei Polytech Univ, Coll Med, Huangshi 435003, Peoples R China 显示增强组织信息的名称 [ 2 ] Inje Univ, Sch Nano Syst Engn, Photodynam Therapy PDT Res Inst, Gimhae 621749, South Korea 显示增强组织信息的名称 [ 3 ] Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China 电子邮件地址:cuibc928@hotmail.com; yoonil71@inje.ac.kr; jiazhu82@163.com; wlee@inje.ac.kr; ykshim@inje.ac.kr 基金资助致谢 基金资助机构 授权号 BK21 PLUS Project National Research Foundation (NRF) of Korea - Ministry of Education, Science and Technology NRF-2011-0007082 Hubei Key Discipline of Pharmacy Hubei Key Laboratory of the Renal Diseases Occurrence and Intervention 查看基金资助信息 出版商 MDPI AG, POSTFACH, CH-4005 BASEL, SWITZERLAND 类别 / 分类 研究方向:Chemistry Web of Science 类别:Chemistry, Multidisciplinary 文献信息 文献类型:Article 语种:English 入藏号: WOS:000336841800061 ISSN: 1422-0067 其他信息 IDS 号: AI4NJ Web of Science 核心合集中的 "引用的参考文献": 17 Web of Science 核心合集中的 "被引频次": 0 |
2楼2014-07-07 20:24:14