查看: 1724  |  回复: 0

lijun585429

铜虫 (初入文坛)

[求助] 文章投稿后一个月,收到编辑的大修意见

第一次投英文文章,投稿后一个月收到编辑的回复了,建议大修。一共找了两个审稿人,第一个意见比较尖锐不建议接收;第二个比较nice一些,提了6个问题,但是都是比较positive的,一些建议什么的。 另附上reviewer1的意见大家帮忙分析一下该如何回复,非常感谢了。

Reviewer #1: General comments

This study investigated “文章标题...." 。As the results, hPDLCs conditioned by” 一种物质“ demonstrated a significant increase in proliferation and also showed an increased formation of mineralized matrix nodules and increased ALP activity with the attendant expression of Runx2. Based on these findings, the authors suggested that ”一种物质“ induces proliferation and osteogenic differentiation of hPDLCs, indicating that”一种物质“ may be applicable as a novel autologous graft in periodontal tissue engineering regeneration. The aims of this study are clear and the results obtained are interesting. However, the current findings appeared to quite preliminary data. Without the data showing the possible mechanisms by which”一种物质“ stimulated proliferation and osteoblast differentiation of hPDLCs, it can't be further considerable for acceptance.

Specific comments
First of all, there was no a study to verify the mechanisms involved in the ”一种物质“-mediated increases in proliferation and differentiation of the cells. It is strongly recommended to show why the blood samples did so in the hPDLCs. Especially, to end this, the authors have to try to check cell cycle progression using flow cytometer and then to analyze what are the regulatory factors such as CDKs and/or cyclins are involved therein by Western blot analysis. In addition, the authors showed the expression pattern of Runx2 as an osteogenic marker. Of course, this factor might be one of the most important osteogenic factors. However, it will be needed to show that which of the signaling molecules are closely associated with the induction of Runx2 as a second messenger by treating the cells with the blood samples. With these additional experiments, the authors are also capable of explaining the reason why the ”一种物质“ among the samples showed the most prominent activities.

Minor comments
1.        The figures 2 and 3 are not necessary in this manuscript, rather it is recommended to show as a supplemental figure.
2.        Please check carefully misspelling (ex, HPDLCs -> hPDLCs) and grammatical errors.
3.        The length of several sentences shown in the highlights appeared to be over a general limitation. Please check this with consideration of the Journal Policy.

总结起来,这位reviewer的意见就是集中在该文章未做机制方面的研究。事实上我也确实没有再对此深入下去,这方面的文章很少做到机制层面上的,因为该物质成分比较复杂,硕士期间也没能力在这方面深入下去,不过我以后倒是有这方面的想法。我也知道自己文章比较浅显所以才投的这个杂志(IF=1.5),如果做到机制方面的话,肯定会投3分以上的文章了。  现在不知道如何回复这个reviewer,编辑给我修回的时间是4周。
回复此楼
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

智能机器人

Robot (super robot)

我们都爱小木虫

找到一些相关的精华帖子,希望有用哦~

科研从小木虫开始,人人为我,我为人人
相关版块跳转 我要订阅楼主 lijun585429 的主题更新
最具人气热帖推荐 [查看全部] 作者 回/看 最后发表
[硕博家园] 难道我真的要放弃吗? +7 133456 2024-06-20 7/350 2024-06-21 01:29 by 飘过的晚辈
[基金申请] 江苏省333人才工程 出校后被刷的概率大不大? +4 maxbirdzhang 2024-06-19 4/200 2024-06-20 22:38 by sunss
[基金申请] 工材口青年基金上会可能性 +9 今晚推荐22 2024-06-19 11/550 2024-06-20 22:30 by andywei1028
[基金申请] 工材口青年基金大概什么样能上会? +12 今晚推荐22 2024-06-20 17/850 2024-06-20 21:50 by 今晚推荐22
[博后之家] 在国内某高校做全职博士后2年,现在找到新的单位,出站或退站对新工作有什么影响? +3 nxplfcc 2024-06-20 3/150 2024-06-20 19:50 by zhangysbad
[基金申请] 青年基金会评专家到底是怎么会评的呀?主审专家是不是一般不会改动系统按函评给的顺序 5+4 他山攻玉之石 2024-06-18 18/900 2024-06-20 16:33 by 他山攻玉之石
[论文投稿] 投稿求助 +4 平凡的日子 2024-06-19 5/250 2024-06-20 16:24 by yueyueyue@
[有机交流] 怎么萃取出锡盐内包裹的化合物 +3 硕六过 2024-06-19 4/200 2024-06-20 15:45 by 2461777831
[考博] 2025年博士申请,可先做科研助理 +4 limit888 2024-06-18 7/350 2024-06-20 10:23 by 安塔瓦拉多
[论文投稿] Scientific Reports二审90天了,催稿也没反应怎么办? +3 智晨君 2024-06-18 6/300 2024-06-19 20:08 by licheng78
[基金申请] F口信息学部拿面上,大概需要什么样的成果 +7 _奋黎_ 2024-06-16 18/900 2024-06-19 20:02 by _奋黎_
[基金申请] 面上博士后 +3 jsqy 2024-06-19 3/150 2024-06-19 17:58 by bxwisdom_886
[基金申请] Nature 11日发文,中国著名学者们称造假迫不得已 +8 babu2015 2024-06-14 8/400 2024-06-19 15:25 by 风今25
[公派出国] 去英国的小伙伴儿都在哪儿租的房子呀? +7 65syn 2024-06-14 11/550 2024-06-19 10:19 by 65syn
[基金申请] 博后基金刷到的BUG,图片来的更直观 +15 carolloo 2024-06-17 16/800 2024-06-19 09:42 by msjy
[公派出国] CSC德国博后每个月资助多少呀?够用吗 +4 326lhpqk 2024-06-16 7/350 2024-06-19 02:03 by PLHOU
[论文投稿] 投稿求助 10+3 2022_灵魂工程师 2024-06-16 8/400 2024-06-18 12:12 by 投必得科研顾问
[高分子] 烧瓶内合成聚酯 +3 大帝国乐 2024-06-17 7/350 2024-06-18 11:10 by 大帝国乐
[基金申请] 博士后创新人才支持计划公示 +9 aishida144 2024-06-14 15/750 2024-06-16 09:52 by msjy
[基金申请] 关于博后基金的bug问题 +6 lxr1991 2024-06-14 9/450 2024-06-15 21:17 by since—2010
信息提示
请填处理意见