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shiranjiang
½ð³æ (ÕýʽдÊÖ)
- ·ÒëEPI: 14
- Ó¦Öú: 12 (СѧÉú)
- ½ð±Ò: 2856.9
- É¢½ð: 50
- ºì»¨: 6
- Ìû×Ó: 686
- ÔÚÏß: 86.6Сʱ
- ³æºÅ: 3041741
- ×¢²á: 2014-03-12
- ÐÔ±ð: MM
- רҵ: ½ðÊô½á¹¹²ÄÁÏ
¡¾´ð°¸¡¿Ó¦Öú»ØÌû
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ÕÔ¾ýºì: ½ð±Ò+25, ·ÒëEPI+1 2014-06-16 18:10:21
ÕÔ¾ýºì: ½ð±Ò+25, ·ÒëEPI+1 2014-06-16 18:10:21
| A was used to be the raw material,ethyl alcohol was used as the solvent in this experiment,under the condition of 80 ¡æ, substitution and reduction reaction occured to generate B when adding sodium hydrosulfite and sodium hydrosulphide.Then,ring-formation reaction took place with methyl alcohol at 70 ¡æ and C was generated.Substitution reaction occured under the condition of 120 ¡æ to generate D by the product generated last step and iodobenzene when taking CsCO3, CuI, Pd (Pph3) 4 as the catalyst,DMF as the solvent.Then oxidation reaction took place with MCPBA and the product dissolved by dichloromethane at room temperature,activating the pyridine ring, finally backflow happened by using activation product and phosphorus oxychloride at 115 ¡æ,replacing the pyridine ring four and the end-product E was generated. |
2Â¥2014-06-16 15:51:31
zhesmaj
½ð³æ (СÓÐÃûÆø)
- ·ÒëEPI: 6
- Ó¦Öú: 5 (Ó×¶ùÔ°)
- ½ð±Ò: 500.9
- É¢½ð: 50
- ºì»¨: 1
- Ìû×Ó: 115
- ÔÚÏß: 128.1Сʱ
- ³æºÅ: 1495955
- ×¢²á: 2011-11-17
- ÐÔ±ð: GG
- רҵ: Ò©¼Áѧ
¡¾´ð°¸¡¿Ó¦Öú»ØÌû
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ÕÔ¾ýºì: ½ð±Ò+25 2014-06-16 18:10:26
ÕÔ¾ýºì: ½ð±Ò+25 2014-06-16 18:10:26
| this experiment involves reacting A with hydrosulfite and sodium hydrosulfide in the presence of ethanol solution at 80¡æ£¬B is prepared though a substitution and reduction reaction. then C is obtained through a process of cyclization by B and methanol. the newly formed product is further reacting with iodobenzene at 120¡æ by a substitution reaction to give D. to obtain an activation of pyridine ring, D is dissolved in dichloromethane and further occurring an oxidation reaction with MCPBA. the final activation production is fluxed with phosphorus oxychloride at 115¡æ and undergoing a substitution reaction at the 4-position of pyridine to give the final product E. |

3Â¥2014-06-16 16:50:17














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