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【答案】应助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
感谢参与，应助指数 +1
bonny928: 金币+20, ★★★★★最佳答案, thanks 2014-07-07 21:47:22
sunshan4379: 检索EPI+1, 感谢应助！ 2014-07-08 10:45:16
Synthesis and Characterization of Novel Purpurinimides as Photosensitizers for Photodynamic Therapy
作者:Cui, BC (Cui, Bing Cun)[ 1,2 ] ; Yoon, I (Yoon, Il)[ 2 ] ; Li, JZ (Li, Jia Zhu)[ 2,3 ] ; Lee, WK (Lee, Woo Kyoung)[ 2 ] ; Shim, YK (Shim, Young Key)[ 2 ]
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷: 15 期: 5 页: 8091-8105
DOI: 10.3390/ijms15058091
出版年: MAY 2014
查看期刊信息
摘要
A series of novel purpurinimides with long wavelength absorption were designed and synthesized to develop novel and potential photosensitizers. These compounds were investigated through reduction, oxidation, rearrangement reaction and amidation reactions of methyl pheophorbide a. They demonstrated a considerable bathochromic shift of the major absorption band in the red region of the optical spectrum (695-704 nm). Newly synthesized purpurinimides were screened for their antitumor activities, and showed higher photodynamic efficiency against A549 cell lines as compared to purpurin-18 methyl ester. The results revealed the novel purpurinimides could be potential photosensitizers.
关键词
作者关键词:purpurinimide; methyl pheophorbide a; photosensitizer; photodynamic therapy; singlet oxygen photogeneration; hydrophobicity parameter
KeyWords Plus:EFFICIENT SYNTHESIS; SINGLET OXYGEN; DERIVATIVES; SERIES; TUMOR
作者信息
通讯作者地址: Yoon, I (通讯作者)
显示增强组织信息的名称 Inje Univ, Sch Nano Syst Engn, Photodynam Therapy PDT Res Inst, Gimhae 621749, South Korea.
地址:
[ 1 ] Hubei Polytech Univ, Coll Med, Huangshi 435003, Peoples R China
显示增强组织信息的名称 [ 2 ] Inje Univ, Sch Nano Syst Engn, Photodynam Therapy PDT Res Inst, Gimhae 621749, South Korea
显示增强组织信息的名称 [ 3 ] Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China
电子邮件地址:cuibc928@hotmail.com; yoonil71@inje.ac.kr; jiazhu82@163.com; wlee@inje.ac.kr; ykshim@inje.ac.kr
基金资助致谢
基金资助机构 授权号
BK21 PLUS Project
National Research Foundation (NRF) of Korea - Ministry of Education, Science and Technology
NRF-2011-0007082
Hubei Key Discipline of Pharmacy
Hubei Key Laboratory of the Renal Diseases Occurrence and Intervention
查看基金资助信息
出版商
MDPI AG, POSTFACH, CH-4005 BASEL, SWITZERLAND
类别 / 分类
研究方向:Chemistry
Web of Science 类别:Chemistry, Multidisciplinary
文献信息
文献类型:Article
语种:English
入藏号: WOS:000336841800061
ISSN: 1422-0067
其他信息
IDS 号: AI4NJ
Web of Science 核心合集中的 "引用的参考文献": 17
Web of Science 核心合集中的 "被引频次": 0 |
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