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流光逸影
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2008guoym: 金币+5 2014-06-07 20:01:11
oven1986: 检索EPI+1, 感谢应助！ 2014-06-07 23:40:43
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Accession number: 20133116552465 Title: Nanomaterials for ultrasensitive protein detection Authors: Zhang, Yi1, 2; Guo, Yongming1, 3; Xianyu, Yunlei1; Chen, Wenwen1; Zhao, Yuyun1; Jiang, Xingyu1 Author affiliation: 1 CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China 2 Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China 3 Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, China Corresponding author: Jiang, X. (xingyujiang@nanoctr.cn) Source title: Advanced Materials Abbreviated source title: Adv Mater Volume: 25 Issue: 28 Monograph title: 10th Anniversary of the National Center for Nanoscience and Technology of China Issue date: July 26, 2013 Publication year: 2013 Pages: 3802-3819 Language: English ISSN: 09359648 E-ISSN: 15214095 CODEN: ADVMEW Document type: Journal article (JA) Publisher: Wiley-VCH Verlag, Buhringstrasse 10, Berlin, D-13086, Germany Abstract: The advances of nanomaterials have provided exciting technologies and novel materials for protein detection, based on the unique properties associated with nanoscale phenomena such as plasmon resonance, catalysis and energy transfer. This article reviews a series of nanomaterials including nanoparticles, nanofibers, nanowires, and nanosheets, and evaluates their performances in the application for protein detection, focusing on approaches that realize ultrasensitive detection. Many of these nanomaterials were used to analyze clinically relevant protein biomarkers. Their detection in the picomolar, femtomolar or even zeptomolar regime has been realized, sometimes even with naked-eye readout. We summarize the detection methods and results according to materials and targets, review the current challenges, and discuss the solution in the context of technological integration such as combining nanomaterials with microfluidics, and classical analytical technologies. Nanomaterials provide exciting tools for ultrasensitive detection of proteins. Detection of clinically relevant protein biomarkers down to the zeptomolar regime is possible. These methods could be integrated with microfluidics and other analytical technologies to assay important proteins in complex biological samples. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Number of references: 182 Main heading: Nanostructured materials Controlled terms: Chemical detection - Energy transfer - Error detection - Microfluidics - Nanotechnology - Nanowires - Proteins - Technology Uncontrolled terms: Analytical technology - Biological samples - Detection methods - Nanomaterial - Nanoscale phenomenon - Plasmon resonances - sensitivity - Ultrasensitive detection Classification code: 901 Engineering Profession - 804.1 Organic Compounds - 801 Chemistry - 933 Solid State Physics - 761 Nanotechnology - 641.2 Heat Transfer - 631 Fluid Flow - 721.1 Computer Theory, Includes Formal Logic, Automata Theory, Switching Theory, Programming Theory DOI: 10.1002/adma.201301334 Database: Compendex Compilation and indexing terms, © 2013 Elsevier Inc. |
2楼2014-06-07 19:48:16
流光逸影
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3楼2014-06-07 19:48:41
流光逸影
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believe in yourself
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4楼2014-06-07 19:51:05
