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2008guoym: 金币+5 2014-06-07 20:01:11
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Accession number:
20133116552465
Title: Nanomaterials for ultrasensitive protein detection
Authors: Zhang, Yi1, 2; Guo, Yongming1, 3; Xianyu, Yunlei1; Chen, Wenwen1; Zhao, Yuyun1; Jiang, Xingyu1
Author affiliation: 1 CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China
2 Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China
3 Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, China
Corresponding author: Jiang, X. (xingyujiang@nanoctr.cn)
Source title: Advanced Materials
Abbreviated source title: Adv Mater
Volume: 25
Issue: 28
Monograph title: 10th Anniversary of the National Center for Nanoscience and Technology of China
Issue date: July 26, 2013
Publication year: 2013
Pages: 3802-3819
Language: English
ISSN: 09359648
E-ISSN: 15214095
CODEN: ADVMEW
Document type: Journal article (JA)
Publisher: Wiley-VCH Verlag, Buhringstrasse 10, Berlin, D-13086, Germany
Abstract: The advances of nanomaterials have provided exciting technologies and novel materials for protein detection, based on the unique properties associated with nanoscale phenomena such as plasmon resonance, catalysis and energy transfer. This article reviews a series of nanomaterials including nanoparticles, nanofibers, nanowires, and nanosheets, and evaluates their performances in the application for protein detection, focusing on approaches that realize ultrasensitive detection. Many of these nanomaterials were used to analyze clinically relevant protein biomarkers. Their detection in the picomolar, femtomolar or even zeptomolar regime has been realized, sometimes even with naked-eye readout. We summarize the detection methods and results according to materials and targets, review the current challenges, and discuss the solution in the context of technological integration such as combining nanomaterials with microfluidics, and classical analytical technologies. Nanomaterials provide exciting tools for ultrasensitive detection of proteins. Detection of clinically relevant protein biomarkers down to the zeptomolar regime is possible. These methods could be integrated with microfluidics and other analytical technologies to assay important proteins in complex biological samples. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Number of references: 182
Main heading: Nanostructured materials
Controlled terms: Chemical detection - Energy transfer - Error detection - Microfluidics - Nanotechnology - Nanowires - Proteins - Technology
Uncontrolled terms: Analytical technology - Biological samples - Detection methods - Nanomaterial - Nanoscale phenomenon - Plasmon resonances - sensitivity - Ultrasensitive detection
Classification code: 901 Engineering Profession - 804.1 Organic Compounds - 801 Chemistry - 933 Solid State Physics - 761 Nanotechnology - 641.2 Heat Transfer - 631 Fluid Flow - 721.1 Computer Theory, Includes Formal Logic, Automata Theory, Switching Theory, Programming Theory
DOI: 10.1002/adma.201301334
Database: Compendex
Compilation and indexing terms, © 2013 Elsevier Inc. |
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