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[求助]
本科论文，关于合成，只翻译一段摘要，求虫友帮忙，感谢
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| 本实验以A为原料，乙醇为溶剂，80℃条件下，加保险粉、硫氢化钠发生取代和还原反应，生成B。然后在70℃与甲醇发生关环反应，生成C。以CsCO3、CuI、Pd(Pph3)4、为催化剂，DMF为溶剂将上步产物与碘苯在120℃条件下发生取代反应，生成D。然后用二氯甲烷溶解产物，在室温条件与MCPBA发生氧化反应，活化吡啶环，最后将活化产物在115℃与三氯氧磷回流，对吡啶环四位进行取代，生成终产物E。 |
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shiranjiang
金虫 (正式写手)
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赵君红: 金币+25, 翻译EPI+1 2014-06-16 18:10:21
赵君红: 金币+25, 翻译EPI+1 2014-06-16 18:10:21
| A was used to be the raw material,ethyl alcohol was used as the solvent in this experiment,under the condition of 80 ℃, substitution and reduction reaction occured to generate B when adding sodium hydrosulfite and sodium hydrosulphide.Then,ring-formation reaction took place with methyl alcohol at 70 ℃ and C was generated.Substitution reaction occured under the condition of 120 ℃ to generate D by the product generated last step and iodobenzene when taking CsCO3, CuI, Pd (Pph3) 4 as the catalyst,DMF as the solvent.Then oxidation reaction took place with MCPBA and the product dissolved by dichloromethane at room temperature,activating the pyridine ring, finally backflow happened by using activation product and phosphorus oxychloride at 115 ℃,replacing the pyridine ring four and the end-product E was generated. |
2楼2014-06-16 15:51:31
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赵君红: 金币+25 2014-06-16 18:10:26
赵君红: 金币+25 2014-06-16 18:10:26
| this experiment involves reacting A with hydrosulfite and sodium hydrosulfide in the presence of ethanol solution at 80℃，B is prepared though a substitution and reduction reaction. then C is obtained through a process of cyclization by B and methanol. the newly formed product is further reacting with iodobenzene at 120℃ by a substitution reaction to give D. to obtain an activation of pyridine ring, D is dissolved in dichloromethane and further occurring an oxidation reaction with MCPBA. the final activation production is fluxed with phosphorus oxychloride at 115℃ and undergoing a substitution reaction at the 4-position of pyridine to give the final product E. |
3楼2014-06-16 16:50:17
